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Gene: TOGARAM1 |
Gene summary for TOGARAM1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TOGARAM1 | Gene ID | 23116 |
Gene name | TOG array regulator of axonemal microtubules 1 | |
Gene Alias | FAM179B | |
Cytomap | 14q21.2 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | B4DHM7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23116 | TOGARAM1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.84e-12 | -5.60e-01 | 0.0155 |
23116 | TOGARAM1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.56e-04 | -5.17e-01 | -0.1808 |
23116 | TOGARAM1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.74e-05 | -5.22e-01 | -0.1088 |
23116 | TOGARAM1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.56e-02 | -3.82e-01 | -0.1954 |
23116 | TOGARAM1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.83e-06 | -6.02e-01 | -0.1207 |
23116 | TOGARAM1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.14e-12 | -4.62e-01 | -0.1464 |
23116 | TOGARAM1 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.46e-14 | -5.16e-01 | -0.1001 |
23116 | TOGARAM1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.59e-04 | -4.57e-01 | -0.059 |
23116 | TOGARAM1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.80e-05 | -6.52e-01 | -0.2061 |
23116 | TOGARAM1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.37e-06 | -4.92e-01 | 0.096 |
23116 | TOGARAM1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.45e-02 | -5.87e-01 | -0.0177 |
23116 | TOGARAM1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.52e-03 | -4.88e-01 | 0.0338 |
23116 | TOGARAM1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.32e-06 | -4.21e-01 | 0.0674 |
23116 | TOGARAM1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.32e-03 | -5.19e-01 | 0.0588 |
23116 | TOGARAM1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.40e-36 | -6.52e-01 | 0.294 |
23116 | TOGARAM1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.30e-11 | -6.52e-01 | 0.281 |
23116 | TOGARAM1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.39e-34 | -6.52e-01 | 0.3859 |
23116 | TOGARAM1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 9.55e-09 | -6.52e-01 | 0.2585 |
23116 | TOGARAM1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.96e-35 | -6.52e-01 | 0.3005 |
23116 | TOGARAM1 | A015-C-203 | Human | Colorectum | FAP | 8.91e-19 | -1.44e-01 | -0.1294 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:1902905 | Colorectum | AD | positive regulation of supramolecular fiber organization | 85/3918 | 209/18723 | 5.95e-11 | 6.33e-09 | 85 |
GO:0051495 | Colorectum | AD | positive regulation of cytoskeleton organization | 89/3918 | 226/18723 | 1.61e-10 | 1.56e-08 | 89 |
GO:0032273 | Colorectum | AD | positive regulation of protein polymerization | 62/3918 | 138/18723 | 1.94e-10 | 1.76e-08 | 62 |
GO:0031334 | Colorectum | AD | positive regulation of protein-containing complex assembly | 91/3918 | 237/18723 | 4.78e-10 | 3.99e-08 | 91 |
GO:0007051 | Colorectum | AD | spindle organization | 58/3918 | 184/18723 | 4.71e-04 | 5.20e-03 | 58 |
GO:1902850 | Colorectum | AD | microtubule cytoskeleton organization involved in mitosis | 48/3918 | 147/18723 | 5.87e-04 | 6.21e-03 | 48 |
GO:0090307 | Colorectum | AD | mitotic spindle assembly | 25/3918 | 65/18723 | 9.12e-04 | 8.71e-03 | 25 |
GO:0007052 | Colorectum | AD | mitotic spindle organization | 40/3918 | 120/18723 | 1.03e-03 | 9.61e-03 | 40 |
GO:0051225 | Colorectum | AD | spindle assembly | 37/3918 | 117/18723 | 4.32e-03 | 2.96e-02 | 37 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
GO:0070507 | Colorectum | AD | regulation of microtubule cytoskeleton organization | 44/3918 | 148/18723 | 7.05e-03 | 4.31e-02 | 44 |
GO:19029031 | Colorectum | SER | regulation of supramolecular fiber organization | 114/2897 | 383/18723 | 7.32e-13 | 1.95e-10 | 114 |
GO:00322711 | Colorectum | SER | regulation of protein polymerization | 78/2897 | 233/18723 | 5.71e-12 | 1.17e-09 | 78 |
GO:00512581 | Colorectum | SER | protein polymerization | 91/2897 | 297/18723 | 2.72e-11 | 5.06e-09 | 91 |
GO:00432541 | Colorectum | SER | regulation of protein-containing complex assembly | 119/2897 | 428/18723 | 3.34e-11 | 5.86e-09 | 119 |
GO:19029051 | Colorectum | SER | positive regulation of supramolecular fiber organization | 68/2897 | 209/18723 | 5.17e-10 | 5.98e-08 | 68 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TOGARAM1 | SNV | Missense_Mutation | novel | c.2908N>A | p.His970Asn | p.H970N | protein_coding | deleterious(0.02) | benign(0.023) | TCGA-86-8673-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
TOGARAM1 | SNV | Missense_Mutation | rs753984118 | c.1555N>G | p.Leu519Val | p.L519V | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-J2-A4AE-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TOGARAM1 | SNV | Missense_Mutation | novel | c.202G>C | p.Ala68Pro | p.A68P | protein_coding | deleterious_low_confidence(0.04) | benign(0.369) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TOGARAM1 | SNV | Missense_Mutation | novel | c.5098G>A | p.Glu1700Lys | p.E1700K | protein_coding | deleterious(0.05) | probably_damaging(0.945) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TOGARAM1 | SNV | Missense_Mutation | c.2623N>T | p.Asp875Tyr | p.D875Y | protein_coding | deleterious(0) | benign(0.136) | TCGA-MP-A4TC-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | CR | ||
TOGARAM1 | SNV | Missense_Mutation | c.2549N>T | p.Ser850Phe | p.S850F | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
TOGARAM1 | SNV | Missense_Mutation | c.4976N>T | p.Tyr1659Phe | p.Y1659F | protein_coding | tolerated(0.28) | possibly_damaging(0.699) | TCGA-18-3411-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
TOGARAM1 | SNV | Missense_Mutation | rs774550576 | c.835N>A | p.Ala279Thr | p.A279T | protein_coding | tolerated_low_confidence(0.58) | benign(0.006) | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TOGARAM1 | SNV | Missense_Mutation | novel | c.1688A>T | p.Asp563Val | p.D563V | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-22-1016-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TOGARAM1 | SNV | Missense_Mutation | novel | c.2197N>T | p.Ala733Ser | p.A733S | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-34-2605-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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