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Gene: PLG |
Gene summary for PLG |
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Gene information | Species | Human | Gene symbol | PLG | Gene ID | 5340 |
Gene name | plasminogen | |
Gene Alias | HAE4 | |
Cytomap | 6q26 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P00747 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5340 | PLG | NAFLD1 | Human | Liver | NAFLD | 2.69e-16 | 1.45e+00 | -0.04 |
5340 | PLG | S41 | Human | Liver | Cirrhotic | 2.20e-08 | 8.92e-01 | -0.0343 |
5340 | PLG | S42 | Human | Liver | HCC | 2.55e-03 | 6.10e-01 | -0.0103 |
5340 | PLG | S43 | Human | Liver | Cirrhotic | 1.65e-06 | 1.62e-01 | -0.0187 |
5340 | PLG | HCC1_Meng | Human | Liver | HCC | 6.67e-115 | 4.79e-01 | 0.0246 |
5340 | PLG | HCC2_Meng | Human | Liver | HCC | 2.59e-11 | -3.90e-01 | 0.0107 |
5340 | PLG | cirrhotic1 | Human | Liver | Cirrhotic | 1.79e-09 | -3.46e-01 | 0.0202 |
5340 | PLG | cirrhotic2 | Human | Liver | Cirrhotic | 4.94e-10 | -2.99e-01 | 0.0201 |
5340 | PLG | cirrhotic3 | Human | Liver | Cirrhotic | 1.53e-03 | -3.62e-01 | 0.0215 |
5340 | PLG | HCC1 | Human | Liver | HCC | 2.47e-44 | 5.98e+00 | 0.5336 |
5340 | PLG | HCC2 | Human | Liver | HCC | 1.05e-26 | 3.63e+00 | 0.5341 |
5340 | PLG | Pt13.a | Human | Liver | HCC | 6.81e-09 | -1.08e-01 | 0.021 |
5340 | PLG | Pt13.b | Human | Liver | HCC | 8.49e-09 | -2.65e-01 | 0.0251 |
5340 | PLG | Pt14.a | Human | Liver | HCC | 1.55e-06 | 1.26e-02 | 0.0169 |
5340 | PLG | Pt14.b | Human | Liver | HCC | 1.33e-08 | -3.04e-02 | 0.018 |
5340 | PLG | Pt14.d | Human | Liver | HCC | 8.30e-07 | -1.70e-01 | 0.0143 |
5340 | PLG | S016 | Human | Liver | HCC | 4.69e-10 | -3.51e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045862111 | Esophagus | ESCC | positive regulation of proteolysis | 256/8552 | 372/18723 | 7.88e-20 | 9.43e-18 | 256 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
GO:00610417 | Liver | NAFLD | regulation of wound healing | 39/1882 | 134/18723 | 5.52e-10 | 1.28e-07 | 39 |
GO:00420607 | Liver | NAFLD | wound healing | 84/1882 | 422/18723 | 6.56e-10 | 1.37e-07 | 84 |
GO:0042730 | Liver | NAFLD | fibrinolysis | 15/1882 | 25/18723 | 1.26e-09 | 2.30e-07 | 15 |
GO:0030195 | Liver | NAFLD | negative regulation of blood coagulation | 21/1882 | 49/18723 | 2.42e-09 | 4.05e-07 | 21 |
GO:1900047 | Liver | NAFLD | negative regulation of hemostasis | 21/1882 | 50/18723 | 3.78e-09 | 5.40e-07 | 21 |
GO:0030193 | Liver | NAFLD | regulation of blood coagulation | 24/1882 | 66/18723 | 9.30e-09 | 1.26e-06 | 24 |
GO:0050819 | Liver | NAFLD | negative regulation of coagulation | 21/1882 | 53/18723 | 1.33e-08 | 1.69e-06 | 21 |
GO:1900046 | Liver | NAFLD | regulation of hemostasis | 24/1882 | 68/18723 | 1.84e-08 | 2.09e-06 | 24 |
GO:0061045 | Liver | NAFLD | negative regulation of wound healing | 26/1882 | 78/18723 | 1.86e-08 | 2.09e-06 | 26 |
GO:19030347 | Liver | NAFLD | regulation of response to wounding | 41/1882 | 167/18723 | 4.70e-08 | 4.58e-06 | 41 |
GO:0050818 | Liver | NAFLD | regulation of coagulation | 24/1882 | 71/18723 | 4.80e-08 | 4.60e-06 | 24 |
GO:0051917 | Liver | NAFLD | regulation of fibrinolysis | 10/1882 | 14/18723 | 7.05e-08 | 6.34e-06 | 10 |
GO:00075994 | Liver | NAFLD | hemostasis | 49/1882 | 222/18723 | 9.23e-08 | 7.59e-06 | 49 |
GO:00075964 | Liver | NAFLD | blood coagulation | 48/1882 | 217/18723 | 1.16e-07 | 8.81e-06 | 48 |
GO:00508174 | Liver | NAFLD | coagulation | 48/1882 | 222/18723 | 2.40e-07 | 1.61e-05 | 48 |
GO:00108107 | Liver | NAFLD | regulation of cell-substrate adhesion | 47/1882 | 221/18723 | 5.30e-07 | 3.16e-05 | 47 |
GO:00903035 | Liver | NAFLD | positive regulation of wound healing | 20/1882 | 59/18723 | 5.91e-07 | 3.46e-05 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04610 | Liver | NAFLD | Complement and coagulation cascades | 35/1043 | 86/8465 | 2.48e-11 | 2.04e-09 | 1.64e-09 | 35 |
hsa046101 | Liver | NAFLD | Complement and coagulation cascades | 35/1043 | 86/8465 | 2.48e-11 | 2.04e-09 | 1.64e-09 | 35 |
hsa046102 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa0516410 | Liver | Cirrhotic | Influenza A | 66/2530 | 171/8465 | 8.56e-03 | 2.91e-02 | 1.79e-02 | 66 |
hsa046103 | Liver | Cirrhotic | Complement and coagulation cascades | 48/2530 | 86/8465 | 4.41e-07 | 5.44e-06 | 3.35e-06 | 48 |
hsa0516411 | Liver | Cirrhotic | Influenza A | 66/2530 | 171/8465 | 8.56e-03 | 2.91e-02 | 1.79e-02 | 66 |
hsa046104 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
hsa0516421 | Liver | HCC | Influenza A | 101/4020 | 171/8465 | 1.41e-03 | 5.07e-03 | 2.82e-03 | 101 |
hsa046105 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
hsa0516431 | Liver | HCC | Influenza A | 101/4020 | 171/8465 | 1.41e-03 | 5.07e-03 | 2.82e-03 | 101 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
PLG | F2R | PLG_F2R | PARs | Liver | Healthy |
PLG | PARD3 | PLG_PARD3 | PARs | Liver | Healthy |
PLG | F2R | PLG_F2R | PARs | Liver | Precancer |
PLG | PARD3 | PLG_PARD3 | PARs | Liver | Precancer |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLG | SNV | Missense_Mutation | c.2322A>C | p.Leu774Phe | p.L774F | P00747 | protein_coding | deleterious(0.02) | probably_damaging(0.965) | TCGA-CG-4438-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
PLG | SNV | Missense_Mutation | c.2075N>C | p.Val692Ala | p.V692A | P00747 | protein_coding | deleterious(0.03) | benign(0.292) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
PLG | SNV | Missense_Mutation | c.546N>C | p.Glu182Asp | p.E182D | P00747 | protein_coding | tolerated(0.07) | benign(0.334) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PLG | SNV | Missense_Mutation | c.1838N>T | p.Ser613Phe | p.S613F | P00747 | protein_coding | tolerated(0.08) | possibly_damaging(0.703) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PLG | SNV | Missense_Mutation | c.646G>T | p.Ala216Ser | p.A216S | P00747 | protein_coding | tolerated(0.91) | benign(0.012) | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLG | SNV | Missense_Mutation | rs574500945 | c.1330G>A | p.Val444Ile | p.V444I | P00747 | protein_coding | deleterious(0.04) | benign(0.327) | TCGA-HU-A4GY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PLG | SNV | Missense_Mutation | novel | c.719A>G | p.Glu240Gly | p.E240G | P00747 | protein_coding | deleterious(0) | possibly_damaging(0.894) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PLG | insertion | Frame_Shift_Ins | novel | c.393_394insC | p.His133ProfsTer4 | p.H133Pfs*4 | P00747 | protein_coding | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | ||
PLG | insertion | Frame_Shift_Ins | novel | c.919_920dupCA | p.Asn308IlefsTer64 | p.N308Ifs*64 | P00747 | protein_coding | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | UROKINASE | UROKINASE | ||
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | ALTEPLASE | ALTEPLASE | ||
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | ALTEPLASE | ALTEPLASE | ||
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | DESMOTEPLASE | DESMOTEPLASE | ||
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | Reteplase | RETEPLASE | ||
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | NYSTATIN | NYSTATIN | 7721938 | |
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | ANISTREPLASE | ANISTREPLASE | ||
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | RETEPLASE | RETEPLASE | ||
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | BORTEZOMIB | BORTEZOMIB | 20875739 | |
5340 | PLG | DRUGGABLE GENOME, ENZYME, CELL SURFACE, PROTEASE | ANTIDEPRESSANTS | 16890384 |
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