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Gene: EPHA6 |
Gene summary for EPHA6 |
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Gene information | Species | Human | Gene symbol | EPHA6 | Gene ID | 285220 |
Gene name | EPH receptor A6 | |
Gene Alias | EHK-2 | |
Cytomap | 3q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A0B4J1T8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285220 | EPHA6 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.92e-13 | 2.90e-01 | 0.0155 |
285220 | EPHA6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.19e-20 | 5.56e-01 | -0.1808 |
285220 | EPHA6 | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.78e-07 | 5.37e-01 | 0.0216 |
285220 | EPHA6 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.54e-29 | 8.21e-01 | -0.0811 |
285220 | EPHA6 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.06e-19 | 6.48e-01 | -0.1088 |
285220 | EPHA6 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.47e-26 | 5.04e-01 | -0.1954 |
285220 | EPHA6 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.02e-04 | 4.13e-01 | -0.2602 |
285220 | EPHA6 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.02e-09 | 4.82e-01 | -0.2196 |
285220 | EPHA6 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.33e-17 | 4.86e-01 | -0.1207 |
285220 | EPHA6 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.84e-09 | 4.28e-01 | -0.1526 |
285220 | EPHA6 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.81e-16 | 3.96e-01 | -0.1464 |
285220 | EPHA6 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.01e-06 | 2.45e-01 | -0.1001 |
285220 | EPHA6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.05e-14 | 3.57e-01 | -0.059 |
285220 | EPHA6 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.85e-08 | 4.18e-01 | -0.1706 |
285220 | EPHA6 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.18e-04 | 2.50e-01 | -0.0842 |
285220 | EPHA6 | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.16e-02 | 3.47e-01 | 0.0451 |
285220 | EPHA6 | HTA11_10623_2000001011 | Human | Colorectum | AD | 7.94e-17 | 6.53e-01 | -0.0177 |
285220 | EPHA6 | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.97e-04 | 3.04e-01 | 0.0171 |
285220 | EPHA6 | HTA11_6818_2000001011 | Human | Colorectum | AD | 5.79e-30 | 1.55e+00 | 0.0112 |
285220 | EPHA6 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.05e-02 | 3.49e-01 | -0.0124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
GO:0033674 | Colorectum | AD | positive regulation of kinase activity | 131/3918 | 467/18723 | 1.28e-04 | 1.85e-03 | 131 |
GO:0007411 | Colorectum | AD | axon guidance | 64/3918 | 227/18723 | 5.41e-03 | 3.55e-02 | 64 |
GO:0097485 | Colorectum | AD | neuron projection guidance | 64/3918 | 228/18723 | 6.02e-03 | 3.78e-02 | 64 |
GO:00336741 | Colorectum | SER | positive regulation of kinase activity | 95/2897 | 467/18723 | 2.62e-03 | 2.41e-02 | 95 |
GO:00074111 | Colorectum | SER | axon guidance | 51/2897 | 227/18723 | 3.29e-03 | 2.82e-02 | 51 |
GO:00974851 | Colorectum | SER | neuron projection guidance | 51/2897 | 228/18723 | 3.61e-03 | 3.03e-02 | 51 |
GO:00615641 | Colorectum | SER | axon development | 94/2897 | 467/18723 | 3.78e-03 | 3.13e-02 | 94 |
GO:00074091 | Colorectum | SER | axonogenesis | 84/2897 | 418/18723 | 6.20e-03 | 4.49e-02 | 84 |
GO:00336742 | Colorectum | MSS | positive regulation of kinase activity | 122/3467 | 467/18723 | 2.50e-05 | 5.21e-04 | 122 |
GO:00074092 | Colorectum | MSS | axonogenesis | 105/3467 | 418/18723 | 4.32e-04 | 5.23e-03 | 105 |
GO:00615642 | Colorectum | MSS | axon development | 115/3467 | 467/18723 | 5.33e-04 | 6.00e-03 | 115 |
GO:0048013 | Colorectum | MSS | ephrin receptor signaling pathway | 17/3467 | 51/18723 | 8.28e-03 | 4.99e-02 | 17 |
GO:00336743 | Colorectum | MSI-H | positive regulation of kinase activity | 53/1319 | 467/18723 | 3.99e-04 | 8.98e-03 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04360 | Colorectum | AD | Axon guidance | 61/2092 | 182/8465 | 4.36e-03 | 2.17e-02 | 1.38e-02 | 61 |
hsa043601 | Colorectum | AD | Axon guidance | 61/2092 | 182/8465 | 4.36e-03 | 2.17e-02 | 1.38e-02 | 61 |
hsa043602 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa043603 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EPHA6 | SNV | Missense_Mutation | novel | c.1321C>T | p.Leu441Phe | p.L441F | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EPHA6 | SNV | Missense_Mutation | c.297N>T | p.Glu99Asp | p.E99D | protein_coding | tolerated_low_confidence(0.12) | benign(0) | TCGA-18-3406-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
EPHA6 | SNV | Missense_Mutation | rs753848380 | c.1969N>A | p.Val657Ile | p.V657I | protein_coding | tolerated(0.25) | benign(0.031) | TCGA-18-3417-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
EPHA6 | SNV | Missense_Mutation | novel | c.3055N>T | p.Asp1019Tyr | p.D1019Y | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-21-A5DI-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
EPHA6 | SNV | Missense_Mutation | c.115N>A | p.Gly39Arg | p.G39R | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.602) | TCGA-22-5480-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | gemzar | PD | ||
EPHA6 | SNV | Missense_Mutation | c.2972N>T | p.Ala991Val | p.A991V | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-33-4532-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
EPHA6 | SNV | Missense_Mutation | c.1219N>A | p.Glu407Lys | p.E407K | protein_coding | tolerated(0.11) | probably_damaging(0.992) | TCGA-39-5028-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
EPHA6 | SNV | Missense_Mutation | c.1763N>C | p.Arg588Thr | p.R588T | protein_coding | tolerated(0.19) | probably_damaging(0.991) | TCGA-39-5040-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD | ||
EPHA6 | SNV | Missense_Mutation | c.1382N>C | p.Val461Ala | p.V461A | protein_coding | tolerated(0.1) | probably_damaging(0.989) | TCGA-43-8116-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
EPHA6 | SNV | Missense_Mutation | novel | c.1425N>G | p.Asp475Glu | p.D475E | protein_coding | tolerated(0.31) | benign(0.054) | TCGA-43-8118-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
285220 | EPHA6 | DRUGGABLE GENOME, KINASE, TYROSINE KINASE | inhibitor | HESPERADIN | HESPERADIN | 19035792 |
285220 | EPHA6 | DRUGGABLE GENOME, KINASE, TYROSINE KINASE | inhibitor | CHEMBL24828 | VANDETANIB |
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