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Gene: WDR49 |
Gene summary for WDR49 |
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Gene information | Species | Human | Gene symbol | WDR49 | Gene ID | 151790 |
Gene name | WD repeat domain 49 | |
Gene Alias | WDR49 | |
Cytomap | 3q26.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
151790 | WDR49 | LZE21D1 | Human | Esophagus | HGIN | 5.38e-03 | 5.71e-01 | 0.0632 |
151790 | WDR49 | LZE24T | Human | Esophagus | ESCC | 1.80e-03 | 1.50e-01 | 0.0596 |
151790 | WDR49 | LZE21T | Human | Esophagus | ESCC | 2.27e-11 | 6.03e-01 | 0.0655 |
151790 | WDR49 | P2T-E | Human | Esophagus | ESCC | 2.06e-08 | 2.07e-01 | 0.1177 |
151790 | WDR49 | P8T-E | Human | Esophagus | ESCC | 6.56e-15 | 2.59e-01 | 0.0889 |
151790 | WDR49 | P27T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.38e-01 | 0.1055 |
151790 | WDR49 | P48T-E | Human | Esophagus | ESCC | 1.88e-11 | 2.33e-01 | 0.0959 |
151790 | WDR49 | P62T-E | Human | Esophagus | ESCC | 7.83e-12 | 2.59e-01 | 0.1302 |
151790 | WDR49 | P74T-E | Human | Esophagus | ESCC | 2.66e-02 | 1.19e-01 | 0.1479 |
151790 | WDR49 | P128T-E | Human | Esophagus | ESCC | 2.93e-10 | 3.01e-01 | 0.1241 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR49 | SNV | Missense_Mutation | rs778938192 | c.179N>A | p.Gly60Asp | p.G60D | Q8IV35 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-VQ-AA6K-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD |
WDR49 | deletion | Frame_Shift_Del | rs755423544 | c.1821delA | p.Lys607AsnfsTer9 | p.K607Nfs*9 | Q8IV35 | protein_coding | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
WDR49 | deletion | Frame_Shift_Del | rs755423544 | c.1821delN | p.Lys607AsnfsTer9 | p.K607Nfs*9 | Q8IV35 | protein_coding | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD | ||
WDR49 | deletion | Frame_Shift_Del | rs755423544 | c.1821delA | p.Lys607AsnfsTer9 | p.K607Nfs*9 | Q8IV35 | protein_coding | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD | ||
WDR49 | SNV | Missense_Mutation | c.1357N>C | p.Cys453Arg | p.C453R | Q8IV35 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-DJ-A2Q9-01 | Thyroid | thyroid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
WDR49 | SNV | Missense_Mutation | novel | c.352N>A | p.Glu118Lys | p.E118K | Q8IV35 | protein_coding | tolerated(0.06) | possibly_damaging(0.476) | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
WDR49 | insertion | Nonsense_Mutation | novel | c.353_354insGTAAATG | p.Ala119Ter | p.A119* | Q8IV35 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
WDR49 | insertion | Nonsense_Mutation | novel | c.353_354insGTAAATG | p.Ala119Ter | p.A119* | Q8IV35 | protein_coding | TCGA-ET-A40R-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
WDR49 | insertion | Nonsense_Mutation | novel | c.354_355insTTAAGTAAATGA | p.Glu118_Ala119insLeuSerLysTer | p.E118_A119insLSK* | Q8IV35 | protein_coding | TCGA-IM-A41Z-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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