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Gene: TRPM8 |
Gene summary for TRPM8 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TRPM8 | Gene ID | 79054 |
| Gene name | transient receptor potential cation channel subfamily M member 8 | |
| Gene Alias | LTRPC6 | |
| Cytomap | 2q37.1 | |
| Gene Type | protein-coding | GO ID | GO:0001659 | UniProtAcc | Q7Z2W7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 79054 | TRPM8 | HCC1 | Human | Liver | HCC | 6.61e-04 | 1.90e+00 | 0.5336 |
| 79054 | TRPM8 | HCC2 | Human | Liver | HCC | 2.58e-04 | 6.72e-01 | 0.5341 |
| 79054 | TRPM8 | HCC5 | Human | Liver | HCC | 1.63e-03 | 1.64e+00 | 0.4932 |
| 79054 | TRPM8 | S027 | Human | Liver | HCC | 3.60e-14 | 7.39e-01 | 0.2446 |
| 79054 | TRPM8 | S028 | Human | Liver | HCC | 4.21e-05 | 3.30e-01 | 0.2503 |
| 79054 | TRPM8 | S029 | Human | Liver | HCC | 6.22e-06 | 3.56e-01 | 0.2581 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000926611 | Liver | HCC | response to temperature stimulus | 101/7958 | 178/18723 | 8.55e-05 | 7.48e-04 | 101 |
| GO:010610611 | Liver | HCC | cold-induced thermogenesis | 76/7958 | 144/18723 | 8.07e-03 | 3.18e-02 | 76 |
| GO:012016111 | Liver | HCC | regulation of cold-induced thermogenesis | 76/7958 | 144/18723 | 8.07e-03 | 3.18e-02 | 76 |
| GO:199084511 | Liver | HCC | adaptive thermogenesis | 81/7958 | 157/18723 | 1.32e-02 | 4.72e-02 | 81 |
| GO:000926615 | Prostate | Tumor | response to temperature stimulus | 59/3246 | 178/18723 | 2.14e-07 | 5.21e-06 | 59 |
| GO:00094099 | Prostate | Tumor | response to cold | 17/3246 | 49/18723 | 2.61e-03 | 1.43e-02 | 17 |
| GO:01201623 | Prostate | Tumor | positive regulation of cold-induced thermogenesis | 28/3246 | 97/18723 | 3.35e-03 | 1.74e-02 | 28 |
| GO:19908453 | Prostate | Tumor | adaptive thermogenesis | 41/3246 | 157/18723 | 3.63e-03 | 1.86e-02 | 41 |
| GO:00016593 | Prostate | Tumor | temperature homeostasis | 44/3246 | 174/18723 | 5.04e-03 | 2.45e-02 | 44 |
| GO:01061064 | Prostate | Tumor | cold-induced thermogenesis | 37/3246 | 144/18723 | 7.29e-03 | 3.25e-02 | 37 |
| GO:01201614 | Prostate | Tumor | regulation of cold-induced thermogenesis | 37/3246 | 144/18723 | 7.29e-03 | 3.25e-02 | 37 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TRPM8 | SNV | Missense_Mutation | rs200217624 | c.2206N>A | p.Val736Met | p.V736M | Q7Z2W7 | protein_coding | deleterious(0) | possibly_damaging(0.902) | TCGA-P3-A6T5-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| TRPM8 | SNV | Missense_Mutation | rs200565245 | c.304G>A | p.Ala102Thr | p.A102T | Q7Z2W7 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
| TRPM8 | SNV | Missense_Mutation | rs745586338 | c.787N>A | p.Val263Met | p.V263M | Q7Z2W7 | protein_coding | deleterious(0) | possibly_damaging(0.558) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
| TRPM8 | SNV | Missense_Mutation | rs202194673 | c.64C>T | p.Arg22Trp | p.R22W | Q7Z2W7 | protein_coding | deleterious(0) | benign(0.23) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| TRPM8 | SNV | Missense_Mutation | rs371608612 | c.1979N>T | p.Ala660Val | p.A660V | Q7Z2W7 | protein_coding | deleterious(0) | benign(0.181) | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TRPM8 | SNV | Missense_Mutation | novel | c.818T>G | p.Val273Gly | p.V273G | Q7Z2W7 | protein_coding | tolerated(0.09) | benign(0.001) | TCGA-KB-A93G-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| TRPM8 | SNV | Missense_Mutation | novel | c.59N>A | p.Ser20Asn | p.S20N | Q7Z2W7 | protein_coding | tolerated(0.13) | benign(0.242) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
| TRPM8 | SNV | Missense_Mutation | novel | c.1049N>G | p.Thr350Arg | p.T350R | Q7Z2W7 | protein_coding | deleterious(0.01) | benign(0.091) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
| TRPM8 | SNV | Missense_Mutation | rs200772894 | c.1454N>A | p.Arg485Gln | p.R485Q | Q7Z2W7 | protein_coding | tolerated(0.17) | benign(0) | TCGA-VQ-A8P8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TRPM8 | deletion | Frame_Shift_Del | rs774214043 | c.2295delN | p.Glu768SerfsTer16 | p.E768Sfs*16 | Q7Z2W7 | protein_coding | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | blocker | 135651503 | ||
| 79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | blocker | 135649885 | ||
| 79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | blocker | 178100954 | ||
| 79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | blocker | 178101078 | ||
| 79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | blocker | 135651438 | ANANDAMIDE | |
| 79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | activator | 135651519 | ||
| 79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | antagonist | 354702247 | ELISMETREP | |
| 79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | antagonist | 404859145 | ||
| 79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | D3263 | |||
| 79054 | TRPM8 | DRUGGABLE GENOME, ION CHANNEL, EXTERNAL SIDE OF PLASMA MEMBRANE | MENTHOL | MENTHOL | 17293875 |
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