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Gene: ZMYM4 |
Gene summary for ZMYM4 |
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Gene information | Species | Human | Gene symbol | ZMYM4 | Gene ID | 9202 |
Gene name | zinc finger MYM-type containing 4 | |
Gene Alias | CDIR | |
Cytomap | 1p34.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q5VZL5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9202 | ZMYM4 | CCI_3 | Human | Cervix | CC | 9.19e-04 | 6.33e-01 | 0.516 |
9202 | ZMYM4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.47e-14 | -5.60e-01 | 0.0155 |
9202 | ZMYM4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.38e-06 | -5.22e-01 | -0.1808 |
9202 | ZMYM4 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.66e-04 | -5.03e-01 | -0.1526 |
9202 | ZMYM4 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.32e-04 | -4.01e-01 | -0.1464 |
9202 | ZMYM4 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.43e-07 | -3.66e-01 | -0.1001 |
9202 | ZMYM4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.17e-02 | -6.69e-01 | -0.2061 |
9202 | ZMYM4 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.89e-04 | -5.92e-01 | -0.0179 |
9202 | ZMYM4 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.22e-06 | -4.23e-01 | 0.096 |
9202 | ZMYM4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.05e-09 | -4.11e-01 | 0.0674 |
9202 | ZMYM4 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.25e-03 | -3.14e-01 | 0.0588 |
9202 | ZMYM4 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.48e-02 | -2.89e-01 | 0.3859 |
9202 | ZMYM4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.63e-18 | -5.62e-01 | 0.3005 |
9202 | ZMYM4 | A015-C-203 | Human | Colorectum | FAP | 7.85e-24 | -2.58e-01 | -0.1294 |
9202 | ZMYM4 | A015-C-204 | Human | Colorectum | FAP | 2.00e-04 | -1.99e-01 | -0.0228 |
9202 | ZMYM4 | A014-C-040 | Human | Colorectum | FAP | 2.66e-02 | -2.64e-01 | -0.1184 |
9202 | ZMYM4 | A002-C-201 | Human | Colorectum | FAP | 3.44e-11 | -2.63e-01 | 0.0324 |
9202 | ZMYM4 | A002-C-203 | Human | Colorectum | FAP | 2.75e-02 | -5.18e-02 | 0.2786 |
9202 | ZMYM4 | A001-C-119 | Human | Colorectum | FAP | 9.36e-05 | -4.06e-01 | -0.1557 |
9202 | ZMYM4 | A001-C-108 | Human | Colorectum | FAP | 2.16e-13 | -9.41e-02 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:00226041 | Colorectum | SER | regulation of cell morphogenesis | 89/2897 | 309/18723 | 1.51e-09 | 1.52e-07 | 89 |
GO:00226042 | Colorectum | MSS | regulation of cell morphogenesis | 103/3467 | 309/18723 | 2.70e-10 | 2.56e-08 | 103 |
GO:00226044 | Colorectum | FAP | regulation of cell morphogenesis | 87/2622 | 309/18723 | 4.89e-11 | 1.87e-08 | 87 |
GO:00226045 | Colorectum | CRC | regulation of cell morphogenesis | 74/2078 | 309/18723 | 9.25e-11 | 5.04e-08 | 74 |
GO:002260415 | Endometrium | AEH | regulation of cell morphogenesis | 79/2100 | 309/18723 | 1.04e-12 | 2.24e-10 | 79 |
GO:002260416 | Endometrium | EEC | regulation of cell morphogenesis | 78/2168 | 309/18723 | 1.45e-11 | 2.28e-09 | 78 |
GO:002260420 | Esophagus | ESCC | regulation of cell morphogenesis | 180/8552 | 309/18723 | 5.19e-06 | 5.45e-05 | 180 |
GO:00226047 | Liver | NAFLD | regulation of cell morphogenesis | 62/1882 | 309/18723 | 8.35e-08 | 7.09e-06 | 62 |
GO:002260412 | Liver | Cirrhotic | regulation of cell morphogenesis | 127/4634 | 309/18723 | 1.45e-10 | 7.44e-09 | 127 |
GO:002260422 | Liver | HCC | regulation of cell morphogenesis | 188/7958 | 309/18723 | 4.84e-11 | 1.82e-09 | 188 |
GO:00226048 | Lung | IAC | regulation of cell morphogenesis | 74/2061 | 309/18723 | 6.31e-11 | 1.70e-08 | 74 |
GO:002260413 | Lung | AIS | regulation of cell morphogenesis | 65/1849 | 309/18723 | 2.97e-09 | 5.09e-07 | 65 |
GO:002260423 | Lung | AAH | regulation of cell morphogenesis | 30/613 | 309/18723 | 1.18e-07 | 6.77e-05 | 30 |
GO:002260432 | Lung | MIAC | regulation of cell morphogenesis | 38/967 | 309/18723 | 6.47e-07 | 9.76e-05 | 38 |
GO:002260417 | Prostate | BPH | regulation of cell morphogenesis | 99/3107 | 309/18723 | 1.30e-11 | 9.72e-10 | 99 |
GO:002260418 | Prostate | Tumor | regulation of cell morphogenesis | 102/3246 | 309/18723 | 1.25e-11 | 9.49e-10 | 102 |
GO:002260426 | Skin | AK | regulation of cell morphogenesis | 66/1910 | 309/18723 | 4.34e-09 | 3.30e-07 | 66 |
GO:0022604111 | Skin | SCCIS | regulation of cell morphogenesis | 36/919 | 309/18723 | 1.41e-06 | 8.79e-05 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZMYM4 | insertion | Frame_Shift_Ins | novel | c.1032_1033insA | p.Ile347AsnfsTer62 | p.I347Nfs*62 | Q5VZL5 | protein_coding | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | ||
ZMYM4 | deletion | Frame_Shift_Del | rs755663477 | c.1282delN | p.Lys430AsnfsTer6 | p.K430Nfs*6 | Q5VZL5 | protein_coding | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
ZMYM4 | deletion | Frame_Shift_Del | c.1033delN | p.Ile347SerfsTer51 | p.I347Sfs*51 | Q5VZL5 | protein_coding | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |||
ZMYM4 | deletion | Frame_Shift_Del | c.1033delN | p.Ile347SerfsTer51 | p.I347Sfs*51 | Q5VZL5 | protein_coding | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
ZMYM4 | deletion | Frame_Shift_Del | rs755663477 | c.1282delN | p.Lys430AsnfsTer6 | p.K430Nfs*6 | Q5VZL5 | protein_coding | TCGA-D7-A4YY-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
ZMYM4 | deletion | Frame_Shift_Del | rs755663477 | c.1282delN | p.Lys430AsnfsTer6 | p.K430Nfs*6 | Q5VZL5 | protein_coding | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
ZMYM4 | deletion | Frame_Shift_Del | rs755663477 | c.1282delN | p.Lys430AsnfsTer6 | p.K430Nfs*6 | Q5VZL5 | protein_coding | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD | ||
ZMYM4 | deletion | Frame_Shift_Del | rs755663477 | c.1282delN | p.Lys430AsnfsTer6 | p.K430Nfs*6 | Q5VZL5 | protein_coding | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | ||
ZMYM4 | deletion | Frame_Shift_Del | novel | c.2633_2634delNN | p.Leu878GlnfsTer27 | p.L878Qfs*27 | Q5VZL5 | protein_coding | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | ||
ZMYM4 | SNV | Missense_Mutation | novel | c.2498G>T | p.Gly833Val | p.G833V | Q5VZL5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BJ-A191-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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