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Gene: TANC1 |
Gene summary for TANC1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TANC1 | Gene ID | 85461 |
Gene name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | |
Gene Alias | ROLSB | |
Cytomap | 2q24.2 | |
Gene Type | protein-coding | GO ID | GO:0000768 | UniProtAcc | B9EK39 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85461 | TANC1 | CA_HPV_1 | Human | Cervix | CC | 8.44e-05 | -1.88e-01 | 0.0264 |
85461 | TANC1 | CCI_1 | Human | Cervix | CC | 2.41e-19 | 1.45e+00 | 0.528 |
85461 | TANC1 | CCI_2 | Human | Cervix | CC | 2.27e-20 | 1.87e+00 | 0.5249 |
85461 | TANC1 | CCI_3 | Human | Cervix | CC | 2.93e-25 | 1.39e+00 | 0.516 |
85461 | TANC1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.67e-29 | -5.60e-01 | 0.0155 |
85461 | TANC1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.76e-03 | -2.37e-01 | -0.1808 |
85461 | TANC1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.77e-06 | -5.72e-01 | -0.1207 |
85461 | TANC1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.52e-07 | -4.87e-01 | 0.096 |
85461 | TANC1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.91e-04 | -4.93e-01 | 0.0528 |
85461 | TANC1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.85e-10 | -4.52e-01 | 0.0674 |
85461 | TANC1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.61e-04 | -3.22e-01 | 0.294 |
85461 | TANC1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.68e-10 | -4.73e-01 | 0.3005 |
85461 | TANC1 | F007 | Human | Colorectum | FAP | 4.20e-06 | -3.82e-01 | 0.1176 |
85461 | TANC1 | A001-C-207 | Human | Colorectum | FAP | 1.87e-03 | -1.76e-01 | 0.1278 |
85461 | TANC1 | A015-C-203 | Human | Colorectum | FAP | 4.08e-40 | -6.35e-01 | -0.1294 |
85461 | TANC1 | A015-C-204 | Human | Colorectum | FAP | 2.56e-08 | -3.39e-01 | -0.0228 |
85461 | TANC1 | A014-C-040 | Human | Colorectum | FAP | 7.90e-09 | -6.43e-01 | -0.1184 |
85461 | TANC1 | A002-C-201 | Human | Colorectum | FAP | 3.09e-17 | -4.05e-01 | 0.0324 |
85461 | TANC1 | A002-C-203 | Human | Colorectum | FAP | 2.58e-02 | -1.14e-01 | 0.2786 |
85461 | TANC1 | A001-C-119 | Human | Colorectum | FAP | 1.77e-07 | -3.57e-01 | -0.1557 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00093149 | Cervix | CC | response to radiation | 86/2311 | 456/18723 | 3.50e-05 | 5.63e-04 | 86 |
GO:00426924 | Cervix | CC | muscle cell differentiation | 69/2311 | 384/18723 | 8.12e-04 | 7.09e-03 | 69 |
GO:0000768 | Cervix | CC | syncytium formation by plasma membrane fusion | 15/2311 | 55/18723 | 2.14e-03 | 1.54e-02 | 15 |
GO:0140253 | Cervix | CC | cell-cell fusion | 15/2311 | 55/18723 | 2.14e-03 | 1.54e-02 | 15 |
GO:00069491 | Cervix | CC | syncytium formation | 15/2311 | 57/18723 | 3.13e-03 | 2.05e-02 | 15 |
GO:01060277 | Cervix | CC | neuron projection organization | 21/2311 | 93/18723 | 4.10e-03 | 2.54e-02 | 21 |
GO:00511464 | Cervix | CC | striated muscle cell differentiation | 50/2311 | 283/18723 | 5.53e-03 | 3.19e-02 | 50 |
GO:00094163 | Cervix | CC | response to light stimulus | 54/2311 | 320/18723 | 1.03e-02 | 4.97e-02 | 54 |
GO:0106027 | Colorectum | AD | neuron projection organization | 36/3918 | 93/18723 | 6.58e-05 | 1.07e-03 | 36 |
GO:0043954 | Colorectum | AD | cellular component maintenance | 26/3918 | 61/18723 | 1.04e-04 | 1.56e-03 | 26 |
GO:0097061 | Colorectum | AD | dendritic spine organization | 31/3918 | 84/18723 | 5.48e-04 | 5.83e-03 | 31 |
GO:0099173 | Colorectum | AD | postsynapse organization | 51/3918 | 168/18723 | 2.47e-03 | 1.90e-02 | 51 |
GO:0050808 | Colorectum | AD | synapse organization | 112/3918 | 426/18723 | 4.25e-03 | 2.92e-02 | 112 |
GO:0097062 | Colorectum | AD | dendritic spine maintenance | 10/3918 | 21/18723 | 5.71e-03 | 3.64e-02 | 10 |
GO:01060271 | Colorectum | SER | neuron projection organization | 33/2897 | 93/18723 | 1.64e-06 | 7.23e-05 | 33 |
GO:00970611 | Colorectum | SER | dendritic spine organization | 29/2897 | 84/18723 | 1.27e-05 | 4.01e-04 | 29 |
GO:00991731 | Colorectum | SER | postsynapse organization | 46/2897 | 168/18723 | 5.20e-05 | 1.25e-03 | 46 |
GO:00439541 | Colorectum | SER | cellular component maintenance | 22/2897 | 61/18723 | 6.47e-05 | 1.49e-03 | 22 |
GO:00970621 | Colorectum | SER | dendritic spine maintenance | 9/2897 | 21/18723 | 2.50e-03 | 2.33e-02 | 9 |
GO:00508081 | Colorectum | SER | synapse organization | 85/2897 | 426/18723 | 7.17e-03 | 4.99e-02 | 85 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TANC1 | SNV | Missense_Mutation | c.3008G>A | p.Cys1003Tyr | p.C1003Y | Q9C0D5 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
TANC1 | SNV | Missense_Mutation | c.3800N>A | p.Gly1267Glu | p.G1267E | Q9C0D5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | |
TANC1 | SNV | Missense_Mutation | rs765734612 | c.5192C>T | p.Ala1731Val | p.A1731V | Q9C0D5 | protein_coding | tolerated_low_confidence(0.08) | possibly_damaging(0.652) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TANC1 | SNV | Missense_Mutation | c.3155N>A | p.Gly1052Asp | p.G1052D | Q9C0D5 | protein_coding | deleterious(0.02) | probably_damaging(0.98) | TCGA-F1-6177-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TANC1 | SNV | Missense_Mutation | c.2600N>C | p.Leu867Pro | p.L867P | Q9C0D5 | protein_coding | deleterious(0.01) | possibly_damaging(0.557) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD | |
TANC1 | SNV | Missense_Mutation | c.2219N>G | p.Gln740Arg | p.Q740R | Q9C0D5 | protein_coding | deleterious(0.01) | possibly_damaging(0.824) | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR | |
TANC1 | SNV | Missense_Mutation | rs753195213 | c.550N>A | p.Ala184Thr | p.A184T | Q9C0D5 | protein_coding | tolerated(0.26) | benign(0.025) | TCGA-HU-8610-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TANC1 | SNV | Missense_Mutation | c.1264G>A | p.Ala422Thr | p.A422T | Q9C0D5 | protein_coding | deleterious(0) | possibly_damaging(0.816) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD | |
TANC1 | SNV | Missense_Mutation | rs747252852 | c.1916C>T | p.Ala639Val | p.A639V | Q9C0D5 | protein_coding | tolerated(0.29) | benign(0.007) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TANC1 | SNV | Missense_Mutation | novel | c.1412N>T | p.Ser471Ile | p.S471I | Q9C0D5 | protein_coding | deleterious(0.03) | benign(0.094) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
85461 | TANC1 | CLINICALLY ACTIONABLE | radiotherapy | 24974847 |
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