![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: THBS2 |
Gene summary for THBS2 |
![]() |
Gene information | Species | Human | Gene symbol | THBS2 | Gene ID | 7058 |
Gene name | thrombospondin 2 | |
Gene Alias | TSP2 | |
Cytomap | 6q27 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | P35442 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7058 | THBS2 | LZE7T | Human | Esophagus | ESCC | 2.46e-12 | 6.48e-02 | 0.0667 |
7058 | THBS2 | P2T-E | Human | Esophagus | ESCC | 1.54e-03 | -1.91e-01 | 0.1177 |
7058 | THBS2 | P8T-E | Human | Esophagus | ESCC | 2.71e-02 | -1.80e-01 | 0.0889 |
7058 | THBS2 | P11T-E | Human | Esophagus | ESCC | 1.49e-02 | 9.12e-01 | 0.1426 |
7058 | THBS2 | P12T-E | Human | Esophagus | ESCC | 3.77e-05 | -2.05e-01 | 0.1122 |
7058 | THBS2 | P20T-E | Human | Esophagus | ESCC | 2.77e-02 | 2.08e-01 | 0.1124 |
7058 | THBS2 | P26T-E | Human | Esophagus | ESCC | 5.88e-05 | -1.82e-01 | 0.1276 |
7058 | THBS2 | P37T-E | Human | Esophagus | ESCC | 2.65e-44 | 1.60e+00 | 0.1371 |
7058 | THBS2 | P48T-E | Human | Esophagus | ESCC | 1.12e-04 | -1.98e-01 | 0.0959 |
7058 | THBS2 | P76T-E | Human | Esophagus | ESCC | 1.20e-04 | 4.94e-01 | 0.1207 |
7058 | THBS2 | P107T-E | Human | Esophagus | ESCC | 2.64e-02 | -1.99e-01 | 0.171 |
7058 | THBS2 | P127T-E | Human | Esophagus | ESCC | 1.76e-02 | -1.62e-01 | 0.0826 |
7058 | THBS2 | C04 | Human | Oral cavity | OSCC | 1.54e-15 | 8.04e-01 | 0.2633 |
7058 | THBS2 | C21 | Human | Oral cavity | OSCC | 1.88e-25 | 8.53e-01 | 0.2678 |
7058 | THBS2 | C51 | Human | Oral cavity | OSCC | 5.58e-41 | 1.88e+00 | 0.2674 |
7058 | THBS2 | C07 | Human | Oral cavity | OSCC | 5.72e-03 | 1.06e+00 | 0.2491 |
7058 | THBS2 | LP15 | Human | Oral cavity | LP | 8.27e-07 | 1.73e+00 | 0.2174 |
7058 | THBS2 | NEOLP-1 | Human | Oral cavity | NEOLP | 1.07e-13 | 5.66e-01 | -0.0194 |
7058 | THBS2 | SYSMH2 | Human | Oral cavity | OSCC | 2.26e-11 | 4.18e-01 | 0.2326 |
7058 | THBS2 | SYSMH3 | Human | Oral cavity | OSCC | 5.70e-25 | 9.46e-01 | 0.2442 |
Page: 1 2 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003432918 | Esophagus | ESCC | cell junction assembly | 227/8552 | 420/18723 | 3.06e-04 | 1.83e-03 | 227 |
GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
GO:00519625 | Esophagus | ESCC | positive regulation of nervous system development | 149/8552 | 272/18723 | 1.50e-03 | 7.06e-03 | 149 |
GO:190188810 | Esophagus | ESCC | regulation of cell junction assembly | 109/8552 | 204/18723 | 1.53e-02 | 4.96e-02 | 109 |
GO:00519624 | Oral cavity | OSCC | positive regulation of nervous system development | 135/7305 | 272/18723 | 2.20e-04 | 1.44e-03 | 135 |
GO:00519605 | Oral cavity | OSCC | regulation of nervous system development | 205/7305 | 443/18723 | 9.80e-04 | 5.11e-03 | 205 |
GO:003432916 | Oral cavity | OSCC | cell junction assembly | 190/7305 | 420/18723 | 4.99e-03 | 1.96e-02 | 190 |
GO:003432923 | Oral cavity | NEOLP | cell junction assembly | 88/2005 | 420/18723 | 4.18e-10 | 3.44e-08 | 88 |
GO:190188814 | Oral cavity | NEOLP | regulation of cell junction assembly | 47/2005 | 204/18723 | 2.82e-07 | 8.96e-06 | 47 |
GO:190134213 | Oral cavity | NEOLP | regulation of vasculature development | 59/2005 | 348/18723 | 2.42e-04 | 2.52e-03 | 59 |
GO:00457655 | Oral cavity | NEOLP | regulation of angiogenesis | 58/2005 | 342/18723 | 2.70e-04 | 2.72e-03 | 58 |
GO:005196212 | Oral cavity | NEOLP | positive regulation of nervous system development | 47/2005 | 272/18723 | 6.49e-04 | 5.47e-03 | 47 |
GO:005196012 | Oral cavity | NEOLP | regulation of nervous system development | 68/2005 | 443/18723 | 1.46e-03 | 1.03e-02 | 68 |
GO:003432919 | Skin | AK | cell junction assembly | 86/1910 | 420/18723 | 1.95e-10 | 2.68e-08 | 86 |
GO:190188815 | Skin | AK | regulation of cell junction assembly | 43/1910 | 204/18723 | 2.99e-06 | 7.93e-05 | 43 |
GO:00508088 | Skin | AK | synapse organization | 71/1910 | 426/18723 | 2.21e-05 | 4.07e-04 | 71 |
GO:00519607 | Skin | AK | regulation of nervous system development | 72/1910 | 443/18723 | 4.53e-05 | 7.11e-04 | 72 |
GO:00519626 | Skin | AK | positive regulation of nervous system development | 49/1910 | 272/18723 | 5.65e-05 | 8.50e-04 | 49 |
GO:00508031 | Skin | AK | regulation of synapse structure or activity | 38/1910 | 218/18723 | 7.06e-04 | 6.01e-03 | 38 |
GO:00508073 | Skin | AK | regulation of synapse organization | 37/1910 | 211/18723 | 7.35e-04 | 6.20e-03 | 37 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516510 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0414530 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
hsa0451020 | Esophagus | ESCC | Focal adhesion | 127/4205 | 203/8465 | 1.25e-04 | 4.99e-04 | 2.56e-04 | 127 |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0516515 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa04145114 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
hsa04510111 | Esophagus | ESCC | Focal adhesion | 127/4205 | 203/8465 | 1.25e-04 | 4.99e-04 | 2.56e-04 | 127 |
hsa0415114 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa051659 | Oral cavity | OSCC | Human papillomavirus infection | 200/3704 | 331/8465 | 3.83e-10 | 4.93e-09 | 2.51e-09 | 200 |
hsa0451019 | Oral cavity | OSCC | Focal adhesion | 128/3704 | 203/8465 | 1.71e-08 | 1.63e-07 | 8.31e-08 | 128 |
hsa0414528 | Oral cavity | OSCC | Phagosome | 88/3704 | 152/8465 | 2.83e-04 | 9.13e-04 | 4.65e-04 | 88 |
hsa041516 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
hsa0516514 | Oral cavity | OSCC | Human papillomavirus infection | 200/3704 | 331/8465 | 3.83e-10 | 4.93e-09 | 2.51e-09 | 200 |
hsa04510110 | Oral cavity | OSCC | Focal adhesion | 128/3704 | 203/8465 | 1.71e-08 | 1.63e-07 | 8.31e-08 | 128 |
hsa04145113 | Oral cavity | OSCC | Phagosome | 88/3704 | 152/8465 | 2.83e-04 | 9.13e-04 | 4.65e-04 | 88 |
hsa0415113 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
hsa0414529 | Oral cavity | LP | Phagosome | 73/2418 | 152/8465 | 2.37e-07 | 3.29e-06 | 2.12e-06 | 73 |
hsa0516523 | Oral cavity | LP | Human papillomavirus infection | 121/2418 | 331/8465 | 8.00e-04 | 3.86e-03 | 2.49e-03 | 121 |
hsa0414536 | Oral cavity | LP | Phagosome | 73/2418 | 152/8465 | 2.37e-07 | 3.29e-06 | 2.12e-06 | 73 |
hsa0516533 | Oral cavity | LP | Human papillomavirus infection | 121/2418 | 331/8465 | 8.00e-04 | 3.86e-03 | 2.49e-03 | 121 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
THBS2 | SDC4 | THBS2_SDC4 | THBS | Breast | ADJ |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | ADJ |
THBS2 | SDC1 | THBS2_SDC1 | THBS | Breast | DCIS |
THBS2 | SDC4 | THBS2_SDC4 | THBS | Breast | DCIS |
THBS2 | CD36 | THBS2_CD36 | THBS | Breast | DCIS |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | DCIS |
THBS2 | SDC1 | THBS2_SDC1 | THBS | Breast | Healthy |
THBS2 | SDC4 | THBS2_SDC4 | THBS | Breast | Healthy |
THBS2 | CD36 | THBS2_CD36 | THBS | Breast | Healthy |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | Healthy |
THBS2 | SDC1 | THBS2_SDC1 | THBS | Breast | IDC |
THBS2 | SDC4 | THBS2_SDC4 | THBS | Breast | IDC |
THBS2 | CD36 | THBS2_CD36 | THBS | Breast | IDC |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | IDC |
THBS2 | SDC4 | THBS2_SDC4 | THBS | Breast | Precancer |
THBS2 | CD36 | THBS2_CD36 | THBS | Breast | Precancer |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | Precancer |
THBS2 | ITGA3_ITGB1 | THBS2_ITGA3_ITGB1 | THBS | Cervix | ADJ |
THBS2 | SDC1 | THBS2_SDC1 | THBS | Cervix | ADJ |
THBS2 | SDC4 | THBS2_SDC4 | THBS | Cervix | ADJ |
Page: 1 2 3 4 5 6 7 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
THBS2 | SNV | Missense_Mutation | c.906N>T | p.Gln302His | p.Q302H | P35442 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.45) | TCGA-97-7554-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | alimta | SD | |
THBS2 | SNV | Missense_Mutation | novel | c.2292G>T | p.Gln764His | p.Q764H | P35442 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-L9-A5IP-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
THBS2 | SNV | Missense_Mutation | novel | c.2047G>C | p.Gly683Arg | p.G683R | P35442 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MN-A4N5-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
THBS2 | SNV | Missense_Mutation | novel | c.873C>A | p.Ser291Arg | p.S291R | P35442 | protein_coding | tolerated(0.49) | benign(0) | TCGA-MP-A4T4-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
THBS2 | SNV | Missense_Mutation | novel | c.2219G>T | p.Cys740Phe | p.C740F | P35442 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
THBS2 | SNV | Missense_Mutation | novel | c.2074G>T | p.Gly692Trp | p.G692W | P35442 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NJ-A4YQ-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
THBS2 | SNV | Missense_Mutation | rs534679770 | c.418N>A | p.Glu140Lys | p.E140K | P35442 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
THBS2 | SNV | Missense_Mutation | c.140N>A | p.Gly47Glu | p.G47E | P35442 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
THBS2 | SNV | Missense_Mutation | c.3362N>C | p.Gly1121Ala | p.G1121A | P35442 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-18-3412-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | vinorelbine | PD | |
THBS2 | SNV | Missense_Mutation | c.1340C>A | p.Ser447Tyr | p.S447Y | P35442 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-21-5787-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7058 | THBS2 | DRUGGABLE GENOME | BEVACIZUMAB | BEVACIZUMAB | 16365183 | |
7058 | THBS2 | DRUGGABLE GENOME | ADRENOCORTICOTROPIC HORMONE | 8698834 |
Page: 1 |