![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SYNPO2 |
Gene summary for SYNPO2 |
![]() |
Gene information | Species | Human | Gene symbol | SYNPO2 | Gene ID | 171024 |
Gene name | synaptopodin 2 | |
Gene Alias | SYNPO2 | |
Cytomap | 4q26 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q9UMS6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
171024 | SYNPO2 | CA_HPV_3 | Human | Cervix | CC | 1.09e-03 | 9.88e-02 | 0.0414 |
171024 | SYNPO2 | CCI_3 | Human | Cervix | CC | 1.75e-05 | 6.58e-01 | 0.516 |
171024 | SYNPO2 | P2T-E | Human | Esophagus | ESCC | 3.60e-39 | 7.50e-01 | 0.1177 |
171024 | SYNPO2 | P4T-E | Human | Esophagus | ESCC | 7.58e-11 | 2.29e-01 | 0.1323 |
171024 | SYNPO2 | P8T-E | Human | Esophagus | ESCC | 3.91e-05 | 1.61e-01 | 0.0889 |
171024 | SYNPO2 | P16T-E | Human | Esophagus | ESCC | 8.65e-16 | 4.15e-01 | 0.1153 |
171024 | SYNPO2 | P22T-E | Human | Esophagus | ESCC | 1.38e-02 | 2.25e-03 | 0.1236 |
171024 | SYNPO2 | P26T-E | Human | Esophagus | ESCC | 1.81e-20 | 4.50e-01 | 0.1276 |
171024 | SYNPO2 | P27T-E | Human | Esophagus | ESCC | 1.52e-04 | 1.59e-01 | 0.1055 |
171024 | SYNPO2 | P36T-E | Human | Esophagus | ESCC | 1.72e-03 | 1.02e-01 | 0.1187 |
171024 | SYNPO2 | P49T-E | Human | Esophagus | ESCC | 2.12e-02 | 1.60e-01 | 0.1768 |
171024 | SYNPO2 | P56T-E | Human | Esophagus | ESCC | 2.89e-05 | 1.36e+00 | 0.1613 |
171024 | SYNPO2 | P62T-E | Human | Esophagus | ESCC | 1.50e-13 | 3.60e-01 | 0.1302 |
171024 | SYNPO2 | P65T-E | Human | Esophagus | ESCC | 1.10e-02 | 1.29e-02 | 0.0978 |
171024 | SYNPO2 | P79T-E | Human | Esophagus | ESCC | 7.70e-11 | 3.06e-01 | 0.1154 |
171024 | SYNPO2 | P130T-E | Human | Esophagus | ESCC | 9.03e-10 | 2.68e-01 | 0.1676 |
171024 | SYNPO2 | C21 | Human | Oral cavity | OSCC | 3.23e-06 | -4.94e-01 | 0.2678 |
171024 | SYNPO2 | C38 | Human | Oral cavity | OSCC | 2.32e-02 | 7.35e-01 | 0.172 |
171024 | SYNPO2 | C43 | Human | Oral cavity | OSCC | 2.29e-06 | 3.76e-01 | 0.1704 |
171024 | SYNPO2 | C46 | Human | Oral cavity | OSCC | 2.16e-13 | 6.61e-01 | 0.1673 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:003297010 | Cervix | CC | regulation of actin filament-based process | 96/2311 | 397/18723 | 4.00e-11 | 8.54e-09 | 96 |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:003295610 | Cervix | CC | regulation of actin cytoskeleton organization | 86/2311 | 358/18723 | 5.90e-10 | 7.51e-08 | 86 |
GO:011005310 | Cervix | CC | regulation of actin filament organization | 67/2311 | 278/18723 | 4.01e-08 | 2.54e-06 | 67 |
GO:006157210 | Cervix | CC | actin filament bundle organization | 44/2311 | 161/18723 | 2.08e-07 | 9.34e-06 | 44 |
GO:005101710 | Cervix | CC | actin filament bundle assembly | 43/2311 | 157/18723 | 2.66e-07 | 1.12e-05 | 43 |
GO:190290510 | Cervix | CC | positive regulation of supramolecular fiber organization | 50/2311 | 209/18723 | 2.55e-06 | 7.54e-05 | 50 |
GO:005149510 | Cervix | CC | positive regulation of cytoskeleton organization | 50/2311 | 226/18723 | 2.53e-05 | 4.29e-04 | 50 |
GO:003223110 | Cervix | CC | regulation of actin filament bundle assembly | 28/2311 | 105/18723 | 5.19e-05 | 7.79e-04 | 28 |
GO:00162367 | Cervix | CC | macroautophagy | 58/2311 | 291/18723 | 1.40e-04 | 1.70e-03 | 58 |
GO:00616847 | Cervix | CC | chaperone-mediated autophagy | 8/2311 | 16/18723 | 2.73e-04 | 2.99e-03 | 8 |
GO:00322339 | Cervix | CC | positive regulation of actin filament bundle assembly | 18/2311 | 63/18723 | 4.39e-04 | 4.39e-03 | 18 |
GO:00000452 | Cervix | CC | autophagosome assembly | 21/2311 | 99/18723 | 8.67e-03 | 4.46e-02 | 21 |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:000703314 | Esophagus | ESCC | vacuole organization | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:1902905111 | Esophagus | ESCC | positive regulation of supramolecular fiber organization | 142/8552 | 209/18723 | 5.51e-11 | 1.76e-09 | 142 |
GO:1902903111 | Esophagus | ESCC | regulation of supramolecular fiber organization | 237/8552 | 383/18723 | 9.06e-11 | 2.75e-09 | 237 |
GO:005149520 | Esophagus | ESCC | positive regulation of cytoskeleton organization | 147/8552 | 226/18723 | 2.93e-09 | 6.38e-08 | 147 |
GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SYNPO2 | SNV | Missense_Mutation | c.3358G>A | p.Asp1120Asn | p.D1120N | Q9UMS6 | protein_coding | tolerated(0.42) | benign(0.01) | TCGA-D7-5577-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | calcium foliatum | PD | |
SYNPO2 | SNV | Missense_Mutation | c.2654A>G | p.Lys885Arg | p.K885R | Q9UMS6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR | |
SYNPO2 | SNV | Missense_Mutation | novel | c.1780G>A | p.Gly594Arg | p.G594R | Q9UMS6 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-HU-A4GH-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SYNPO2 | SNV | Missense_Mutation | novel | c.1067C>T | p.Ala356Val | p.A356V | Q9UMS6 | protein_coding | deleterious(0) | possibly_damaging(0.853) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
SYNPO2 | deletion | Frame_Shift_Del | novel | c.3300delC | p.Ile1101PhefsTer22 | p.I1101Ffs*22 | Q9UMS6 | protein_coding | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SYNPO2 | insertion | Frame_Shift_Ins | novel | c.1773_1774insTTCCCAG | p.Gly594ValfsTer24 | p.G594Vfs*24 | Q9UMS6 | protein_coding | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | ||
SYNPO2 | deletion | Frame_Shift_Del | novel | c.50delN | p.Phe19SerfsTer58 | p.F19Sfs*58 | Q9UMS6 | protein_coding | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SYNPO2 | SNV | Missense_Mutation | novel | c.76N>A | p.Glu26Lys | p.E26K | Q9UMS6 | protein_coding | deleterious(0.01) | possibly_damaging(0.669) | TCGA-E8-A438-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SYNPO2 | insertion | In_Frame_Ins | novel | c.89_90insAGGACA | p.Pro30_Leu31insGlyHis | p.P30_L31insGH | Q9UMS6 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |