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Gene: ADAMTS2 |
Gene summary for ADAMTS2 |
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Gene information | Species | Human | Gene symbol | ADAMTS2 | Gene ID | 9509 |
Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 2 | |
Gene Alias | ADAM-TS2 | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O95450 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9509 | ADAMTS2 | ATC12 | Human | Thyroid | ATC | 1.72e-28 | 6.12e-01 | 0.34 |
9509 | ADAMTS2 | ATC13 | Human | Thyroid | ATC | 3.04e-38 | 6.43e-01 | 0.34 |
9509 | ADAMTS2 | ATC2 | Human | Thyroid | ATC | 2.49e-06 | 6.31e-01 | 0.34 |
9509 | ADAMTS2 | ATC4 | Human | Thyroid | ATC | 1.32e-34 | 7.35e-01 | 0.34 |
9509 | ADAMTS2 | ATC5 | Human | Thyroid | ATC | 8.04e-38 | 7.08e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003019812 | Thyroid | ATC | extracellular matrix organization | 152/6293 | 301/18723 | 8.63e-10 | 2.24e-08 | 152 |
GO:004306212 | Thyroid | ATC | extracellular structure organization | 152/6293 | 302/18723 | 1.17e-09 | 2.94e-08 | 152 |
GO:004522912 | Thyroid | ATC | external encapsulating structure organization | 152/6293 | 304/18723 | 2.11e-09 | 5.08e-08 | 152 |
GO:003019911 | Thyroid | ATC | collagen fibril organization | 43/6293 | 61/18723 | 4.24e-09 | 9.57e-08 | 43 |
GO:003032321 | Thyroid | ATC | respiratory tube development | 93/6293 | 181/18723 | 5.67e-07 | 8.02e-06 | 93 |
GO:003032421 | Thyroid | ATC | lung development | 90/6293 | 177/18723 | 1.53e-06 | 1.88e-05 | 90 |
GO:006054121 | Thyroid | ATC | respiratory system development | 100/6293 | 203/18723 | 2.66e-06 | 3.08e-05 | 100 |
GO:0051604110 | Thyroid | ATC | protein maturation | 136/6293 | 294/18723 | 4.00e-06 | 4.42e-05 | 136 |
GO:00329633 | Thyroid | ATC | collagen metabolic process | 52/6293 | 104/18723 | 3.94e-04 | 2.38e-03 | 52 |
GO:001648515 | Thyroid | ATC | protein processing | 100/6293 | 225/18723 | 4.39e-04 | 2.62e-03 | 100 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAMTS2 | SNV | Missense_Mutation | novel | c.3171N>G | p.Ile1057Met | p.I1057M | O95450 | protein_coding | tolerated(0.06) | benign(0.143) | TCGA-77-7141-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADAMTS2 | SNV | Missense_Mutation | c.2053G>T | p.Ala685Ser | p.A685S | O95450 | protein_coding | tolerated(0.09) | benign(0.018) | TCGA-85-8481-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ADAMTS2 | SNV | Missense_Mutation | novel | c.1490N>C | p.Gly497Ala | p.G497A | O95450 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-85-8582-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADAMTS2 | SNV | Missense_Mutation | rs546681307 | c.1414G>A | p.Ala472Thr | p.A472T | O95450 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-CN-4736-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
ADAMTS2 | SNV | Missense_Mutation | rs144554943 | c.2036G>A | p.Arg679His | p.R679H | O95450 | protein_coding | deleterious(0.03) | benign(0.026) | TCGA-CN-A63V-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADAMTS2 | SNV | Missense_Mutation | rs373406403 | c.303N>A | p.Asn101Lys | p.N101K | O95450 | protein_coding | tolerated(0.81) | benign(0.03) | TCGA-CR-7399-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ADAMTS2 | SNV | Missense_Mutation | c.2471N>A | p.Gly824Glu | p.G824E | O95450 | protein_coding | tolerated(0.25) | probably_damaging(0.994) | TCGA-CV-A468-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ADAMTS2 | SNV | Missense_Mutation | rs867353605 | c.2470N>A | p.Gly824Arg | p.G824R | O95450 | protein_coding | tolerated(0.06) | probably_damaging(0.997) | TCGA-CV-A468-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADAMTS2 | SNV | Missense_Mutation | novel | c.2896N>T | p.Ser966Cys | p.S966C | O95450 | protein_coding | deleterious(0.01) | possibly_damaging(0.807) | TCGA-UF-A71E-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ADAMTS2 | SNV | Missense_Mutation | c.853G>A | p.Glu285Lys | p.E285K | O95450 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-EJ-7123-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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