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Gene: ATP10D |
Gene summary for ATP10D |
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Gene information | Species | Human | Gene symbol | ATP10D | Gene ID | 57205 |
Gene name | ATPase phospholipid transporting 10D (putative) | |
Gene Alias | ATPVD | |
Cytomap | 4p12 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9P241 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57205 | ATP10D | LZE2T | Human | Esophagus | ESCC | 3.22e-03 | 3.84e-01 | 0.082 |
57205 | ATP10D | LZE4T | Human | Esophagus | ESCC | 2.36e-09 | 3.24e-01 | 0.0811 |
57205 | ATP10D | LZE20T | Human | Esophagus | ESCC | 3.59e-02 | 3.72e-02 | 0.0662 |
57205 | ATP10D | P1T-E | Human | Esophagus | ESCC | 5.63e-03 | 2.31e-01 | 0.0875 |
57205 | ATP10D | P2T-E | Human | Esophagus | ESCC | 2.05e-16 | 3.12e-01 | 0.1177 |
57205 | ATP10D | P4T-E | Human | Esophagus | ESCC | 1.09e-17 | 2.99e-01 | 0.1323 |
57205 | ATP10D | P5T-E | Human | Esophagus | ESCC | 3.73e-07 | 7.70e-02 | 0.1327 |
57205 | ATP10D | P8T-E | Human | Esophagus | ESCC | 1.67e-12 | 1.35e-01 | 0.0889 |
57205 | ATP10D | P9T-E | Human | Esophagus | ESCC | 7.89e-07 | 4.65e-02 | 0.1131 |
57205 | ATP10D | P11T-E | Human | Esophagus | ESCC | 1.17e-07 | 4.44e-01 | 0.1426 |
57205 | ATP10D | P12T-E | Human | Esophagus | ESCC | 3.19e-15 | 1.97e-01 | 0.1122 |
57205 | ATP10D | P15T-E | Human | Esophagus | ESCC | 1.26e-07 | 2.44e-01 | 0.1149 |
57205 | ATP10D | P16T-E | Human | Esophagus | ESCC | 5.24e-04 | 4.53e-02 | 0.1153 |
57205 | ATP10D | P20T-E | Human | Esophagus | ESCC | 1.21e-11 | 3.40e-01 | 0.1124 |
57205 | ATP10D | P21T-E | Human | Esophagus | ESCC | 3.44e-14 | 2.72e-01 | 0.1617 |
57205 | ATP10D | P22T-E | Human | Esophagus | ESCC | 2.99e-05 | 5.83e-02 | 0.1236 |
57205 | ATP10D | P23T-E | Human | Esophagus | ESCC | 2.97e-07 | 1.03e-01 | 0.108 |
57205 | ATP10D | P24T-E | Human | Esophagus | ESCC | 3.01e-06 | 1.38e-01 | 0.1287 |
57205 | ATP10D | P26T-E | Human | Esophagus | ESCC | 1.64e-16 | 2.52e-01 | 0.1276 |
57205 | ATP10D | P27T-E | Human | Esophagus | ESCC | 2.86e-11 | 2.61e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00157483 | Oral cavity | EOLP | organophosphate ester transport | 28/2218 | 140/18723 | 3.66e-03 | 2.05e-02 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP10D | SNV | Missense_Mutation | novel | c.1120T>C | p.Trp374Arg | p.W374R | Q9P241 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-58-8386-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ATP10D | SNV | Missense_Mutation | rs561130132 | c.1756G>A | p.Asp586Asn | p.D586N | Q9P241 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-60-2710-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | pemetrexed | SD |
ATP10D | SNV | Missense_Mutation | c.1042N>A | p.Glu348Lys | p.E348K | Q9P241 | protein_coding | tolerated(0.25) | benign(0.007) | TCGA-66-2766-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
ATP10D | SNV | Missense_Mutation | c.259G>C | p.Val87Leu | p.V87L | Q9P241 | protein_coding | tolerated(1) | benign(0) | TCGA-66-2789-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ATP10D | SNV | Missense_Mutation | c.3214N>T | p.Gly1072Trp | p.G1072W | Q9P241 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-68-7757-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ATP10D | SNV | Missense_Mutation | novel | c.2617G>C | p.Glu873Gln | p.E873Q | Q9P241 | protein_coding | tolerated(0.13) | benign(0.192) | TCGA-68-8251-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
ATP10D | SNV | Missense_Mutation | novel | c.3949T>C | p.Tyr1317His | p.Y1317H | Q9P241 | protein_coding | deleterious(0.05) | possibly_damaging(0.76) | TCGA-77-6843-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ATP10D | SNV | Missense_Mutation | novel | c.2483A>T | p.Gln828Leu | p.Q828L | Q9P241 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-90-A59Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
ATP10D | SNV | Missense_Mutation | novel | c.3706N>T | p.Ala1236Ser | p.A1236S | Q9P241 | protein_coding | tolerated(0.36) | benign(0.099) | TCGA-94-A5I6-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ATP10D | SNV | Missense_Mutation | rs766813065 | c.512N>A | p.Cys171Tyr | p.C171Y | Q9P241 | protein_coding | tolerated(1) | benign(0.035) | TCGA-98-7454-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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