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Gene: DOPEY2 |
Gene summary for DOPEY2 |
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Gene information | Species | Human | Gene symbol | DOPEY2 | Gene ID | 9980 |
Gene name | DOP1 leucine zipper like protein B | |
Gene Alias | 21orf5 | |
Cytomap | 21q22.12 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9Y3R5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9980 | DOPEY2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.70e-31 | -7.05e-01 | 0.0155 |
9980 | DOPEY2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.43e-18 | -7.05e-01 | -0.1808 |
9980 | DOPEY2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.46e-04 | -7.05e-01 | 0.0216 |
9980 | DOPEY2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.22e-14 | -7.05e-01 | -0.0811 |
9980 | DOPEY2 | HTA11_78_2000001011 | Human | Colorectum | AD | 9.33e-22 | -7.05e-01 | -0.1088 |
9980 | DOPEY2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.88e-33 | -7.05e-01 | -0.1954 |
9980 | DOPEY2 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.70e-02 | -7.05e-01 | -0.2602 |
9980 | DOPEY2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.65e-03 | -7.05e-01 | -0.2196 |
9980 | DOPEY2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.41e-15 | -7.05e-01 | -0.1207 |
9980 | DOPEY2 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.06e-12 | -7.05e-01 | -0.1526 |
9980 | DOPEY2 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.45e-42 | -7.05e-01 | -0.1464 |
9980 | DOPEY2 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.22e-41 | -7.05e-01 | -0.1001 |
9980 | DOPEY2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.66e-25 | -7.05e-01 | -0.059 |
9980 | DOPEY2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.64e-05 | -7.05e-01 | -0.1706 |
9980 | DOPEY2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.77e-06 | -7.05e-01 | -0.2061 |
9980 | DOPEY2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.46e-04 | -7.05e-01 | -0.1462 |
9980 | DOPEY2 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.70e-10 | -7.05e-01 | -0.0842 |
9980 | DOPEY2 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.70e-02 | -7.05e-01 | -0.00410000000000005 |
9980 | DOPEY2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.37e-08 | -7.05e-01 | -0.0179 |
9980 | DOPEY2 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.46e-27 | -7.05e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DOPEY2 | SNV | Missense_Mutation | rs752679000 | c.3247N>A | p.Glu1083Lys | p.E1083K | Q9Y3R5 | protein_coding | tolerated(0.2) | benign(0.036) | TCGA-55-6712-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
DOPEY2 | SNV | Missense_Mutation | c.5969N>T | p.His1990Leu | p.H1990L | Q9Y3R5 | protein_coding | deleterious(0) | possibly_damaging(0.476) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
DOPEY2 | SNV | Missense_Mutation | c.1370N>T | p.Arg457Ile | p.R457I | Q9Y3R5 | protein_coding | deleterious(0) | possibly_damaging(0.713) | TCGA-55-A493-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DOPEY2 | SNV | Missense_Mutation | c.958N>G | p.Tyr320Asp | p.Y320D | Q9Y3R5 | protein_coding | tolerated(0.2) | benign(0.001) | TCGA-62-8395-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DOPEY2 | SNV | Missense_Mutation | novel | c.206A>T | p.Gln69Leu | p.Q69L | Q9Y3R5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-62-8399-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
DOPEY2 | SNV | Missense_Mutation | rs144551122 | c.3236N>T | p.Pro1079Leu | p.P1079L | Q9Y3R5 | protein_coding | tolerated(0.45) | benign(0.001) | TCGA-62-A470-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DOPEY2 | SNV | Missense_Mutation | rs753156977 | c.832N>T | p.Leu278Phe | p.L278F | Q9Y3R5 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-62-A471-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
DOPEY2 | SNV | Missense_Mutation | c.559N>T | p.Gly187Trp | p.G187W | Q9Y3R5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-69-7978-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DOPEY2 | SNV | Missense_Mutation | c.3576N>G | p.Phe1192Leu | p.F1192L | Q9Y3R5 | protein_coding | tolerated(1) | benign(0) | TCGA-69-7978-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DOPEY2 | SNV | Missense_Mutation | c.1775N>T | p.Gly592Val | p.G592V | Q9Y3R5 | protein_coding | deleterious(0.04) | probably_damaging(0.947) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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