![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MCM3AP |
Gene summary for MCM3AP |
![]() |
Gene information | Species | Human | Gene symbol | MCM3AP | Gene ID | 8888 |
Gene name | minichromosome maintenance complex component 3 associated protein | |
Gene Alias | GANP | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | GO:0002200 | UniProtAcc | O60318 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8888 | MCM3AP | LZE4T | Human | Esophagus | ESCC | 2.68e-03 | 1.26e-01 | 0.0811 |
8888 | MCM3AP | LZE22T | Human | Esophagus | ESCC | 4.19e-03 | 2.72e-01 | 0.068 |
8888 | MCM3AP | LZE24T | Human | Esophagus | ESCC | 4.67e-19 | 5.72e-01 | 0.0596 |
8888 | MCM3AP | P1T-E | Human | Esophagus | ESCC | 3.70e-09 | 2.77e-01 | 0.0875 |
8888 | MCM3AP | P2T-E | Human | Esophagus | ESCC | 4.52e-10 | 2.15e-01 | 0.1177 |
8888 | MCM3AP | P4T-E | Human | Esophagus | ESCC | 3.24e-08 | 2.49e-01 | 0.1323 |
8888 | MCM3AP | P5T-E | Human | Esophagus | ESCC | 7.85e-14 | 1.10e-01 | 0.1327 |
8888 | MCM3AP | P8T-E | Human | Esophagus | ESCC | 8.51e-09 | 1.67e-01 | 0.0889 |
8888 | MCM3AP | P10T-E | Human | Esophagus | ESCC | 4.20e-20 | 3.14e-01 | 0.116 |
8888 | MCM3AP | P11T-E | Human | Esophagus | ESCC | 1.42e-08 | 4.42e-01 | 0.1426 |
8888 | MCM3AP | P12T-E | Human | Esophagus | ESCC | 3.43e-12 | 2.33e-01 | 0.1122 |
8888 | MCM3AP | P15T-E | Human | Esophagus | ESCC | 1.48e-08 | 1.61e-01 | 0.1149 |
8888 | MCM3AP | P16T-E | Human | Esophagus | ESCC | 2.84e-19 | 2.82e-01 | 0.1153 |
8888 | MCM3AP | P20T-E | Human | Esophagus | ESCC | 2.32e-07 | 1.42e-01 | 0.1124 |
8888 | MCM3AP | P21T-E | Human | Esophagus | ESCC | 2.02e-16 | 2.96e-01 | 0.1617 |
8888 | MCM3AP | P22T-E | Human | Esophagus | ESCC | 5.28e-12 | 2.55e-01 | 0.1236 |
8888 | MCM3AP | P23T-E | Human | Esophagus | ESCC | 2.51e-08 | 2.54e-01 | 0.108 |
8888 | MCM3AP | P24T-E | Human | Esophagus | ESCC | 1.79e-07 | 1.91e-01 | 0.1287 |
8888 | MCM3AP | P26T-E | Human | Esophagus | ESCC | 1.54e-06 | 1.80e-01 | 0.1276 |
8888 | MCM3AP | P27T-E | Human | Esophagus | ESCC | 2.46e-13 | 2.78e-01 | 0.1055 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:005123617 | Esophagus | ESCC | establishment of RNA localization | 134/8552 | 166/18723 | 1.23e-20 | 1.81e-18 | 134 |
GO:0051168110 | Esophagus | ESCC | nuclear export | 126/8552 | 154/18723 | 1.88e-20 | 2.65e-18 | 126 |
GO:005102815 | Esophagus | ESCC | mRNA transport | 110/8552 | 130/18723 | 2.76e-20 | 3.80e-18 | 110 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:005065717 | Esophagus | ESCC | nucleic acid transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:005065817 | Esophagus | ESCC | RNA transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
GO:007116612 | Esophagus | ESCC | ribonucleoprotein complex localization | 66/8552 | 77/18723 | 2.94e-13 | 1.38e-11 | 66 |
GO:007142612 | Esophagus | ESCC | ribonucleoprotein complex export from nucleus | 65/8552 | 76/18723 | 5.56e-13 | 2.50e-11 | 65 |
GO:001839413 | Esophagus | ESCC | peptidyl-lysine acetylation | 123/8552 | 169/18723 | 6.58e-13 | 2.94e-11 | 123 |
GO:004354313 | Esophagus | ESCC | protein acylation | 165/8552 | 243/18723 | 1.69e-12 | 7.14e-11 | 165 |
GO:000647313 | Esophagus | ESCC | protein acetylation | 140/8552 | 201/18723 | 4.37e-12 | 1.69e-10 | 140 |
GO:001839313 | Esophagus | ESCC | internal peptidyl-lysine acetylation | 114/8552 | 158/18723 | 1.16e-11 | 4.24e-10 | 114 |
GO:000647513 | Esophagus | ESCC | internal protein amino acid acetylation | 115/8552 | 160/18723 | 1.43e-11 | 5.08e-10 | 115 |
GO:00165735 | Esophagus | ESCC | histone acetylation | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:000640512 | Esophagus | ESCC | RNA export from nucleus | 68/8552 | 84/18723 | 2.99e-11 | 1.01e-09 | 68 |
Page: 1 2 3 4 5 6 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MCM3AP | SNV | Missense_Mutation | novel | c.2965N>C | p.Tyr989His | p.Y989H | O60318 | protein_coding | deleterious(0) | possibly_damaging(0.867) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MCM3AP | SNV | Missense_Mutation | rs771441002 | c.4319N>T | p.Ala1440Val | p.A1440V | O60318 | protein_coding | tolerated(0.21) | benign(0.01) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MCM3AP | SNV | Missense_Mutation | c.1928N>C | p.Glu643Ala | p.E643A | O60318 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-7715-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MCM3AP | SNV | Missense_Mutation | c.1082N>C | p.Lys361Thr | p.K361T | O60318 | protein_coding | deleterious(0.03) | benign(0.425) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
MCM3AP | SNV | Missense_Mutation | c.4939C>T | p.Leu1647Phe | p.L1647F | O60318 | protein_coding | tolerated(0.06) | possibly_damaging(0.796) | TCGA-CG-4304-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MCM3AP | SNV | Missense_Mutation | c.1946N>A | p.Arg649Gln | p.R649Q | O60318 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MCM3AP | SNV | Missense_Mutation | c.2068N>A | p.Glu690Lys | p.E690K | O60318 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
MCM3AP | SNV | Missense_Mutation | c.1277T>C | p.Leu426Pro | p.L426P | O60318 | protein_coding | deleterious(0.03) | benign(0.092) | TCGA-CG-4476-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MCM3AP | SNV | Missense_Mutation | c.218N>C | p.Leu73Ser | p.L73S | O60318 | protein_coding | tolerated(0.22) | benign(0) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
MCM3AP | SNV | Missense_Mutation | c.2806C>T | p.Arg936Trp | p.R936W | O60318 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-F1-6177-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |