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Gene: RAB3GAP2 |
Gene summary for RAB3GAP2 |
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Gene information | Species | Human | Gene symbol | RAB3GAP2 | Gene ID | 25782 |
Gene name | RAB3 GTPase activating non-catalytic protein subunit 2 | |
Gene Alias | MARTS1 | |
Cytomap | 1q41 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | Q9H2M9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25782 | RAB3GAP2 | CCI_1 | Human | Cervix | CC | 1.07e-07 | 1.05e+00 | 0.528 |
25782 | RAB3GAP2 | CCI_2 | Human | Cervix | CC | 4.99e-04 | 6.70e-01 | 0.5249 |
25782 | RAB3GAP2 | CCI_3 | Human | Cervix | CC | 1.62e-13 | 9.41e-01 | 0.516 |
25782 | RAB3GAP2 | LZE2T | Human | Esophagus | ESCC | 8.31e-06 | 3.77e-01 | 0.082 |
25782 | RAB3GAP2 | LZE4T | Human | Esophagus | ESCC | 6.55e-12 | 2.29e-01 | 0.0811 |
25782 | RAB3GAP2 | LZE5T | Human | Esophagus | ESCC | 8.85e-03 | 2.74e-01 | 0.0514 |
25782 | RAB3GAP2 | LZE7T | Human | Esophagus | ESCC | 4.65e-13 | 5.44e-01 | 0.0667 |
25782 | RAB3GAP2 | LZE24T | Human | Esophagus | ESCC | 1.92e-21 | 3.26e-01 | 0.0596 |
25782 | RAB3GAP2 | LZE21T | Human | Esophagus | ESCC | 4.27e-07 | 2.55e-01 | 0.0655 |
25782 | RAB3GAP2 | P1T-E | Human | Esophagus | ESCC | 2.18e-18 | 5.95e-01 | 0.0875 |
25782 | RAB3GAP2 | P2T-E | Human | Esophagus | ESCC | 9.39e-28 | 3.55e-01 | 0.1177 |
25782 | RAB3GAP2 | P4T-E | Human | Esophagus | ESCC | 9.32e-12 | 1.40e-01 | 0.1323 |
25782 | RAB3GAP2 | P5T-E | Human | Esophagus | ESCC | 5.02e-09 | 1.96e-01 | 0.1327 |
25782 | RAB3GAP2 | P8T-E | Human | Esophagus | ESCC | 4.89e-17 | 3.56e-01 | 0.0889 |
25782 | RAB3GAP2 | P9T-E | Human | Esophagus | ESCC | 1.96e-14 | 2.32e-01 | 0.1131 |
25782 | RAB3GAP2 | P10T-E | Human | Esophagus | ESCC | 8.06e-17 | 3.63e-01 | 0.116 |
25782 | RAB3GAP2 | P11T-E | Human | Esophagus | ESCC | 2.93e-10 | 3.89e-01 | 0.1426 |
25782 | RAB3GAP2 | P12T-E | Human | Esophagus | ESCC | 2.20e-12 | 1.93e-01 | 0.1122 |
25782 | RAB3GAP2 | P15T-E | Human | Esophagus | ESCC | 1.99e-22 | 3.88e-01 | 0.1149 |
25782 | RAB3GAP2 | P16T-E | Human | Esophagus | ESCC | 1.07e-25 | 2.93e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00725949 | Cervix | CC | establishment of protein localization to organelle | 99/2311 | 422/18723 | 1.23e-10 | 2.11e-08 | 99 |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:00430877 | Cervix | CC | regulation of GTPase activity | 79/2311 | 348/18723 | 4.21e-08 | 2.60e-06 | 79 |
GO:003133110 | Cervix | CC | positive regulation of cellular catabolic process | 91/2311 | 427/18723 | 9.64e-08 | 5.25e-06 | 91 |
GO:00901509 | Cervix | CC | establishment of protein localization to membrane | 54/2311 | 260/18723 | 7.67e-05 | 1.05e-03 | 54 |
GO:00162367 | Cervix | CC | macroautophagy | 58/2311 | 291/18723 | 1.40e-04 | 1.70e-03 | 58 |
GO:00709726 | Cervix | CC | protein localization to endoplasmic reticulum | 21/2311 | 74/18723 | 1.69e-04 | 2.00e-03 | 21 |
GO:00105067 | Cervix | CC | regulation of autophagy | 61/2311 | 317/18723 | 2.61e-04 | 2.87e-03 | 61 |
GO:19021153 | Cervix | CC | regulation of organelle assembly | 40/2311 | 186/18723 | 2.92e-04 | 3.15e-03 | 40 |
GO:19021171 | Cervix | CC | positive regulation of organelle assembly | 19/2311 | 67/18723 | 3.42e-04 | 3.58e-03 | 19 |
GO:00725995 | Cervix | CC | establishment of protein localization to endoplasmic reticulum | 13/2311 | 46/18723 | 2.95e-03 | 1.94e-02 | 13 |
GO:00000452 | Cervix | CC | autophagosome assembly | 21/2311 | 99/18723 | 8.67e-03 | 4.46e-02 | 21 |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
GO:001050617 | Esophagus | ESCC | regulation of autophagy | 220/8552 | 317/18723 | 6.72e-18 | 6.36e-16 | 220 |
GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
GO:000703314 | Esophagus | ESCC | vacuole organization | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:001624114 | Esophagus | ESCC | regulation of macroautophagy | 102/8552 | 141/18723 | 1.09e-10 | 3.27e-09 | 102 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAB3GAP2 | deletion | Frame_Shift_Del | novel | c.4113delN | p.Lys1371AsnfsTer7 | p.K1371Nfs*7 | Q9H2M9 | protein_coding | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
RAB3GAP2 | deletion | Frame_Shift_Del | c.3102delN | p.Phe1034LeufsTer5 | p.F1034Lfs*5 | Q9H2M9 | protein_coding | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD | |||
RAB3GAP2 | deletion | Frame_Shift_Del | c.3102delT | p.Phe1034LeufsTer5 | p.F1034Lfs*5 | Q9H2M9 | protein_coding | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |||
RAB3GAP2 | deletion | Frame_Shift_Del | c.3563delN | p.Asn1188MetfsTer7 | p.N1188Mfs*7 | Q9H2M9 | protein_coding | TCGA-VQ-A8PO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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