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Gene: CTCF |
Gene summary for CTCF |
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Gene information | Species | Human | Gene symbol | CTCF | Gene ID | 10664 |
Gene name | CCCTC-binding factor | |
Gene Alias | CFAP108 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P49711 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10664 | CTCF | LZE4T | Human | Esophagus | ESCC | 4.74e-14 | 4.00e-01 | 0.0811 |
10664 | CTCF | LZE7T | Human | Esophagus | ESCC | 2.56e-03 | 2.35e-01 | 0.0667 |
10664 | CTCF | LZE22T | Human | Esophagus | ESCC | 7.69e-04 | 2.31e-01 | 0.068 |
10664 | CTCF | LZE24T | Human | Esophagus | ESCC | 8.12e-15 | 3.66e-01 | 0.0596 |
10664 | CTCF | P1T-E | Human | Esophagus | ESCC | 1.17e-13 | 5.93e-01 | 0.0875 |
10664 | CTCF | P2T-E | Human | Esophagus | ESCC | 2.92e-50 | 9.19e-01 | 0.1177 |
10664 | CTCF | P4T-E | Human | Esophagus | ESCC | 5.21e-28 | 6.83e-01 | 0.1323 |
10664 | CTCF | P5T-E | Human | Esophagus | ESCC | 1.72e-28 | 4.61e-01 | 0.1327 |
10664 | CTCF | P8T-E | Human | Esophagus | ESCC | 2.34e-27 | 4.43e-01 | 0.0889 |
10664 | CTCF | P9T-E | Human | Esophagus | ESCC | 3.35e-11 | 3.13e-01 | 0.1131 |
10664 | CTCF | P10T-E | Human | Esophagus | ESCC | 1.96e-21 | 4.87e-01 | 0.116 |
10664 | CTCF | P11T-E | Human | Esophagus | ESCC | 1.56e-08 | 4.65e-01 | 0.1426 |
10664 | CTCF | P12T-E | Human | Esophagus | ESCC | 2.33e-19 | 3.47e-01 | 0.1122 |
10664 | CTCF | P15T-E | Human | Esophagus | ESCC | 5.76e-22 | 4.50e-01 | 0.1149 |
10664 | CTCF | P16T-E | Human | Esophagus | ESCC | 5.51e-19 | 2.67e-01 | 0.1153 |
10664 | CTCF | P17T-E | Human | Esophagus | ESCC | 5.42e-04 | 2.05e-01 | 0.1278 |
10664 | CTCF | P20T-E | Human | Esophagus | ESCC | 1.71e-11 | 2.64e-01 | 0.1124 |
10664 | CTCF | P21T-E | Human | Esophagus | ESCC | 6.16e-18 | 2.66e-01 | 0.1617 |
10664 | CTCF | P22T-E | Human | Esophagus | ESCC | 1.14e-19 | 3.99e-01 | 0.1236 |
10664 | CTCF | P23T-E | Human | Esophagus | ESCC | 2.07e-22 | 5.60e-01 | 0.108 |
Page: 1 2 3 4 5 6 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:003304416 | Esophagus | ESCC | regulation of chromosome organization | 145/8552 | 187/18723 | 3.80e-19 | 4.31e-17 | 145 |
GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
GO:001839413 | Esophagus | ESCC | peptidyl-lysine acetylation | 123/8552 | 169/18723 | 6.58e-13 | 2.94e-11 | 123 |
GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
GO:004354313 | Esophagus | ESCC | protein acylation | 165/8552 | 243/18723 | 1.69e-12 | 7.14e-11 | 165 |
GO:000647313 | Esophagus | ESCC | protein acetylation | 140/8552 | 201/18723 | 4.37e-12 | 1.69e-10 | 140 |
GO:001839313 | Esophagus | ESCC | internal peptidyl-lysine acetylation | 114/8552 | 158/18723 | 1.16e-11 | 4.24e-10 | 114 |
GO:000647513 | Esophagus | ESCC | internal protein amino acid acetylation | 115/8552 | 160/18723 | 1.43e-11 | 5.08e-10 | 115 |
GO:00165735 | Esophagus | ESCC | histone acetylation | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:003105614 | Esophagus | ESCC | regulation of histone modification | 106/8552 | 152/18723 | 1.52e-09 | 3.55e-08 | 106 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:003450211 | Esophagus | ESCC | protein localization to chromosome | 70/8552 | 92/18723 | 2.54e-09 | 5.64e-08 | 70 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00400295 | Esophagus | ESCC | regulation of gene expression, epigenetic | 74/8552 | 105/18723 | 2.24e-07 | 3.42e-06 | 74 |
GO:000647914 | Esophagus | ESCC | protein methylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:000821314 | Esophagus | ESCC | protein alkylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTCF | insertion | Frame_Shift_Ins | novel | c.506_507insG | p.Ala171GlyfsTer20 | p.A171Gfs*20 | P49711 | protein_coding | TCGA-BA-5151-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
CTCF | insertion | Frame_Shift_Ins | novel | c.603_604insA | p.Thr204AsnfsTer26 | p.T204Nfs*26 | P49711 | protein_coding | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CTCF | deletion | Frame_Shift_Del | novel | c.1754_1766delGGGAAAATGGAGG | p.Gly585GlufsTer42 | p.G585Efs*42 | P49711 | protein_coding | TCGA-H7-7774-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
CTCF | insertion | Frame_Shift_Ins | novel | c.603_604insA | p.Thr204AsnfsTer26 | p.T204Nfs*26 | P49711 | protein_coding | TCGA-UF-A7JD-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
CTCF | SNV | Missense_Mutation | c.1103N>A | p.Arg368His | p.R368H | P49711 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-SU-A7E7-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Unknown | Unknown | SD | |
CTCF | SNV | Missense_Mutation | novel | c.679N>C | p.Asp227His | p.D227H | P49711 | protein_coding | tolerated(0.06) | probably_damaging(0.997) | TCGA-V1-A8MU-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Hormone Therapy | lhrh | SD |
CTCF | SNV | Missense_Mutation | novel | c.1577G>A | p.Ser526Asn | p.S526N | P49711 | protein_coding | tolerated(0.52) | possibly_damaging(0.75) | TCGA-XK-AAJ3-01 | Prostate | prostate adenocarcinoma | Male | <65 | 8 | Unknown | Unknown | SD |
CTCF | SNV | Missense_Mutation | c.1181T>C | p.Leu394Pro | p.L394P | P49711 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8588-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CTCF | SNV | Missense_Mutation | c.1016N>A | p.Arg339Gln | p.R339Q | P49711 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BR-8592-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | etoposide | CR | |
CTCF | SNV | Missense_Mutation | c.838A>C | p.Asn280His | p.N280H | P49711 | protein_coding | tolerated(0.1) | probably_damaging(0.997) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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