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Gene: BDP1 |
Gene summary for BDP1 |
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Gene information | Species | Human | Gene symbol | BDP1 | Gene ID | 55814 |
Gene name | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | |
Gene Alias | DFNB112 | |
Cytomap | 5q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A6H8Y1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55814 | BDP1 | CCI_2 | Human | Cervix | CC | 4.25e-06 | 7.85e-01 | 0.5249 |
55814 | BDP1 | CCI_3 | Human | Cervix | CC | 1.85e-02 | 5.13e-01 | 0.516 |
55814 | BDP1 | Tumor | Human | Cervix | CC | 1.55e-04 | -3.08e-01 | 0.1241 |
55814 | BDP1 | sample3 | Human | Cervix | CC | 4.83e-04 | -2.44e-01 | 0.1387 |
55814 | BDP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.29e-09 | -5.38e-01 | 0.0155 |
55814 | BDP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.48e-03 | -5.48e-01 | -0.1207 |
55814 | BDP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.12e-06 | -3.83e-01 | 0.294 |
55814 | BDP1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.12e-04 | -3.18e-01 | 0.3859 |
55814 | BDP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.16e-07 | -4.36e-01 | 0.3005 |
55814 | BDP1 | A002-C-010 | Human | Colorectum | FAP | 3.57e-04 | -6.49e-02 | 0.242 |
55814 | BDP1 | A015-C-203 | Human | Colorectum | FAP | 1.36e-26 | 1.26e-01 | -0.1294 |
55814 | BDP1 | A015-C-204 | Human | Colorectum | FAP | 4.95e-06 | 2.25e-01 | -0.0228 |
55814 | BDP1 | A014-C-040 | Human | Colorectum | FAP | 3.17e-02 | 6.32e-02 | -0.1184 |
55814 | BDP1 | A002-C-201 | Human | Colorectum | FAP | 4.19e-09 | 4.87e-02 | 0.0324 |
55814 | BDP1 | A001-C-119 | Human | Colorectum | FAP | 4.62e-26 | 6.11e-01 | -0.1557 |
55814 | BDP1 | A001-C-108 | Human | Colorectum | FAP | 4.02e-22 | 3.84e-01 | -0.0272 |
55814 | BDP1 | A002-C-021 | Human | Colorectum | FAP | 3.25e-02 | 3.17e-01 | 0.1171 |
55814 | BDP1 | A002-C-205 | Human | Colorectum | FAP | 1.57e-40 | 6.20e-01 | -0.1236 |
55814 | BDP1 | A014-C-108 | Human | Colorectum | FAP | 4.62e-06 | 3.94e-01 | -0.124 |
55814 | BDP1 | A001-C-104 | Human | Colorectum | FAP | 1.02e-10 | 4.22e-01 | 0.0184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063833 | Esophagus | ESCC | transcription by RNA polymerase III | 41/8552 | 46/18723 | 7.69e-10 | 1.90e-08 | 41 |
GO:000635211 | Esophagus | ESCC | DNA-templated transcription, initiation | 86/8552 | 130/18723 | 1.88e-06 | 2.19e-05 | 86 |
GO:00708973 | Esophagus | ESCC | transcription preinitiation complex assembly | 30/8552 | 36/18723 | 3.60e-06 | 3.95e-05 | 30 |
GO:0070897 | Liver | Cirrhotic | transcription preinitiation complex assembly | 17/4634 | 36/18723 | 2.82e-03 | 1.63e-02 | 17 |
GO:0006352 | Liver | HCC | DNA-templated transcription, initiation | 78/7958 | 130/18723 | 4.19e-05 | 4.11e-04 | 78 |
GO:0006383 | Liver | HCC | transcription by RNA polymerase III | 31/7958 | 46/18723 | 5.67e-04 | 3.61e-03 | 31 |
GO:00708971 | Liver | HCC | transcription preinitiation complex assembly | 25/7958 | 36/18723 | 9.87e-04 | 5.71e-03 | 25 |
GO:00063832 | Oral cavity | OSCC | transcription by RNA polymerase III | 34/7305 | 46/18723 | 1.61e-06 | 2.11e-05 | 34 |
GO:00063522 | Oral cavity | OSCC | DNA-templated transcription, initiation | 74/7305 | 130/18723 | 2.56e-05 | 2.39e-04 | 74 |
GO:00708972 | Oral cavity | OSCC | transcription preinitiation complex assembly | 24/7305 | 36/18723 | 7.18e-04 | 3.95e-03 | 24 |
GO:0071824 | Skin | AK | protein-DNA complex subunit organization | 38/1910 | 241/18723 | 4.43e-03 | 2.57e-02 | 38 |
GO:00063524 | Skin | AK | DNA-templated transcription, initiation | 23/1910 | 130/18723 | 6.10e-03 | 3.29e-02 | 23 |
GO:000635212 | Skin | cSCC | DNA-templated transcription, initiation | 57/4864 | 130/18723 | 7.28e-06 | 1.01e-04 | 57 |
GO:00708974 | Skin | cSCC | transcription preinitiation complex assembly | 21/4864 | 36/18723 | 3.98e-05 | 4.26e-04 | 21 |
GO:00718241 | Skin | cSCC | protein-DNA complex subunit organization | 87/4864 | 241/18723 | 3.09e-04 | 2.47e-03 | 87 |
GO:00063834 | Skin | cSCC | transcription by RNA polymerase III | 20/4864 | 46/18723 | 7.44e-03 | 3.50e-02 | 20 |
GO:00063525 | Thyroid | PTC | DNA-templated transcription, initiation | 63/5968 | 130/18723 | 5.72e-05 | 5.05e-04 | 63 |
GO:00708975 | Thyroid | PTC | transcription preinitiation complex assembly | 22/5968 | 36/18723 | 2.85e-04 | 2.02e-03 | 22 |
GO:00063835 | Thyroid | PTC | transcription by RNA polymerase III | 23/5968 | 46/18723 | 7.89e-03 | 3.33e-02 | 23 |
GO:000635213 | Thyroid | ATC | DNA-templated transcription, initiation | 64/6293 | 130/18723 | 1.60e-04 | 1.10e-03 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BDP1 | SNV | Missense_Mutation | c.6659N>T | p.Asp2220Val | p.D2220V | A6H8Y1 | protein_coding | deleterious(0.02) | benign(0.124) | TCGA-BW-A5NQ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
BDP1 | SNV | Missense_Mutation | c.951G>T | p.Met317Ile | p.M317I | A6H8Y1 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-DD-A3A8-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BDP1 | SNV | Missense_Mutation | c.12G>T | p.Arg4Ser | p.R4S | A6H8Y1 | protein_coding | deleterious(0) | probably_damaging(0.923) | TCGA-DD-A4NF-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
BDP1 | SNV | Missense_Mutation | novel | c.2823N>T | p.Lys941Asn | p.K941N | A6H8Y1 | protein_coding | deleterious(0.02) | benign(0) | TCGA-G3-AAV3-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BDP1 | SNV | Missense_Mutation | c.643C>G | p.Pro215Ala | p.P215A | A6H8Y1 | protein_coding | tolerated(0.2) | possibly_damaging(0.54) | TCGA-05-4250-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
BDP1 | SNV | Missense_Mutation | novel | c.4768N>G | p.Gln1590Glu | p.Q1590E | A6H8Y1 | protein_coding | tolerated(0.12) | benign(0.208) | TCGA-05-4420-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
BDP1 | SNV | Missense_Mutation | c.4939C>G | p.Gln1647Glu | p.Q1647E | A6H8Y1 | protein_coding | tolerated(0.1) | benign(0.01) | TCGA-35-5375-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
BDP1 | SNV | Missense_Mutation | c.2281G>C | p.Glu761Gln | p.E761Q | A6H8Y1 | protein_coding | tolerated(0.19) | benign(0.049) | TCGA-38-4625-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BDP1 | SNV | Missense_Mutation | rs754948193 | c.1961A>T | p.His654Leu | p.H654L | A6H8Y1 | protein_coding | tolerated(0.36) | benign(0.013) | TCGA-44-2656-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
BDP1 | SNV | Missense_Mutation | rs752122551 | c.2387N>G | p.Asn796Ser | p.N796S | A6H8Y1 | protein_coding | tolerated(0.48) | benign(0.189) | TCGA-44-7667-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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