![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ESPL1 |
Gene summary for ESPL1 |
![]() |
Gene information | Species | Human | Gene symbol | ESPL1 | Gene ID | 9700 |
Gene name | extra spindle pole bodies like 1, separase | |
Gene Alias | ESP1 | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q14674 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9700 | ESPL1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.47e-03 | 1.09e-01 | 0.0155 |
9700 | ESPL1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.87e-02 | 1.40e-01 | -0.1808 |
9700 | ESPL1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-02 | 1.89e-01 | 0.0216 |
9700 | ESPL1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.27e-05 | 2.06e-01 | -0.0811 |
9700 | ESPL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.18e-10 | 2.28e-01 | -0.1954 |
9700 | ESPL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.52e-18 | 4.79e-01 | -0.1464 |
9700 | ESPL1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.45e-06 | 1.72e-01 | -0.059 |
9700 | ESPL1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.31e-08 | 4.40e-01 | -0.1706 |
9700 | ESPL1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-03 | 2.77e-01 | -0.1462 |
9700 | ESPL1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.44e-03 | 2.11e-01 | -0.0842 |
9700 | ESPL1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.26e-04 | 1.65e-01 | 0.281 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:0000910 | Colorectum | AD | cytokinesis | 59/3918 | 173/18723 | 3.74e-05 | 6.75e-04 | 59 |
GO:0061640 | Colorectum | AD | cytoskeleton-dependent cytokinesis | 37/3918 | 100/18723 | 1.58e-04 | 2.20e-03 | 37 |
GO:0033044 | Colorectum | AD | regulation of chromosome organization | 60/3918 | 187/18723 | 2.25e-04 | 2.94e-03 | 60 |
GO:0007063 | Colorectum | AD | regulation of sister chromatid cohesion | 12/3918 | 21/18723 | 3.02e-04 | 3.62e-03 | 12 |
GO:0007051 | Colorectum | AD | spindle organization | 58/3918 | 184/18723 | 4.71e-04 | 5.20e-03 | 58 |
GO:1902850 | Colorectum | AD | microtubule cytoskeleton organization involved in mitosis | 48/3918 | 147/18723 | 5.87e-04 | 6.21e-03 | 48 |
GO:0007062 | Colorectum | AD | sister chromatid cohesion | 23/3918 | 62/18723 | 2.51e-03 | 1.92e-02 | 23 |
GO:0000281 | Colorectum | AD | mitotic cytokinesis | 25/3918 | 71/18723 | 3.77e-03 | 2.65e-02 | 25 |
GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
GO:0045787 | Colorectum | AD | positive regulation of cell cycle | 85/3918 | 313/18723 | 4.76e-03 | 3.22e-02 | 85 |
GO:0045842 | Colorectum | AD | positive regulation of mitotic metaphase/anaphase transition | 8/3918 | 15/18723 | 5.67e-03 | 3.64e-02 | 8 |
GO:1901970 | Colorectum | AD | positive regulation of mitotic sister chromatid separation | 8/3918 | 15/18723 | 5.67e-03 | 3.64e-02 | 8 |
GO:1905820 | Colorectum | AD | positive regulation of chromosome separation | 9/3918 | 18/18723 | 5.82e-03 | 3.67e-02 | 9 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
GO:0045931 | Colorectum | AD | positive regulation of mitotic cell cycle | 37/3918 | 121/18723 | 7.88e-03 | 4.73e-02 | 37 |
GO:00516561 | Colorectum | SER | establishment of organelle localization | 100/2897 | 390/18723 | 1.11e-07 | 6.79e-06 | 100 |
GO:00106391 | Colorectum | SER | negative regulation of organelle organization | 90/2897 | 348/18723 | 3.14e-07 | 1.69e-05 | 90 |
GO:00009101 | Colorectum | SER | cytokinesis | 45/2897 | 173/18723 | 2.28e-04 | 3.93e-03 | 45 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05166 | Colorectum | AD | Human T-cell leukemia virus 1 infection | 72/2092 | 222/8465 | 5.24e-03 | 2.44e-02 | 1.55e-02 | 72 |
hsa051661 | Colorectum | AD | Human T-cell leukemia virus 1 infection | 72/2092 | 222/8465 | 5.24e-03 | 2.44e-02 | 1.55e-02 | 72 |
hsa051662 | Colorectum | MSS | Human T-cell leukemia virus 1 infection | 68/1875 | 222/8465 | 1.84e-03 | 9.61e-03 | 5.89e-03 | 68 |
hsa051663 | Colorectum | MSS | Human T-cell leukemia virus 1 infection | 68/1875 | 222/8465 | 1.84e-03 | 9.61e-03 | 5.89e-03 | 68 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ESPL1 | SNV | Missense_Mutation | c.2230T>C | p.Ser744Pro | p.S744P | Q14674 | protein_coding | deleterious(0.01) | probably_damaging(0.915) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ESPL1 | SNV | Missense_Mutation | c.3260N>G | p.Gln1087Arg | p.Q1087R | Q14674 | protein_coding | tolerated(0.7) | benign(0) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ESPL1 | SNV | Missense_Mutation | c.6049N>T | p.Arg2017Trp | p.R2017W | Q14674 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CG-5726-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ESPL1 | SNV | Missense_Mutation | c.3035T>C | p.Leu1012Ser | p.L1012S | Q14674 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD | |
ESPL1 | SNV | Missense_Mutation | c.4574N>T | p.Glu1525Val | p.E1525V | Q14674 | protein_coding | tolerated(0.08) | benign(0.007) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ESPL1 | SNV | Missense_Mutation | novel | c.1960N>T | p.Arg654Trp | p.R654W | Q14674 | protein_coding | deleterious(0) | benign(0.332) | TCGA-RD-A8NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ESPL1 | SNV | Missense_Mutation | c.5374N>A | p.Ala1792Thr | p.A1792T | Q14674 | protein_coding | tolerated(0.6) | benign(0) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | ||
ESPL1 | SNV | Missense_Mutation | novel | c.5999N>G | p.Tyr2000Cys | p.Y2000C | Q14674 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VQ-A923-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ESPL1 | SNV | Missense_Mutation | novel | c.104C>T | p.Ala35Val | p.A35V | Q14674 | protein_coding | tolerated(0.21) | benign(0.015) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ESPL1 | SNV | Missense_Mutation | novel | c.3874T>C | p.Trp1292Arg | p.W1292R | Q14674 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |