![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ARFGEF3 |
Gene summary for ARFGEF3 |
![]() |
Gene information | Species | Human | Gene symbol | ARFGEF3 | Gene ID | 57221 |
Gene name | ARFGEF family member 3 | |
Gene Alias | A7322 | |
Cytomap | 6q23.3-q24.1 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q5TH69 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57221 | ARFGEF3 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.18e-04 | 5.80e-01 | -0.1088 |
57221 | ARFGEF3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.12e-05 | 1.10e+00 | 0.3487 |
57221 | ARFGEF3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.72e-09 | 7.19e-01 | 0.281 |
57221 | ARFGEF3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.89e-03 | -1.36e-01 | 0.3005 |
57221 | ARFGEF3 | A001-C-207 | Human | Colorectum | FAP | 4.53e-02 | -1.40e-02 | 0.1278 |
57221 | ARFGEF3 | A015-C-203 | Human | Colorectum | FAP | 1.06e-27 | -3.57e-01 | -0.1294 |
57221 | ARFGEF3 | A015-C-204 | Human | Colorectum | FAP | 3.57e-05 | -2.02e-01 | -0.0228 |
57221 | ARFGEF3 | A014-C-040 | Human | Colorectum | FAP | 3.16e-03 | -3.02e-01 | -0.1184 |
57221 | ARFGEF3 | A002-C-201 | Human | Colorectum | FAP | 2.18e-07 | -2.16e-01 | 0.0324 |
57221 | ARFGEF3 | A001-C-119 | Human | Colorectum | FAP | 5.91e-05 | -2.98e-01 | -0.1557 |
57221 | ARFGEF3 | A001-C-108 | Human | Colorectum | FAP | 2.53e-12 | -1.13e-01 | -0.0272 |
57221 | ARFGEF3 | A002-C-205 | Human | Colorectum | FAP | 4.33e-19 | -4.17e-01 | -0.1236 |
57221 | ARFGEF3 | A015-C-006 | Human | Colorectum | FAP | 2.95e-10 | -2.48e-01 | -0.0994 |
57221 | ARFGEF3 | A015-C-106 | Human | Colorectum | FAP | 4.40e-08 | -1.83e-01 | -0.0511 |
57221 | ARFGEF3 | A002-C-114 | Human | Colorectum | FAP | 7.74e-14 | -3.14e-01 | -0.1561 |
57221 | ARFGEF3 | A015-C-104 | Human | Colorectum | FAP | 5.86e-26 | -2.19e-01 | -0.1899 |
57221 | ARFGEF3 | A001-C-014 | Human | Colorectum | FAP | 2.21e-13 | -2.05e-01 | 0.0135 |
57221 | ARFGEF3 | A002-C-016 | Human | Colorectum | FAP | 1.87e-18 | -2.17e-01 | 0.0521 |
57221 | ARFGEF3 | A015-C-002 | Human | Colorectum | FAP | 3.03e-09 | -4.05e-01 | -0.0763 |
57221 | ARFGEF3 | A001-C-203 | Human | Colorectum | FAP | 8.30e-06 | -1.31e-01 | -0.0481 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:0046578 | Colorectum | AD | regulation of Ras protein signal transduction | 56/3918 | 189/18723 | 2.85e-03 | 2.14e-02 | 56 |
GO:00072651 | Colorectum | MSS | Ras protein signal transduction | 91/3467 | 337/18723 | 7.20e-05 | 1.21e-03 | 91 |
GO:00510561 | Colorectum | MSS | regulation of small GTPase mediated signal transduction | 82/3467 | 302/18723 | 1.31e-04 | 1.99e-03 | 82 |
GO:00510562 | Colorectum | FAP | regulation of small GTPase mediated signal transduction | 78/2622 | 302/18723 | 3.25e-08 | 2.85e-06 | 78 |
GO:00072652 | Colorectum | FAP | Ras protein signal transduction | 80/2622 | 337/18723 | 9.61e-07 | 4.33e-05 | 80 |
GO:00465781 | Colorectum | FAP | regulation of Ras protein signal transduction | 47/2622 | 189/18723 | 4.67e-05 | 9.60e-04 | 47 |
GO:00510563 | Colorectum | CRC | regulation of small GTPase mediated signal transduction | 69/2078 | 302/18723 | 3.34e-09 | 9.08e-07 | 69 |
GO:00072653 | Colorectum | CRC | Ras protein signal transduction | 70/2078 | 337/18723 | 1.49e-07 | 1.66e-05 | 70 |
GO:00465782 | Colorectum | CRC | regulation of Ras protein signal transduction | 43/2078 | 189/18723 | 3.26e-06 | 1.47e-04 | 43 |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
GO:00465789 | Esophagus | ESCC | regulation of Ras protein signal transduction | 106/8552 | 189/18723 | 2.49e-03 | 1.08e-02 | 106 |
GO:005105610 | Esophagus | ESCC | regulation of small GTPase mediated signal transduction | 157/8552 | 302/18723 | 1.55e-02 | 4.98e-02 | 157 |
GO:000726521 | Liver | HCC | Ras protein signal transduction | 187/7958 | 337/18723 | 8.89e-07 | 1.35e-05 | 187 |
GO:004657811 | Liver | HCC | regulation of Ras protein signal transduction | 100/7958 | 189/18723 | 2.42e-03 | 1.18e-02 | 100 |
GO:00510565 | Lung | IAC | regulation of small GTPase mediated signal transduction | 70/2061 | 302/18723 | 9.44e-10 | 1.87e-07 | 70 |
GO:00072655 | Lung | IAC | Ras protein signal transduction | 65/2061 | 337/18723 | 4.48e-06 | 1.81e-04 | 65 |
GO:00465784 | Lung | IAC | regulation of Ras protein signal transduction | 40/2061 | 189/18723 | 3.50e-05 | 8.65e-04 | 40 |
GO:0032011 | Lung | IAC | ARF protein signal transduction | 8/2061 | 19/18723 | 5.25e-04 | 7.44e-03 | 8 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARFGEF3 | SNV | Missense_Mutation | novel | c.5548N>A | p.Asp1850Asn | p.D1850N | Q5TH69 | protein_coding | tolerated(0.13) | benign(0.188) | TCGA-D6-A74Q-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARFGEF3 | SNV | Missense_Mutation | novel | c.928N>G | p.Thr310Ala | p.T310A | Q5TH69 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-DQ-5630-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARFGEF3 | SNV | Missense_Mutation | novel | c.1982N>G | p.Lys661Arg | p.K661R | Q5TH69 | protein_coding | tolerated(0.21) | benign(0.006) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ARFGEF3 | SNV | Missense_Mutation | c.5671N>T | p.Pro1891Ser | p.P1891S | Q5TH69 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-HC-A4ZV-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
ARFGEF3 | SNV | Missense_Mutation | novel | c.5578N>A | p.Glu1860Lys | p.E1860K | Q5TH69 | protein_coding | deleterious(0.05) | possibly_damaging(0.874) | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
ARFGEF3 | SNV | Missense_Mutation | c.2989N>G | p.Leu997Val | p.L997V | Q5TH69 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-KK-A59X-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | leuprolide | PD | |
ARFGEF3 | SNV | Missense_Mutation | novel | c.1825N>A | p.Asp609Asn | p.D609N | Q5TH69 | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
ARFGEF3 | SNV | Missense_Mutation | rs763602394 | c.2722N>T | p.Arg908Trp | p.R908W | Q5TH69 | protein_coding | deleterious(0) | possibly_damaging(0.849) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
ARFGEF3 | SNV | Missense_Mutation | rs767837982 | c.4963N>A | p.Glu1655Lys | p.E1655K | Q5TH69 | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
ARFGEF3 | SNV | Missense_Mutation | c.1604N>A | p.Ser535Asn | p.S535N | Q5TH69 | protein_coding | tolerated(0.31) | benign(0.013) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |