GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003001031 | Lung | MIAC | establishment of cell polarity | 27/967 | 143/18723 | 4.16e-09 | 4.27e-06 | 27 |
GO:000716332 | Lung | MIAC | establishment or maintenance of cell polarity | 34/967 | 218/18723 | 7.70e-09 | 4.94e-06 | 34 |
GO:004308721 | Lung | MIAC | regulation of GTPase activity | 41/967 | 348/18723 | 7.39e-07 | 1.08e-04 | 41 |
GO:004578523 | Lung | MIAC | positive regulation of cell adhesion | 47/967 | 437/18723 | 1.62e-06 | 2.10e-04 | 47 |
GO:005105621 | Lung | MIAC | regulation of small GTPase mediated signal transduction | 35/967 | 302/18723 | 6.81e-06 | 6.35e-04 | 35 |
GO:004354721 | Lung | MIAC | positive regulation of GTPase activity | 31/967 | 255/18723 | 8.63e-06 | 7.38e-04 | 31 |
GO:003287831 | Lung | MIAC | regulation of establishment or maintenance of cell polarity | 8/967 | 25/18723 | 2.42e-05 | 1.53e-03 | 8 |
GO:200011431 | Lung | MIAC | regulation of establishment of cell polarity | 7/967 | 22/18723 | 8.25e-05 | 3.75e-03 | 7 |
GO:004209811 | Lung | MIAC | T cell proliferation | 23/967 | 199/18723 | 2.57e-04 | 8.45e-03 | 23 |
GO:004211011 | Lung | MIAC | T cell activation | 43/967 | 487/18723 | 4.40e-04 | 1.25e-02 | 43 |
GO:002240721 | Lung | MIAC | regulation of cell-cell adhesion | 39/967 | 448/18723 | 1.04e-03 | 2.11e-02 | 39 |
GO:002240911 | Lung | MIAC | positive regulation of cell-cell adhesion | 27/967 | 284/18723 | 1.71e-03 | 2.87e-02 | 27 |
GO:000715911 | Lung | MIAC | leukocyte cell-cell adhesion | 32/967 | 371/18723 | 3.24e-03 | 4.27e-02 | 32 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DOCK8 | SNV | Missense_Mutation | | c.1318N>A | p.Ala440Thr | p.A440T | Q8NF50 | protein_coding | tolerated(0.63) | benign(0) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
DOCK8 | SNV | Missense_Mutation | novel | c.5683N>C | p.Tyr1895His | p.Y1895H | Q8NF50 | protein_coding | deleterious(0) | possibly_damaging(0.728) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
DOCK8 | SNV | Missense_Mutation | | c.5249N>G | p.Glu1750Gly | p.E1750G | Q8NF50 | protein_coding | deleterious(0) | possibly_damaging(0.54) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DOCK8 | SNV | Missense_Mutation | novel | c.2128N>T | p.Pro710Ser | p.P710S | Q8NF50 | protein_coding | deleterious(0.01) | probably_damaging(0.941) | TCGA-QF-A5YS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
DOCK8 | deletion | Frame_Shift_Del | rs748134881 | c.3332delN | p.Phe1113LeufsTer2 | p.F1113Lfs*2 | Q8NF50 | protein_coding | | | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DOCK8 | insertion | Frame_Shift_Ins | novel | c.3331_3332insT | p.Met1114TyrfsTer4 | p.M1114Yfs*4 | Q8NF50 | protein_coding | | | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
DOCK8 | deletion | Frame_Shift_Del | rs748134881 | c.3332delN | p.Phe1113LeufsTer2 | p.F1113Lfs*2 | Q8NF50 | protein_coding | | | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DOCK8 | deletion | Frame_Shift_Del | rs748134881 | c.3332delN | p.Phe1113LeufsTer2 | p.F1113Lfs*2 | Q8NF50 | protein_coding | | | TCGA-AX-A2HG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DOCK8 | deletion | Frame_Shift_Del | rs748134881 | c.3339delT | p.Phe1113LeufsTer2 | p.F1113Lfs*2 | Q8NF50 | protein_coding | | | TCGA-B5-A0JZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
DOCK8 | deletion | Frame_Shift_Del | rs748134881 | c.3332delN | p.Phe1113LeufsTer2 | p.F1113Lfs*2 | Q8NF50 | protein_coding | | | TCGA-B5-A11U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |