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Gene: NUP153 |
Gene summary for NUP153 |
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Gene information | Species | Human | Gene symbol | NUP153 | Gene ID | 9972 |
Gene name | nucleoporin 153 | |
Gene Alias | HNUP153 | |
Cytomap | 6p22.3 | |
Gene Type | protein-coding | GO ID | GO:0006403 | UniProtAcc | P49790 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9972 | NUP153 | CCI_1 | Human | Cervix | CC | 8.96e-08 | 7.23e-01 | 0.528 |
9972 | NUP153 | CCI_2 | Human | Cervix | CC | 1.32e-11 | 9.90e-01 | 0.5249 |
9972 | NUP153 | CCI_3 | Human | Cervix | CC | 3.50e-05 | 5.64e-01 | 0.516 |
9972 | NUP153 | AEH-subject1 | Human | Endometrium | AEH | 5.36e-09 | 3.54e-01 | -0.3059 |
9972 | NUP153 | AEH-subject4 | Human | Endometrium | AEH | 3.23e-13 | 4.97e-01 | -0.2657 |
9972 | NUP153 | AEH-subject5 | Human | Endometrium | AEH | 1.09e-27 | 7.09e-01 | -0.2953 |
9972 | NUP153 | EEC-subject1 | Human | Endometrium | EEC | 6.27e-11 | 4.73e-01 | -0.2682 |
9972 | NUP153 | EEC-subject5 | Human | Endometrium | EEC | 4.27e-04 | 3.20e-01 | -0.249 |
9972 | NUP153 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 5.82e-03 | 3.14e-02 | -0.1869 |
9972 | NUP153 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 9.94e-04 | 1.63e-02 | -0.1883 |
9972 | NUP153 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 2.52e-02 | 5.53e-02 | -0.1934 |
9972 | NUP153 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.93e-04 | 1.74e-02 | -0.1917 |
9972 | NUP153 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 4.22e-07 | 7.15e-02 | -0.1916 |
9972 | NUP153 | LZE4T | Human | Esophagus | ESCC | 4.87e-03 | 6.26e-02 | 0.0811 |
9972 | NUP153 | LZE7T | Human | Esophagus | ESCC | 9.80e-08 | 6.12e-01 | 0.0667 |
9972 | NUP153 | LZE8T | Human | Esophagus | ESCC | 4.59e-09 | 1.96e-02 | 0.067 |
9972 | NUP153 | LZE22T | Human | Esophagus | ESCC | 9.13e-03 | 1.17e-01 | 0.068 |
9972 | NUP153 | LZE24T | Human | Esophagus | ESCC | 3.95e-03 | 1.09e-01 | 0.0596 |
9972 | NUP153 | P1T-E | Human | Esophagus | ESCC | 1.80e-02 | 3.10e-01 | 0.0875 |
9972 | NUP153 | P2T-E | Human | Esophagus | ESCC | 1.73e-24 | 5.16e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603210 | Cervix | CC | viral process | 109/2311 | 415/18723 | 5.40e-15 | 6.46e-12 | 109 |
GO:001905810 | Cervix | CC | viral life cycle | 87/2311 | 317/18723 | 2.20e-13 | 1.20e-10 | 87 |
GO:00725949 | Cervix | CC | establishment of protein localization to organelle | 99/2311 | 422/18723 | 1.23e-10 | 2.11e-08 | 99 |
GO:005212610 | Cervix | CC | movement in host environment | 52/2311 | 175/18723 | 7.03e-10 | 8.76e-08 | 52 |
GO:004440910 | Cervix | CC | entry into host | 47/2311 | 151/18723 | 8.45e-10 | 1.03e-07 | 47 |
GO:005170110 | Cervix | CC | biological process involved in interaction with host | 57/2311 | 203/18723 | 1.18e-09 | 1.41e-07 | 57 |
GO:004671810 | Cervix | CC | viral entry into host cell | 44/2311 | 144/18723 | 5.47e-09 | 5.03e-07 | 44 |
GO:004440310 | Cervix | CC | biological process involved in symbiotic interaction | 71/2311 | 290/18723 | 7.94e-09 | 6.98e-07 | 71 |
GO:00069139 | Cervix | CC | nucleocytoplasmic transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00511699 | Cervix | CC | nuclear transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:00468229 | Cervix | CC | regulation of nucleocytoplasmic transport | 31/2311 | 106/18723 | 2.68e-06 | 7.87e-05 | 31 |
GO:00323868 | Cervix | CC | regulation of intracellular transport | 71/2311 | 337/18723 | 3.70e-06 | 9.74e-05 | 71 |
GO:00170388 | Cervix | CC | protein import | 48/2311 | 206/18723 | 8.62e-06 | 1.98e-04 | 48 |
GO:00511689 | Cervix | CC | nuclear export | 38/2311 | 154/18723 | 1.86e-05 | 3.46e-04 | 38 |
GO:00511707 | Cervix | CC | import into nucleus | 38/2311 | 159/18723 | 3.98e-05 | 6.18e-04 | 38 |
GO:00512368 | Cervix | CC | establishment of RNA localization | 39/2311 | 166/18723 | 4.76e-05 | 7.25e-04 | 39 |
GO:00066067 | Cervix | CC | protein import into nucleus | 37/2311 | 155/18723 | 5.13e-05 | 7.71e-04 | 37 |
GO:00506578 | Cervix | CC | nucleic acid transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:00506588 | Cervix | CC | RNA transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501418 | Cervix | CC | Amyotrophic lateral sclerosis | 103/1267 | 364/8465 | 1.79e-11 | 4.47e-10 | 2.64e-10 | 103 |
hsa0501419 | Cervix | CC | Amyotrophic lateral sclerosis | 103/1267 | 364/8465 | 1.79e-11 | 4.47e-10 | 2.64e-10 | 103 |
hsa0501420 | Endometrium | AEH | Amyotrophic lateral sclerosis | 123/1197 | 364/8465 | 2.17e-22 | 7.82e-21 | 5.72e-21 | 123 |
hsa05014110 | Endometrium | AEH | Amyotrophic lateral sclerosis | 123/1197 | 364/8465 | 2.17e-22 | 7.82e-21 | 5.72e-21 | 123 |
hsa0501425 | Endometrium | EEC | Amyotrophic lateral sclerosis | 128/1237 | 364/8465 | 9.83e-24 | 4.04e-22 | 3.01e-22 | 128 |
hsa0501435 | Endometrium | EEC | Amyotrophic lateral sclerosis | 128/1237 | 364/8465 | 9.83e-24 | 4.04e-22 | 3.01e-22 | 128 |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa032509 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0325014 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0501414 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0501415 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa032502 | Liver | HCC | Viral life cycle - HIV-1 | 46/4020 | 63/8465 | 3.25e-05 | 1.88e-04 | 1.04e-04 | 46 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa0325011 | Liver | HCC | Viral life cycle - HIV-1 | 46/4020 | 63/8465 | 3.25e-05 | 1.88e-04 | 1.04e-04 | 46 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUP153 | SNV | Missense_Mutation | rs112957894 | c.1129N>G | p.Thr377Ala | p.T377A | P49790 | protein_coding | tolerated(1) | benign(0.005) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR |
NUP153 | SNV | Missense_Mutation | novel | c.2362G>T | p.Ala788Ser | p.A788S | P49790 | protein_coding | tolerated(0.5) | benign(0.068) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
NUP153 | SNV | Missense_Mutation | rs774114606 | c.230G>A | p.Arg77His | p.R77H | P49790 | protein_coding | tolerated(0.49) | benign(0) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
NUP153 | SNV | Missense_Mutation | novel | c.2234N>A | p.Gly745Asp | p.G745D | P49790 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
NUP153 | insertion | Frame_Shift_Ins | novel | c.4208dupC | p.Val1404CysfsTer7 | p.V1404Cfs*7 | P49790 | protein_coding | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NUP153 | deletion | In_Frame_Del | novel | c.514_531delTCTACCTCTCAGCATGAT | p.Ser172_Asp177del | p.S172_D177del | P49790 | protein_coding | TCGA-D7-A4YT-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
NUP153 | insertion | Nonsense_Mutation | novel | c.3641_3642insCTGAG | p.Gln1214HisfsTer2 | p.Q1214Hfs*2 | P49790 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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