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Gene: CASZ1 |
Gene summary for CASZ1 |
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Gene information | Species | Human | Gene symbol | CASZ1 | Gene ID | 54897 |
Gene name | castor zinc finger 1 | |
Gene Alias | CAS11 | |
Cytomap | 1p36.22 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KRV8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54897 | CASZ1 | CCI_1 | Human | Cervix | CC | 4.93e-05 | 6.29e-01 | 0.528 |
54897 | CASZ1 | CCI_2 | Human | Cervix | CC | 5.09e-04 | 8.21e-01 | 0.5249 |
54897 | CASZ1 | CCI_3 | Human | Cervix | CC | 1.78e-09 | 7.41e-01 | 0.516 |
54897 | CASZ1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.75e-04 | -2.24e-01 | 0.0155 |
54897 | CASZ1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.54e-02 | 4.57e-01 | -0.1464 |
54897 | CASZ1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.23e-14 | -5.06e-01 | 0.294 |
54897 | CASZ1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.06e-03 | -2.68e-01 | 0.3005 |
54897 | CASZ1 | A002-C-010 | Human | Colorectum | FAP | 1.28e-07 | -2.84e-01 | 0.242 |
54897 | CASZ1 | A015-C-203 | Human | Colorectum | FAP | 4.67e-28 | -3.76e-01 | -0.1294 |
54897 | CASZ1 | A015-C-204 | Human | Colorectum | FAP | 1.68e-07 | -2.32e-01 | -0.0228 |
54897 | CASZ1 | A014-C-040 | Human | Colorectum | FAP | 1.20e-05 | -4.22e-01 | -0.1184 |
54897 | CASZ1 | A002-C-201 | Human | Colorectum | FAP | 4.11e-15 | -2.32e-01 | 0.0324 |
54897 | CASZ1 | A002-C-203 | Human | Colorectum | FAP | 1.33e-04 | -1.45e-01 | 0.2786 |
54897 | CASZ1 | A001-C-119 | Human | Colorectum | FAP | 1.99e-05 | -4.16e-02 | -0.1557 |
54897 | CASZ1 | A001-C-108 | Human | Colorectum | FAP | 1.46e-12 | -1.87e-01 | -0.0272 |
54897 | CASZ1 | A002-C-205 | Human | Colorectum | FAP | 9.27e-23 | -3.26e-01 | -0.1236 |
54897 | CASZ1 | A015-C-005 | Human | Colorectum | FAP | 1.53e-03 | -4.22e-02 | -0.0336 |
54897 | CASZ1 | A015-C-006 | Human | Colorectum | FAP | 2.51e-16 | -2.54e-01 | -0.0994 |
54897 | CASZ1 | A015-C-106 | Human | Colorectum | FAP | 2.72e-13 | -2.56e-01 | -0.0511 |
54897 | CASZ1 | A002-C-114 | Human | Colorectum | FAP | 2.92e-20 | -3.06e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CASZ1 | SNV | Missense_Mutation | novel | c.2303N>T | p.Pro768Leu | p.P768L | Q86V15 | protein_coding | deleterious_low_confidence(0) | benign(0.052) | TCGA-VQ-A94U-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CASZ1 | deletion | Frame_Shift_Del | novel | c.3342delC | p.Thr1115ProfsTer35 | p.T1115Pfs*35 | Q86V15 | protein_coding | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
CASZ1 | deletion | Frame_Shift_Del | novel | c.232delC | p.Arg78AlafsTer10 | p.R78Afs*10 | Q86V15 | protein_coding | TCGA-VQ-A8E3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
CASZ1 | SNV | Missense_Mutation | c.546N>A | p.Met182Ile | p.M182I | Q86V15 | protein_coding | deleterious_low_confidence(0.03) | benign(0.085) | TCGA-EM-A1YB-01 | Thyroid | thyroid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CASZ1 | SNV | Missense_Mutation | novel | c.2386N>T | p.Pro796Ser | p.P796S | Q86V15 | protein_coding | tolerated_low_confidence(0.11) | benign(0.085) | TCGA-ET-A4KN-01 | Thyroid | thyroid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CASZ1 | SNV | Missense_Mutation | c.1677N>A | p.Asn559Lys | p.N559K | Q86V15 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-J8-A3YE-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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