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Gene: LRP6 |
Gene summary for LRP6 |
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Gene information | Species | Human | Gene symbol | LRP6 | Gene ID | 4040 |
Gene name | LDL receptor related protein 6 | |
Gene Alias | ADCAD2 | |
Cytomap | 12p13.2 | |
Gene Type | protein-coding | GO ID | GO:0001756 | UniProtAcc | O75581 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4040 | LRP6 | CCI_2 | Human | Cervix | CC | 1.37e-08 | 1.05e+00 | 0.5249 |
4040 | LRP6 | CCI_3 | Human | Cervix | CC | 3.41e-20 | 1.04e+00 | 0.516 |
4040 | LRP6 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.04e-14 | -5.65e-01 | 0.0155 |
4040 | LRP6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.18e-02 | -4.27e-01 | -0.1808 |
4040 | LRP6 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.90e-06 | -4.88e-01 | -0.1088 |
4040 | LRP6 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.17e-02 | -3.09e-01 | -0.1954 |
4040 | LRP6 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.93e-15 | -4.78e-01 | -0.1464 |
4040 | LRP6 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.56e-11 | -4.49e-01 | -0.1001 |
4040 | LRP6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.48e-04 | -4.37e-01 | -0.059 |
4040 | LRP6 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.20e-07 | -4.89e-01 | 0.096 |
4040 | LRP6 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.68e-03 | -4.71e-01 | 0.0338 |
4040 | LRP6 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.33e-14 | -5.03e-01 | 0.0674 |
4040 | LRP6 | HTA11_6818_2000001011 | Human | Colorectum | AD | 4.19e-03 | -5.83e-01 | 0.0112 |
4040 | LRP6 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.50e-07 | -3.46e-01 | 0.294 |
4040 | LRP6 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.24e-05 | -3.88e-01 | 0.3859 |
4040 | LRP6 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.29e-14 | -4.79e-01 | 0.3005 |
4040 | LRP6 | A015-C-203 | Human | Colorectum | FAP | 4.07e-20 | -2.09e-01 | -0.1294 |
4040 | LRP6 | A015-C-204 | Human | Colorectum | FAP | 2.58e-03 | -2.02e-01 | -0.0228 |
4040 | LRP6 | A002-C-201 | Human | Colorectum | FAP | 7.11e-09 | -2.55e-01 | 0.0324 |
4040 | LRP6 | A001-C-119 | Human | Colorectum | FAP | 1.23e-03 | -2.91e-01 | -0.1557 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007265910 | Cervix | CC | protein localization to plasma membrane | 73/2311 | 284/18723 | 4.95e-10 | 6.73e-08 | 73 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:19907788 | Cervix | CC | protein localization to cell periphery | 78/2311 | 333/18723 | 1.22e-08 | 9.73e-07 | 78 |
GO:00600707 | Cervix | CC | canonical Wnt signaling pathway | 66/2311 | 303/18723 | 2.47e-06 | 7.35e-05 | 66 |
GO:00719007 | Cervix | CC | regulation of protein serine/threonine kinase activity | 75/2311 | 359/18723 | 2.76e-06 | 8.02e-05 | 75 |
GO:005134810 | Cervix | CC | negative regulation of transferase activity | 60/2311 | 268/18723 | 2.77e-06 | 8.02e-05 | 60 |
GO:004593610 | Cervix | CC | negative regulation of phosphate metabolic process | 88/2311 | 441/18723 | 2.92e-06 | 8.27e-05 | 88 |
GO:001056310 | Cervix | CC | negative regulation of phosphorus metabolic process | 88/2311 | 442/18723 | 3.21e-06 | 8.77e-05 | 88 |
GO:00510904 | Cervix | CC | regulation of DNA-binding transcription factor activity | 87/2311 | 440/18723 | 4.85e-06 | 1.22e-04 | 87 |
GO:00457876 | Cervix | CC | positive regulation of cell cycle | 66/2311 | 313/18723 | 7.78e-06 | 1.81e-04 | 66 |
GO:004232610 | Cervix | CC | negative regulation of phosphorylation | 77/2311 | 385/18723 | 1.09e-05 | 2.38e-04 | 77 |
GO:00309019 | Cervix | CC | midbrain development | 26/2311 | 90/18723 | 2.12e-05 | 3.82e-04 | 26 |
GO:000193310 | Cervix | CC | negative regulation of protein phosphorylation | 69/2311 | 342/18723 | 2.29e-05 | 4.01e-04 | 69 |
GO:00068987 | Cervix | CC | receptor-mediated endocytosis | 53/2311 | 244/18723 | 2.52e-05 | 4.29e-04 | 53 |
GO:00488634 | Cervix | CC | stem cell differentiation | 46/2311 | 206/18723 | 4.11e-05 | 6.36e-04 | 46 |
GO:000646910 | Cervix | CC | negative regulation of protein kinase activity | 47/2311 | 212/18723 | 4.13e-05 | 6.36e-04 | 47 |
GO:00336739 | Cervix | CC | negative regulation of kinase activity | 50/2311 | 237/18723 | 9.22e-05 | 1.21e-03 | 50 |
GO:00434349 | Cervix | CC | response to peptide hormone | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
GO:00510915 | Cervix | CC | positive regulation of DNA-binding transcription factor activity | 51/2311 | 260/18723 | 5.05e-04 | 4.92e-03 | 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501018 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0502218 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa043109 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0522510 | Cervix | CC | Hepatocellular carcinoma | 40/1267 | 168/8465 | 1.52e-03 | 6.39e-03 | 3.78e-03 | 40 |
hsa0492812 | Cervix | CC | Parathyroid hormone synthesis, secretion and action | 27/1267 | 106/8465 | 3.12e-03 | 1.19e-02 | 7.03e-03 | 27 |
hsa05224 | Cervix | CC | Breast cancer | 32/1267 | 147/8465 | 1.66e-02 | 4.88e-02 | 2.88e-02 | 32 |
hsa0501019 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0502219 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa0431012 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0522513 | Cervix | CC | Hepatocellular carcinoma | 40/1267 | 168/8465 | 1.52e-03 | 6.39e-03 | 3.78e-03 | 40 |
hsa0492813 | Cervix | CC | Parathyroid hormone synthesis, secretion and action | 27/1267 | 106/8465 | 3.12e-03 | 1.19e-02 | 7.03e-03 | 27 |
hsa052241 | Cervix | CC | Breast cancer | 32/1267 | 147/8465 | 1.66e-02 | 4.88e-02 | 2.88e-02 | 32 |
hsa05010 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa05022 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa05225 | Colorectum | AD | Hepatocellular carcinoma | 59/2092 | 168/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 59 |
hsa04928 | Colorectum | AD | Parathyroid hormone synthesis, secretion and action | 38/2092 | 106/8465 | 6.60e-03 | 2.77e-02 | 1.76e-02 | 38 |
hsa04310 | Colorectum | AD | Wnt signaling pathway | 56/2092 | 171/8465 | 1.03e-02 | 3.93e-02 | 2.51e-02 | 56 |
hsa050101 | Colorectum | AD | Alzheimer disease | 174/2092 | 384/8465 | 1.82e-19 | 9.26e-18 | 5.91e-18 | 174 |
hsa050221 | Colorectum | AD | Pathways of neurodegeneration - multiple diseases | 201/2092 | 476/8465 | 4.54e-18 | 1.27e-16 | 8.09e-17 | 201 |
hsa052251 | Colorectum | AD | Hepatocellular carcinoma | 59/2092 | 168/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
WNT2B | FZD6_LRP6 | WNT2B_FZD6_LRP6 | WNT | Cervix | CC |
WNT9A | FZD6_LRP6 | WNT9A_FZD6_LRP6 | WNT | Cervix | CC |
WNT2 | FZD4_LRP6 | WNT2_FZD4_LRP6 | WNT | Endometrium | ADJ |
WNT2 | FZD6_LRP6 | WNT2_FZD6_LRP6 | WNT | Endometrium | ADJ |
WNT4 | FZD4_LRP6 | WNT4_FZD4_LRP6 | WNT | Endometrium | ADJ |
WNT4 | FZD6_LRP6 | WNT4_FZD6_LRP6 | WNT | Endometrium | ADJ |
WNT2 | FZD4_LRP6 | WNT2_FZD4_LRP6 | WNT | Endometrium | AEH |
WNT2B | FZD4_LRP6 | WNT2B_FZD4_LRP6 | WNT | Endometrium | AEH |
WNT4 | FZD4_LRP6 | WNT4_FZD4_LRP6 | WNT | Endometrium | AEH |
WNT2 | FZD4_LRP6 | WNT2_FZD4_LRP6 | WNT | Endometrium | EEC |
WNT2 | FZD6_LRP6 | WNT2_FZD6_LRP6 | WNT | Endometrium | EEC |
WNT2B | FZD4_LRP6 | WNT2B_FZD4_LRP6 | WNT | Endometrium | EEC |
WNT2B | FZD6_LRP6 | WNT2B_FZD6_LRP6 | WNT | Endometrium | EEC |
WNT10A | FZD10_LRP6 | WNT10A_FZD10_LRP6 | WNT | Esophagus | ESCC |
WNT10A | FZD3_LRP6 | WNT10A_FZD3_LRP6 | WNT | Esophagus | ESCC |
WNT10A | FZD4_LRP6 | WNT10A_FZD4_LRP6 | WNT | Esophagus | ESCC |
WNT10A | FZD5_LRP6 | WNT10A_FZD5_LRP6 | WNT | Esophagus | ESCC |
WNT10A | FZD6_LRP6 | WNT10A_FZD6_LRP6 | WNT | Esophagus | ESCC |
WNT10A | FZD8_LRP6 | WNT10A_FZD8_LRP6 | WNT | Esophagus | ESCC |
WNT10B | FZD10_LRP6 | WNT10B_FZD10_LRP6 | WNT | Esophagus | ESCC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRP6 | deletion | Frame_Shift_Del | novel | c.4838_4842delNNNNN | p.Ser1613TrpfsTer15 | p.S1613Wfs*15 | O75581 | protein_coding | TCGA-D7-A6EZ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | ||
LRP6 | SNV | Missense_Mutation | novel | c.4462N>G | p.Pro1488Ala | p.P1488A | O75581 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-EM-A3O3-01 | Thyroid | thyroid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
LRP6 | insertion | In_Frame_Ins | novel | c.1023_1024insTGTCCAATAAAG | p.Arg341_Ile342insCysProIleLys | p.R341_I342insCPIK | O75581 | protein_coding | TCGA-BJ-A45F-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
LRP6 | insertion | Nonsense_Mutation | novel | c.4459_4460insACTTTCAATAAATA | p.Pro1487HisfsTer4 | p.P1487Hfs*4 | O75581 | protein_coding | TCGA-EM-A3O3-01 | Thyroid | thyroid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
LRP6 | insertion | Frame_Shift_Ins | novel | c.1605_1606insGC | p.Phe536AlafsTer33 | p.F536Afs*33 | O75581 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
LRP6 | insertion | In_Frame_Ins | novel | c.1604_1605insTTCTAAGAA | p.Ile535_Phe536insSerLysLys | p.I535_F536insSKK | O75581 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
LRP6 | insertion | Frame_Shift_Ins | novel | c.852_853insAA | p.Pro285AsnfsTer15 | p.P285Nfs*15 | O75581 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
LRP6 | insertion | Frame_Shift_Ins | novel | c.851_852insACACTCCTATTCTA | p.Asn284LysfsTer20 | p.N284Kfs*20 | O75581 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
LRP6 | insertion | Nonsense_Mutation | novel | c.510_511insATTTCTTAATAAAATTAGGCTTTGTAATGTA | p.Ser171IlefsTer3 | p.S171Ifs*3 | O75581 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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