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Gene: TMEM131 |
Gene summary for TMEM131 |
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Gene information | Species | Human | Gene symbol | TMEM131 | Gene ID | 23505 |
Gene name | transmembrane protein 131 | |
Gene Alias | CC28 | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q92545 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23505 | TMEM131 | CCI_2 | Human | Cervix | CC | 2.37e-05 | 9.47e-01 | 0.5249 |
23505 | TMEM131 | CCI_3 | Human | Cervix | CC | 1.30e-05 | 6.44e-01 | 0.516 |
23505 | TMEM131 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.17e-26 | -7.74e-01 | 0.0155 |
23505 | TMEM131 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.18e-03 | -8.30e-01 | 0.0216 |
23505 | TMEM131 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.75e-10 | 4.99e-01 | -0.1954 |
23505 | TMEM131 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.25e-03 | -3.97e-01 | -0.1207 |
23505 | TMEM131 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.99e-04 | -4.68e-01 | -0.2061 |
23505 | TMEM131 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.76e-02 | -7.22e-01 | -0.00410000000000005 |
23505 | TMEM131 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.46e-02 | -5.40e-01 | -0.0179 |
23505 | TMEM131 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.02e-04 | -4.59e-01 | 0.096 |
23505 | TMEM131 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.62e-04 | -5.43e-01 | 0.0528 |
23505 | TMEM131 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.10e-05 | -5.77e-01 | 0.0338 |
23505 | TMEM131 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.06e-10 | -5.09e-01 | 0.0674 |
23505 | TMEM131 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.81e-04 | -6.59e-01 | 0.0112 |
23505 | TMEM131 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.94e-08 | -5.63e-01 | 0.0588 |
23505 | TMEM131 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.02e-06 | -3.91e-01 | 0.294 |
23505 | TMEM131 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.50e-03 | -3.46e-01 | 0.3859 |
23505 | TMEM131 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.99e-03 | -5.81e-01 | 0.2585 |
23505 | TMEM131 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.71e-21 | -6.54e-01 | 0.3005 |
23505 | TMEM131 | A001-C-207 | Human | Colorectum | FAP | 2.94e-02 | -1.84e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002240710 | Cervix | CC | regulation of cell-cell adhesion | 103/2311 | 448/18723 | 1.78e-10 | 2.87e-08 | 103 |
GO:00421108 | Cervix | CC | T cell activation | 107/2311 | 487/18723 | 1.24e-09 | 1.46e-07 | 107 |
GO:00508638 | Cervix | CC | regulation of T cell activation | 80/2311 | 329/18723 | 1.28e-09 | 1.47e-07 | 80 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:00071598 | Cervix | CC | leukocyte cell-cell adhesion | 85/2311 | 371/18723 | 8.27e-09 | 7.07e-07 | 85 |
GO:00071626 | Cervix | CC | negative regulation of cell adhesion | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:00026837 | Cervix | CC | negative regulation of immune system process | 94/2311 | 434/18723 | 2.63e-08 | 1.87e-06 | 94 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
GO:19030378 | Cervix | CC | regulation of leukocyte cell-cell adhesion | 77/2311 | 336/18723 | 4.08e-08 | 2.54e-06 | 77 |
GO:190370610 | Cervix | CC | regulation of hemopoiesis | 80/2311 | 367/18723 | 2.14e-07 | 9.55e-06 | 80 |
GO:00420988 | Cervix | CC | T cell proliferation | 49/2311 | 199/18723 | 1.32e-06 | 4.49e-05 | 49 |
GO:00608287 | Cervix | CC | regulation of canonical Wnt signaling pathway | 58/2311 | 253/18723 | 1.83e-06 | 5.89e-05 | 58 |
GO:00224084 | Cervix | CC | negative regulation of cell-cell adhesion | 48/2311 | 196/18723 | 1.99e-06 | 6.18e-05 | 48 |
GO:00600707 | Cervix | CC | canonical Wnt signaling pathway | 66/2311 | 303/18723 | 2.47e-06 | 7.35e-05 | 66 |
GO:00421297 | Cervix | CC | regulation of T cell proliferation | 43/2311 | 171/18723 | 3.21e-06 | 8.77e-05 | 43 |
GO:19021056 | Cervix | CC | regulation of leukocyte differentiation | 61/2311 | 279/18723 | 5.16e-06 | 1.29e-04 | 61 |
GO:00706637 | Cervix | CC | regulation of leukocyte proliferation | 55/2311 | 245/18723 | 6.51e-06 | 1.56e-04 | 55 |
GO:19021064 | Cervix | CC | negative regulation of leukocyte differentiation | 29/2311 | 102/18723 | 1.02e-05 | 2.29e-04 | 29 |
GO:00506705 | Cervix | CC | regulation of lymphocyte proliferation | 51/2311 | 225/18723 | 1.05e-05 | 2.32e-04 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM131 | SNV | Missense_Mutation | c.2661N>C | p.Leu887Phe | p.L887F | Q92545 | protein_coding | tolerated(0.13) | benign(0.383) | TCGA-EJ-7782-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD | |
TMEM131 | SNV | Missense_Mutation | c.1761C>G | p.Asp587Glu | p.D587E | Q92545 | protein_coding | tolerated(0.27) | benign(0.007) | TCGA-BR-4191-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | docetaxel | SD | |
TMEM131 | SNV | Missense_Mutation | c.4180N>T | p.Pro1394Ser | p.P1394S | Q92545 | protein_coding | tolerated_low_confidence(0.16) | benign(0.024) | TCGA-BR-6457-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Ancillary | leucovorin | CR | |
TMEM131 | SNV | Missense_Mutation | rs750202724 | c.5128G>A | p.Val1710Ile | p.V1710I | Q92545 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM131 | SNV | Missense_Mutation | c.4979C>A | p.Ala1660Asp | p.A1660D | Q92545 | protein_coding | deleterious_low_confidence(0) | benign(0.019) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TMEM131 | SNV | Missense_Mutation | rs61753932 | c.3235C>T | p.Arg1079Trp | p.R1079W | Q92545 | protein_coding | deleterious(0) | benign(0.019) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR |
TMEM131 | SNV | Missense_Mutation | c.1412T>C | p.Val471Ala | p.V471A | Q92545 | protein_coding | tolerated(0.07) | benign(0.007) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM131 | SNV | Missense_Mutation | rs201560485 | c.3800N>T | p.Ser1267Leu | p.S1267L | Q92545 | protein_coding | deleterious_low_confidence(0.05) | benign(0.023) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
TMEM131 | SNV | Missense_Mutation | c.1211N>G | p.Phe404Cys | p.F404C | Q92545 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
TMEM131 | SNV | Missense_Mutation | c.341T>C | p.Met114Thr | p.M114T | Q92545 | protein_coding | deleterious(0.02) | possibly_damaging(0.885) | TCGA-CD-A4MJ-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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