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Gene: CTNNA2 |
Gene summary for CTNNA2 |
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Gene information | Species | Human | Gene symbol | CTNNA2 | Gene ID | 1496 |
Gene name | catenin alpha 2 | |
Gene Alias | CAP-R | |
Cytomap | 2p12 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | P26232 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1496 | CTNNA2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.77e-04 | 2.19e-01 | 0.0155 |
1496 | CTNNA2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.98e-04 | 2.47e-01 | -0.1808 |
1496 | CTNNA2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.53e-09 | 8.38e-01 | 0.0216 |
1496 | CTNNA2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.02e-10 | 4.99e-01 | -0.0811 |
1496 | CTNNA2 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.45e-04 | 2.16e-01 | -0.1954 |
1496 | CTNNA2 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.02e-04 | 4.69e-01 | -0.2602 |
1496 | CTNNA2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.61e-07 | 4.38e-01 | -0.1207 |
1496 | CTNNA2 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.52e-26 | 5.38e-01 | -0.1464 |
1496 | CTNNA2 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.11e-07 | 2.72e-01 | -0.1001 |
1496 | CTNNA2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.71e-13 | 8.44e-01 | -0.059 |
1496 | CTNNA2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.77e-05 | 5.09e-01 | -0.1706 |
1496 | CTNNA2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.71e-04 | 4.23e-01 | -0.2061 |
1496 | CTNNA2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 8.30e-11 | 6.37e-01 | -0.1462 |
1496 | CTNNA2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.98e-30 | 2.67e+00 | 0.0338 |
1496 | CTNNA2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.13e-29 | 1.18e+00 | 0.0674 |
1496 | CTNNA2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.72e-04 | 5.59e-01 | 0.2585 |
1496 | CTNNA2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.64e-05 | 2.56e-01 | 0.3005 |
1496 | CTNNA2 | A015-C-203 | Human | Colorectum | FAP | 1.39e-14 | 7.63e-01 | -0.1294 |
1496 | CTNNA2 | A002-C-201 | Human | Colorectum | FAP | 7.49e-06 | 5.41e-01 | 0.0324 |
1496 | CTNNA2 | A001-C-119 | Human | Colorectum | FAP | 3.06e-02 | 4.63e-01 | -0.1557 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030833 | Colorectum | AD | regulation of actin filament polymerization | 74/3918 | 172/18723 | 4.50e-11 | 5.03e-09 | 74 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:1902905 | Colorectum | AD | positive regulation of supramolecular fiber organization | 85/3918 | 209/18723 | 5.95e-11 | 6.33e-09 | 85 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0051495 | Colorectum | AD | positive regulation of cytoskeleton organization | 89/3918 | 226/18723 | 1.61e-10 | 1.56e-08 | 89 |
GO:0032273 | Colorectum | AD | positive regulation of protein polymerization | 62/3918 | 138/18723 | 1.94e-10 | 1.76e-08 | 62 |
GO:0031334 | Colorectum | AD | positive regulation of protein-containing complex assembly | 91/3918 | 237/18723 | 4.78e-10 | 3.99e-08 | 91 |
GO:0030838 | Colorectum | AD | positive regulation of actin filament polymerization | 48/3918 | 99/18723 | 9.21e-10 | 7.03e-08 | 48 |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa05213 | Colorectum | AD | Endometrial cancer | 29/2092 | 58/8465 | 2.69e-05 | 2.57e-04 | 1.64e-04 | 29 |
hsa04670 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa051001 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa052131 | Colorectum | AD | Endometrial cancer | 29/2092 | 58/8465 | 2.69e-05 | 2.57e-04 | 1.64e-04 | 29 |
hsa046701 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa051002 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
hsa045202 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa046702 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
hsa052132 | Colorectum | SER | Endometrial cancer | 20/1580 | 58/8465 | 3.05e-03 | 2.11e-02 | 1.53e-02 | 20 |
hsa051003 | Colorectum | SER | Bacterial invasion of epithelial cells | 36/1580 | 77/8465 | 1.56e-08 | 3.45e-07 | 2.50e-07 | 36 |
hsa045203 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa046703 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
hsa052133 | Colorectum | SER | Endometrial cancer | 20/1580 | 58/8465 | 3.05e-03 | 2.11e-02 | 1.53e-02 | 20 |
hsa045204 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa051004 | Colorectum | MSS | Bacterial invasion of epithelial cells | 36/1875 | 77/8465 | 1.41e-06 | 1.82e-05 | 1.11e-05 | 36 |
hsa052134 | Colorectum | MSS | Endometrial cancer | 27/1875 | 58/8465 | 3.18e-05 | 3.23e-04 | 1.98e-04 | 27 |
hsa04390 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTNNA2 | SNV | Missense_Mutation | c.1462N>G | p.Gln488Glu | p.Q488E | P26232 | protein_coding | tolerated(0.78) | benign(0.027) | TCGA-55-A493-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CTNNA2 | SNV | Missense_Mutation | c.203N>T | p.Thr68Ile | p.T68I | P26232 | protein_coding | tolerated(0.4) | benign(0.065) | TCGA-62-A46O-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CTNNA2 | SNV | Missense_Mutation | novel | c.849N>G | p.Phe283Leu | p.F283L | P26232 | protein_coding | tolerated(0.28) | benign(0.327) | TCGA-75-7025-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | PD |
CTNNA2 | SNV | Missense_Mutation | novel | c.197N>T | p.Gln66Leu | p.Q66L | P26232 | protein_coding | deleterious(0.04) | benign(0.012) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
CTNNA2 | SNV | Missense_Mutation | novel | c.2365N>A | p.Leu789Ile | p.L789I | P26232 | protein_coding | tolerated(0.11) | probably_damaging(0.951) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
CTNNA2 | SNV | Missense_Mutation | novel | c.580N>A | p.Gln194Lys | p.Q194K | P26232 | protein_coding | deleterious(0.02) | probably_damaging(0.959) | TCGA-78-8640-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CTNNA2 | SNV | Missense_Mutation | c.820N>C | p.Gly274Arg | p.G274R | P26232 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
CTNNA2 | SNV | Missense_Mutation | novel | c.1681N>C | p.Tyr561His | p.Y561H | P26232 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CTNNA2 | SNV | Missense_Mutation | novel | c.41C>A | p.Pro14His | p.P14H | P26232 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CTNNA2 | SNV | Missense_Mutation | c.899N>T | p.Arg300Leu | p.R300L | P26232 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1496 | CTNNA2 | NA | Tumor necrosis factor alpha (TNF-alpha) inhibitors | 27670765 |
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