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Gene: MAGI1 |
Gene summary for MAGI1 |
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Gene information | Species | Human | Gene symbol | MAGI1 | Gene ID | 9223 |
Gene name | membrane associated guanylate kinase, WW and PDZ domain containing 1 | |
Gene Alias | AIP-3 | |
Cytomap | 3p14.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q96QZ7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9223 | MAGI1 | CCI_2 | Human | Cervix | CC | 1.11e-11 | 9.02e-01 | 0.5249 |
9223 | MAGI1 | CCI_3 | Human | Cervix | CC | 1.39e-09 | 6.58e-01 | 0.516 |
9223 | MAGI1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.10e-11 | -4.36e-01 | 0.0155 |
9223 | MAGI1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.21e-02 | 3.12e-01 | -0.1808 |
9223 | MAGI1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.94e-21 | 7.73e-01 | -0.1954 |
9223 | MAGI1 | HTA11_411_2000001011 | Human | Colorectum | SER | 9.18e-05 | 7.49e-01 | -0.2602 |
9223 | MAGI1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.94e-05 | 2.85e-01 | -0.2196 |
9223 | MAGI1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.68e-04 | -4.77e-01 | -0.0179 |
9223 | MAGI1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.86e-04 | -4.69e-01 | 0.096 |
9223 | MAGI1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.03e-06 | -6.37e-01 | 0.0451 |
9223 | MAGI1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.39e-02 | -2.88e-01 | 0.0674 |
9223 | MAGI1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 2.38e-03 | -7.20e-01 | -0.0124 |
9223 | MAGI1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.64e-12 | -4.49e-01 | 0.294 |
9223 | MAGI1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.65e-18 | 1.05e+00 | 0.3487 |
9223 | MAGI1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.53e-04 | 4.71e-01 | 0.281 |
9223 | MAGI1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.37e-05 | -7.98e-02 | 0.3859 |
9223 | MAGI1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.48e-14 | -8.20e-01 | 0.2585 |
9223 | MAGI1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.85e-34 | -7.99e-01 | 0.3005 |
9223 | MAGI1 | A015-C-203 | Human | Colorectum | FAP | 5.62e-31 | -5.25e-01 | -0.1294 |
9223 | MAGI1 | A014-C-040 | Human | Colorectum | FAP | 2.50e-02 | -3.18e-01 | -0.1184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002240710 | Cervix | CC | regulation of cell-cell adhesion | 103/2311 | 448/18723 | 1.78e-10 | 2.87e-08 | 103 |
GO:004578510 | Cervix | CC | positive regulation of cell adhesion | 101/2311 | 437/18723 | 1.96e-10 | 3.08e-08 | 101 |
GO:00224099 | Cervix | CC | positive regulation of cell-cell adhesion | 61/2311 | 284/18723 | 9.30e-06 | 2.11e-04 | 61 |
GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
GO:00457851 | Colorectum | SER | positive regulation of cell adhesion | 93/2897 | 437/18723 | 6.78e-04 | 9.04e-03 | 93 |
GO:00457852 | Colorectum | MSS | positive regulation of cell adhesion | 110/3467 | 437/18723 | 2.94e-04 | 3.87e-03 | 110 |
GO:00457853 | Colorectum | MSI-H | positive regulation of cell adhesion | 48/1319 | 437/18723 | 1.47e-03 | 2.23e-02 | 48 |
GO:00457854 | Colorectum | FAP | positive regulation of cell adhesion | 92/2622 | 437/18723 | 3.09e-05 | 7.04e-04 | 92 |
GO:00457855 | Colorectum | CRC | positive regulation of cell adhesion | 81/2078 | 437/18723 | 2.28e-06 | 1.10e-04 | 81 |
GO:0022407 | Colorectum | CRC | regulation of cell-cell adhesion | 67/2078 | 448/18723 | 6.86e-03 | 4.81e-02 | 67 |
GO:004578516 | Endometrium | AEH | positive regulation of cell adhesion | 96/2100 | 437/18723 | 5.50e-11 | 7.18e-09 | 96 |
GO:002240714 | Endometrium | AEH | regulation of cell-cell adhesion | 79/2100 | 448/18723 | 2.90e-05 | 5.40e-04 | 79 |
GO:002240910 | Endometrium | AEH | positive regulation of cell-cell adhesion | 54/2100 | 284/18723 | 6.94e-05 | 1.07e-03 | 54 |
GO:004578517 | Endometrium | EEC | positive regulation of cell adhesion | 98/2168 | 437/18723 | 6.15e-11 | 8.38e-09 | 98 |
GO:002240715 | Endometrium | EEC | regulation of cell-cell adhesion | 84/2168 | 448/18723 | 4.98e-06 | 1.24e-04 | 84 |
GO:002240914 | Endometrium | EEC | positive regulation of cell-cell adhesion | 56/2168 | 284/18723 | 4.36e-05 | 7.15e-04 | 56 |
GO:00457857 | Liver | Cirrhotic | positive regulation of cell adhesion | 141/4634 | 437/18723 | 2.05e-04 | 1.89e-03 | 141 |
GO:004578512 | Liver | HCC | positive regulation of cell adhesion | 215/7958 | 437/18723 | 2.53e-03 | 1.22e-02 | 215 |
GO:00224096 | Liver | Cyst | positive regulation of cell-cell adhesion | 19/496 | 284/18723 | 2.19e-04 | 8.05e-03 | 19 |
GO:004578522 | Liver | Cyst | positive regulation of cell adhesion | 25/496 | 437/18723 | 2.79e-04 | 9.40e-03 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0453020 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0401512 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa051657 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa04530110 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0401513 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0516512 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa04530 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa04015 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa045301 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa040151 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa045302 | Colorectum | SER | Tight junction | 59/1580 | 169/8465 | 3.24e-07 | 5.98e-06 | 4.34e-06 | 59 |
hsa040152 | Colorectum | SER | Rap1 signaling pathway | 54/1580 | 210/8465 | 6.55e-03 | 3.68e-02 | 2.67e-02 | 54 |
hsa045303 | Colorectum | SER | Tight junction | 59/1580 | 169/8465 | 3.24e-07 | 5.98e-06 | 4.34e-06 | 59 |
hsa040153 | Colorectum | SER | Rap1 signaling pathway | 54/1580 | 210/8465 | 6.55e-03 | 3.68e-02 | 2.67e-02 | 54 |
hsa045304 | Colorectum | MSS | Tight junction | 66/1875 | 169/8465 | 4.10e-07 | 6.25e-06 | 3.83e-06 | 66 |
hsa040154 | Colorectum | MSS | Rap1 signaling pathway | 66/1875 | 210/8465 | 1.03e-03 | 5.94e-03 | 3.64e-03 | 66 |
hsa045305 | Colorectum | MSS | Tight junction | 66/1875 | 169/8465 | 4.10e-07 | 6.25e-06 | 3.83e-06 | 66 |
hsa040155 | Colorectum | MSS | Rap1 signaling pathway | 66/1875 | 210/8465 | 1.03e-03 | 5.94e-03 | 3.64e-03 | 66 |
hsa045306 | Colorectum | MSI-H | Tight junction | 31/797 | 169/8465 | 2.08e-04 | 2.80e-03 | 2.35e-03 | 31 |
hsa045307 | Colorectum | MSI-H | Tight junction | 31/797 | 169/8465 | 2.08e-04 | 2.80e-03 | 2.35e-03 | 31 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAGI1 | SNV | Missense_Mutation | novel | c.422N>T | p.Ala141Val | p.A141V | Q96QZ7 | protein_coding | deleterious(0.01) | benign(0.101) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
MAGI1 | SNV | Missense_Mutation | c.1786A>C | p.Ser596Arg | p.S596R | Q96QZ7 | protein_coding | tolerated(0.42) | possibly_damaging(0.446) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MAGI1 | SNV | Missense_Mutation | c.304G>T | p.Val102Phe | p.V102F | Q96QZ7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MAGI1 | SNV | Missense_Mutation | rs756694536 | c.1454N>T | p.Thr485Met | p.T485M | Q96QZ7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAGI1 | SNV | Missense_Mutation | rs760749180 | c.4222G>A | p.Glu1408Lys | p.E1408K | Q96QZ7 | protein_coding | deleterious_low_confidence(0.01) | benign(0.288) | TCGA-BR-8081-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAGI1 | SNV | Missense_Mutation | c.17N>T | p.Gln6Leu | p.Q6L | Q96QZ7 | protein_coding | tolerated(0.16) | benign(0.011) | TCGA-CD-5813-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
MAGI1 | SNV | Missense_Mutation | c.803N>C | p.Leu268Ser | p.L268S | Q96QZ7 | protein_coding | tolerated(0.43) | benign(0.031) | TCGA-CG-4305-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
MAGI1 | SNV | Missense_Mutation | rs779881861 | c.1426N>T | p.Arg476Trp | p.R476W | Q96QZ7 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
MAGI1 | SNV | Missense_Mutation | novel | c.4061N>T | p.Arg1354Met | p.R1354M | Q96QZ7 | protein_coding | deleterious(0.03) | benign(0.413) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
MAGI1 | SNV | Missense_Mutation | rs779070587 | c.3830N>G | p.Asn1277Ser | p.N1277S | Q96QZ7 | protein_coding | tolerated(0.34) | benign(0.005) | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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