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Gene: EXPH5 |
Gene summary for EXPH5 |
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Gene information | Species | Human | Gene symbol | EXPH5 | Gene ID | 23086 |
Gene name | exophilin 5 | |
Gene Alias | SLAC2-B | |
Cytomap | 11q22.3 | |
Gene Type | protein-coding | GO ID | GO:0002064 | UniProtAcc | Q149M6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23086 | EXPH5 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.08e-29 | 1.10e+00 | -0.1954 |
23086 | EXPH5 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.94e-07 | 1.15e+00 | -0.2602 |
23086 | EXPH5 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.01e-03 | 4.24e-01 | -0.1001 |
23086 | EXPH5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.62e-15 | -4.93e-01 | 0.3005 |
23086 | EXPH5 | A015-C-203 | Human | Colorectum | FAP | 1.73e-16 | 2.39e-02 | -0.1294 |
23086 | EXPH5 | A002-C-201 | Human | Colorectum | FAP | 2.35e-05 | -1.05e-01 | 0.0324 |
23086 | EXPH5 | A001-C-119 | Human | Colorectum | FAP | 1.52e-03 | 1.24e-01 | -0.1557 |
23086 | EXPH5 | A001-C-108 | Human | Colorectum | FAP | 2.04e-11 | 3.03e-01 | -0.0272 |
23086 | EXPH5 | A002-C-205 | Human | Colorectum | FAP | 3.85e-14 | 8.96e-02 | -0.1236 |
23086 | EXPH5 | A015-C-006 | Human | Colorectum | FAP | 5.49e-07 | -2.35e-01 | -0.0994 |
23086 | EXPH5 | A015-C-106 | Human | Colorectum | FAP | 2.37e-06 | 4.44e-02 | -0.0511 |
23086 | EXPH5 | A002-C-114 | Human | Colorectum | FAP | 8.54e-09 | -1.08e-01 | -0.1561 |
23086 | EXPH5 | A015-C-104 | Human | Colorectum | FAP | 2.53e-17 | 2.14e-02 | -0.1899 |
23086 | EXPH5 | A001-C-014 | Human | Colorectum | FAP | 5.17e-09 | 1.24e-01 | 0.0135 |
23086 | EXPH5 | A002-C-016 | Human | Colorectum | FAP | 1.21e-11 | -1.10e-01 | 0.0521 |
23086 | EXPH5 | A015-C-002 | Human | Colorectum | FAP | 9.82e-05 | -7.77e-02 | -0.0763 |
23086 | EXPH5 | A001-C-203 | Human | Colorectum | FAP | 8.10e-03 | 7.38e-02 | -0.0481 |
23086 | EXPH5 | A002-C-116 | Human | Colorectum | FAP | 4.91e-22 | -1.52e-01 | -0.0452 |
23086 | EXPH5 | A014-C-008 | Human | Colorectum | FAP | 1.95e-10 | 2.33e-01 | -0.191 |
23086 | EXPH5 | A018-E-020 | Human | Colorectum | FAP | 1.14e-10 | 2.93e-02 | -0.2034 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002064 | Colorectum | AD | epithelial cell development | 89/3918 | 220/18723 | 2.98e-11 | 3.52e-09 | 89 |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
GO:0071985 | Colorectum | AD | multivesicular body sorting pathway | 19/3918 | 37/18723 | 4.08e-05 | 7.26e-04 | 19 |
GO:0050708 | Colorectum | AD | regulation of protein secretion | 83/3918 | 268/18723 | 6.59e-05 | 1.07e-03 | 83 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0045921 | Colorectum | AD | positive regulation of exocytosis | 33/3918 | 86/18723 | 1.58e-04 | 2.20e-03 | 33 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:0017157 | Colorectum | AD | regulation of exocytosis | 59/3918 | 202/18723 | 3.20e-03 | 2.36e-02 | 59 |
GO:0050714 | Colorectum | AD | positive regulation of protein secretion | 42/3918 | 137/18723 | 4.64e-03 | 3.16e-02 | 42 |
GO:0009913 | Colorectum | AD | epidermal cell differentiation | 58/3918 | 202/18723 | 5.16e-03 | 3.42e-02 | 58 |
GO:0008544 | Colorectum | AD | epidermis development | 87/3918 | 324/18723 | 5.99e-03 | 3.76e-02 | 87 |
GO:19049511 | Colorectum | SER | positive regulation of establishment of protein localization | 91/2897 | 319/18723 | 1.69e-09 | 1.68e-07 | 91 |
GO:00512221 | Colorectum | SER | positive regulation of protein transport | 85/2897 | 303/18723 | 1.36e-08 | 1.05e-06 | 85 |
GO:00020641 | Colorectum | SER | epithelial cell development | 64/2897 | 220/18723 | 1.96e-07 | 1.10e-05 | 64 |
GO:00719851 | Colorectum | SER | multivesicular body sorting pathway | 17/2897 | 37/18723 | 1.12e-05 | 3.60e-04 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EXPH5 | SNV | Missense_Mutation | c.5915N>A | p.Thr1972Lys | p.T1972K | Q8NEV8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-L9-A443-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EXPH5 | SNV | Missense_Mutation | c.4349N>A | p.Ser1450Asn | p.S1450N | Q8NEV8 | protein_coding | tolerated(0.2) | benign(0.042) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EXPH5 | SNV | Missense_Mutation | novel | c.494N>T | p.Gln165Leu | p.Q165L | Q8NEV8 | protein_coding | deleterious(0.04) | benign(0.125) | TCGA-MP-A4T4-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EXPH5 | SNV | Missense_Mutation | novel | c.3050N>G | p.Thr1017Arg | p.T1017R | Q8NEV8 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-NJ-A4YG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EXPH5 | SNV | Missense_Mutation | c.3665G>T | p.Arg1222Leu | p.R1222L | Q8NEV8 | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-22-4595-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | alimta | PD | |
EXPH5 | SNV | Missense_Mutation | novel | c.74T>G | p.Leu25Arg | p.L25R | Q8NEV8 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-22-4609-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EXPH5 | SNV | Missense_Mutation | c.3257N>T | p.Ser1086Leu | p.S1086L | Q8NEV8 | protein_coding | tolerated(0.07) | benign(0.105) | TCGA-22-5474-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EXPH5 | SNV | Missense_Mutation | c.4653N>C | p.Glu1551Asp | p.E1551D | Q8NEV8 | protein_coding | tolerated(0.2) | benign(0.036) | TCGA-33-6737-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemcitabine | PD | |
EXPH5 | SNV | Missense_Mutation | novel | c.651N>G | p.Ser217Arg | p.S217R | Q8NEV8 | protein_coding | tolerated(0.05) | benign(0.209) | TCGA-34-2605-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD |
EXPH5 | SNV | Missense_Mutation | novel | c.3434N>T | p.Ser1145Leu | p.S1145L | Q8NEV8 | protein_coding | tolerated(0.33) | benign(0.315) | TCGA-34-5241-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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