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Gene: ATAD5 |
Gene summary for ATAD5 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ATAD5 | Gene ID | 79915 |
Gene name | ATPase family AAA domain containing 5 | |
Gene Alias | C17orf41 | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006260 | UniProtAcc | Q96QE3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79915 | ATAD5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.99e-02 | 3.18e-01 | -0.0811 |
79915 | ATAD5 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.58e-09 | 4.89e-01 | -0.1954 |
79915 | ATAD5 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.86e-03 | 6.84e-01 | -0.2602 |
79915 | ATAD5 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.45e-03 | 3.14e-01 | -0.1464 |
79915 | ATAD5 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.07e-06 | 3.42e-01 | -0.1001 |
79915 | ATAD5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.25e-04 | 4.25e-01 | -0.059 |
79915 | ATAD5 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.64e-03 | 4.12e-01 | -0.0842 |
79915 | ATAD5 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.46e-02 | 2.37e-01 | 0.0674 |
79915 | ATAD5 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.40e-05 | 4.69e-01 | 0.3859 |
79915 | ATAD5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.12e-07 | 3.68e-01 | 0.3005 |
79915 | ATAD5 | A002-C-116 | Human | Colorectum | FAP | 1.91e-02 | -3.04e-02 | -0.0452 |
79915 | ATAD5 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.16e-04 | 9.23e-03 | -0.1883 |
79915 | ATAD5 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.49e-04 | -4.61e-03 | -0.1916 |
79915 | ATAD5 | LZE7T | Human | Esophagus | ESCC | 2.55e-08 | 4.26e-01 | 0.0667 |
79915 | ATAD5 | LZE24T | Human | Esophagus | ESCC | 1.91e-02 | 1.52e-01 | 0.0596 |
79915 | ATAD5 | P1T-E | Human | Esophagus | ESCC | 2.46e-05 | 3.77e-01 | 0.0875 |
79915 | ATAD5 | P2T-E | Human | Esophagus | ESCC | 6.38e-31 | 6.32e-01 | 0.1177 |
79915 | ATAD5 | P4T-E | Human | Esophagus | ESCC | 5.71e-08 | 2.43e-01 | 0.1323 |
79915 | ATAD5 | P5T-E | Human | Esophagus | ESCC | 3.60e-13 | 2.74e-01 | 0.1327 |
79915 | ATAD5 | P8T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.46e-01 | 0.0889 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0045787 | Colorectum | AD | positive regulation of cell cycle | 85/3918 | 313/18723 | 4.76e-03 | 3.22e-02 | 85 |
GO:00457871 | Colorectum | MSS | positive regulation of cell cycle | 80/3467 | 313/18723 | 1.15e-03 | 1.12e-02 | 80 |
GO:0090068 | Colorectum | MSS | positive regulation of cell cycle process | 60/3467 | 236/18723 | 5.01e-03 | 3.46e-02 | 60 |
GO:00457872 | Colorectum | FAP | positive regulation of cell cycle | 66/2622 | 313/18723 | 3.66e-04 | 4.63e-03 | 66 |
GO:00900681 | Colorectum | FAP | positive regulation of cell cycle process | 48/2622 | 236/18723 | 4.53e-03 | 3.08e-02 | 48 |
GO:004578713 | Endometrium | EEC | positive regulation of cell cycle | 59/2168 | 313/18723 | 1.04e-04 | 1.44e-03 | 59 |
GO:009006812 | Endometrium | EEC | positive regulation of cell cycle process | 44/2168 | 236/18723 | 9.39e-04 | 8.42e-03 | 44 |
GO:000627511 | Endometrium | EEC | regulation of DNA replication | 22/2168 | 107/18723 | 5.09e-03 | 3.20e-02 | 22 |
GO:19019893 | Endometrium | EEC | positive regulation of cell cycle phase transition | 23/2168 | 115/18723 | 6.04e-03 | 3.57e-02 | 23 |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:004578710 | Esophagus | ESCC | positive regulation of cell cycle | 196/8552 | 313/18723 | 9.27e-10 | 2.24e-08 | 196 |
GO:00448394 | Esophagus | ESCC | cell cycle G2/M phase transition | 103/8552 | 148/18723 | 3.09e-09 | 6.67e-08 | 103 |
GO:00062754 | Esophagus | ESCC | regulation of DNA replication | 73/8552 | 107/18723 | 1.97e-06 | 2.28e-05 | 73 |
GO:19019896 | Esophagus | ESCC | positive regulation of cell cycle phase transition | 77/8552 | 115/18723 | 3.20e-06 | 3.58e-05 | 77 |
GO:00900689 | Esophagus | ESCC | positive regulation of cell cycle process | 142/8552 | 236/18723 | 4.79e-06 | 5.08e-05 | 142 |
GO:19027491 | Esophagus | ESCC | regulation of cell cycle G2/M phase transition | 68/8552 | 102/18723 | 1.48e-05 | 1.33e-04 | 68 |
GO:19027511 | Esophagus | ESCC | positive regulation of cell cycle G2/M phase transition | 22/8552 | 30/18723 | 1.98e-03 | 8.90e-03 | 22 |
GO:00457406 | Esophagus | ESCC | positive regulation of DNA replication | 26/8552 | 40/18723 | 1.08e-02 | 3.66e-02 | 26 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATAD5 | deletion | Frame_Shift_Del | novel | c.1996delN | p.Lys667AsnfsTer40 | p.K667Nfs*40 | Q96QE3 | protein_coding | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | ||
ATAD5 | deletion | Frame_Shift_Del | c.3573delN | p.Phe1193LeufsTer6 | p.F1193Lfs*6 | Q96QE3 | protein_coding | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD | |||
ATAD5 | insertion | Frame_Shift_Ins | novel | c.812_813insA | p.Ser273LysfsTer6 | p.S273Kfs*6 | Q96QE3 | protein_coding | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
ATAD5 | insertion | Frame_Shift_Ins | novel | c.4904_4905insA | p.Cys1638MetfsTer14 | p.C1638Mfs*14 | Q96QE3 | protein_coding | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
ATAD5 | insertion | Frame_Shift_Ins | novel | c.2007_2008insA | p.Ser672IlefsTer2 | p.S672Ifs*2 | Q96QE3 | protein_coding | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |||
ATAD5 | SNV | Missense_Mutation | c.3322N>A | p.Gly1108Ser | p.G1108S | Q96QE3 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-EL-A3MX-01 | Thyroid | thyroid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ATAD5 | SNV | Missense_Mutation | novel | c.3698N>G | p.Pro1233Arg | p.P1233R | Q96QE3 | protein_coding | deleterious(0) | possibly_damaging(0.567) | TCGA-EL-A3ZO-01 | Thyroid | thyroid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ATAD5 | insertion | Frame_Shift_Ins | novel | c.1667_1668insCCTGGAA | p.Asn557LeufsTer3 | p.N557Lfs*3 | Q96QE3 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
ATAD5 | insertion | Frame_Shift_Ins | novel | c.3727_3728insATAAA | p.Val1243AspfsTer13 | p.V1243Dfs*13 | Q96QE3 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
79915 | ATAD5 | NA | DOMPERIDONE | DOMPERIDONE | ||
79915 | ATAD5 | NA | DNDI1417132 | CHEMBL1492017 | ||
79915 | ATAD5 | NA | EMETINE | EMETINE | ||
79915 | ATAD5 | NA | GNF-PF-4418 | CHEMBL604321 | ||
79915 | ATAD5 | NA | GNF-PF-5159 | CHEMBL1493528 | ||
79915 | ATAD5 | NA | GNF-PF-5183 | CHEMBL577660 | ||
79915 | ATAD5 | NA | DICHLORORIBOBENZIMIDAZOLE | DICHLORORIBOBENZIMIDAZOLE | ||
79915 | ATAD5 | NA | DNDI1417195 | CHEMBL1303948 | ||
79915 | ATAD5 | NA | 4,5,6,7-TETRABROMOBENZIMIDAZOLE | CHEMBL373937 | ||
79915 | ATAD5 | NA | 4'-HYDROXYPHENYL-BENZO[D]THIAZOLE | CHEMBL47875 |
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