![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PEAK1 |
Gene summary for PEAK1 |
![]() |
Gene information | Species | Human | Gene symbol | PEAK1 | Gene ID | 79834 |
Gene name | pseudopodium enriched atypical kinase 1 | |
Gene Alias | SGK269 | |
Cytomap | 15q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9H792 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79834 | PEAK1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.19e-27 | -8.33e-01 | 0.0155 |
79834 | PEAK1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.51e-04 | -8.66e-01 | 0.0216 |
79834 | PEAK1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.10e-10 | -5.69e-01 | -0.1207 |
79834 | PEAK1 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.79e-06 | -3.28e-01 | -0.1464 |
79834 | PEAK1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.99e-03 | -6.37e-01 | -0.0179 |
79834 | PEAK1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.18e-17 | -7.33e-01 | 0.096 |
79834 | PEAK1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.46e-02 | -8.19e-01 | 0.0451 |
79834 | PEAK1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.17e-08 | -8.42e-01 | 0.0528 |
79834 | PEAK1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.65e-07 | -5.15e-01 | 0.0338 |
79834 | PEAK1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.72e-23 | -7.06e-01 | 0.0674 |
79834 | PEAK1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.35e-04 | -4.97e-01 | 0.0112 |
79834 | PEAK1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.11e-07 | -6.09e-01 | 0.0588 |
79834 | PEAK1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.02e-43 | -7.81e-01 | 0.294 |
79834 | PEAK1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.06e-40 | -8.08e-01 | 0.3859 |
79834 | PEAK1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.84e-07 | -7.54e-01 | 0.2585 |
79834 | PEAK1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.40e-48 | -9.23e-01 | 0.3005 |
79834 | PEAK1 | A002-C-010 | Human | Colorectum | FAP | 5.45e-03 | -2.39e-01 | 0.242 |
79834 | PEAK1 | A001-C-207 | Human | Colorectum | FAP | 8.86e-03 | -2.81e-01 | 0.1278 |
79834 | PEAK1 | A015-C-203 | Human | Colorectum | FAP | 4.98e-45 | -7.26e-01 | -0.1294 |
79834 | PEAK1 | A015-C-204 | Human | Colorectum | FAP | 1.03e-05 | -3.64e-01 | -0.0228 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0010810 | Colorectum | AD | regulation of cell-substrate adhesion | 81/3918 | 221/18723 | 4.80e-08 | 2.55e-06 | 81 |
GO:0150115 | Colorectum | AD | cell-substrate junction organization | 44/3918 | 101/18723 | 2.38e-07 | 9.81e-06 | 44 |
GO:0031589 | Colorectum | AD | cell-substrate adhesion | 116/3918 | 363/18723 | 4.68e-07 | 1.76e-05 | 116 |
GO:0007044 | Colorectum | AD | cell-substrate junction assembly | 41/3918 | 95/18723 | 8.20e-07 | 2.85e-05 | 41 |
GO:0001952 | Colorectum | AD | regulation of cell-matrix adhesion | 50/3918 | 128/18723 | 2.05e-06 | 6.05e-05 | 50 |
GO:0046777 | Colorectum | AD | protein autophosphorylation | 74/3918 | 227/18723 | 2.48e-05 | 4.76e-04 | 74 |
GO:0007160 | Colorectum | AD | cell-matrix adhesion | 75/3918 | 233/18723 | 3.56e-05 | 6.45e-04 | 75 |
GO:0048041 | Colorectum | AD | focal adhesion assembly | 34/3918 | 87/18723 | 8.30e-05 | 1.30e-03 | 34 |
GO:0034446 | Colorectum | AD | substrate adhesion-dependent cell spreading | 40/3918 | 108/18723 | 8.52e-05 | 1.32e-03 | 40 |
GO:0150116 | Colorectum | AD | regulation of cell-substrate junction organization | 28/3918 | 71/18723 | 2.85e-04 | 3.48e-03 | 28 |
GO:0051893 | Colorectum | AD | regulation of focal adhesion assembly | 25/3918 | 66/18723 | 1.18e-03 | 1.06e-02 | 25 |
GO:0090109 | Colorectum | AD | regulation of cell-substrate junction assembly | 25/3918 | 66/18723 | 1.18e-03 | 1.06e-02 | 25 |
GO:1901888 | Colorectum | AD | regulation of cell junction assembly | 61/3918 | 204/18723 | 1.50e-03 | 1.27e-02 | 61 |
GO:00108101 | Colorectum | SER | regulation of cell-substrate adhesion | 64/2897 | 221/18723 | 2.34e-07 | 1.29e-05 | 64 |
GO:00343291 | Colorectum | SER | cell junction assembly | 100/2897 | 420/18723 | 4.23e-06 | 1.61e-04 | 100 |
GO:01501151 | Colorectum | SER | cell-substrate junction organization | 34/2897 | 101/18723 | 4.46e-06 | 1.67e-04 | 34 |
GO:00467771 | Colorectum | SER | protein autophosphorylation | 60/2897 | 227/18723 | 1.36e-05 | 4.25e-04 | 60 |
GO:00019521 | Colorectum | SER | regulation of cell-matrix adhesion | 39/2897 | 128/18723 | 1.39e-05 | 4.30e-04 | 39 |
GO:00070441 | Colorectum | SER | cell-substrate junction assembly | 31/2897 | 95/18723 | 2.34e-05 | 6.64e-04 | 31 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PEAK1 | deletion | Nonsense_Mutation | novel | c.4173_4189delNNNNNNNNNNNNNNNNN | p.Cys1391Ter | p.C1391* | Q9H792 | protein_coding | TCGA-EJ-5495-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD | ||
PEAK1 | SNV | Missense_Mutation | c.4054N>T | p.Pro1352Ser | p.P1352S | Q9H792 | protein_coding | deleterious(0.04) | probably_damaging(0.946) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PEAK1 | SNV | Missense_Mutation | c.4601N>G | p.Gln1534Arg | p.Q1534R | Q9H792 | protein_coding | tolerated(0.53) | benign(0.001) | TCGA-BR-8368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PEAK1 | SNV | Missense_Mutation | rs759331417 | c.890N>A | p.Arg297Gln | p.R297Q | Q9H792 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
PEAK1 | SNV | Missense_Mutation | c.3134N>G | p.Leu1045Arg | p.L1045R | Q9H792 | protein_coding | tolerated(0.21) | benign(0.166) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
PEAK1 | SNV | Missense_Mutation | rs536431798 | c.1843A>G | p.Thr615Ala | p.T615A | Q9H792 | protein_coding | tolerated(0.46) | benign(0) | TCGA-BR-A4J8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR |
PEAK1 | SNV | Missense_Mutation | c.4246N>C | p.Asp1416His | p.D1416H | Q9H792 | protein_coding | deleterious(0.02) | benign(0.201) | TCGA-CG-4436-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PEAK1 | SNV | Missense_Mutation | c.700G>A | p.Glu234Lys | p.E234K | Q9H792 | protein_coding | tolerated(0.11) | benign(0.174) | TCGA-CG-5718-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PEAK1 | SNV | Missense_Mutation | c.1918A>G | p.Ile640Val | p.I640V | Q9H792 | protein_coding | tolerated(0.72) | benign(0.019) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
PEAK1 | SNV | Missense_Mutation | c.266T>C | p.Leu89Pro | p.L89P | Q9H792 | protein_coding | deleterious(0.01) | benign(0.03) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |