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Gene: TET2 |
Gene summary for TET2 |
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Gene information | Species | Human | Gene symbol | TET2 | Gene ID | 54790 |
Gene name | tet methylcytosine dioxygenase 2 | |
Gene Alias | IMD75 | |
Cytomap | 4q24 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | A0A158SIU0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54790 | TET2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.09e-22 | -7.04e-01 | 0.0155 |
54790 | TET2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.79e-04 | -4.90e-01 | -0.1808 |
54790 | TET2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.32e-03 | -7.70e-01 | 0.0216 |
54790 | TET2 | HTA11_78_2000001011 | Human | Colorectum | AD | 5.20e-04 | -4.14e-01 | -0.1088 |
54790 | TET2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.78e-08 | -6.24e-01 | -0.1207 |
54790 | TET2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.07e-13 | -5.40e-01 | -0.1464 |
54790 | TET2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.35e-04 | -4.16e-01 | -0.1001 |
54790 | TET2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.74e-07 | -4.39e-01 | -0.059 |
54790 | TET2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.04e-02 | -6.68e-01 | -0.2061 |
54790 | TET2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.74e-02 | -5.33e-01 | -0.0179 |
54790 | TET2 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.23e-17 | -6.49e-01 | 0.096 |
54790 | TET2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.76e-04 | -7.20e-01 | 0.0528 |
54790 | TET2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.34e-09 | -6.26e-01 | 0.0338 |
54790 | TET2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.57e-16 | -6.00e-01 | 0.0674 |
54790 | TET2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.67e-13 | -4.65e-01 | 0.294 |
54790 | TET2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.03e-02 | -4.39e-01 | 0.281 |
54790 | TET2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.01e-22 | -6.62e-01 | 0.3859 |
54790 | TET2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.18e-10 | -7.73e-01 | 0.2585 |
54790 | TET2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.55e-28 | -7.33e-01 | 0.3005 |
54790 | TET2 | F007 | Human | Colorectum | FAP | 1.04e-02 | -3.27e-01 | 0.1176 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0044270 | Colorectum | AD | cellular nitrogen compound catabolic process | 147/3918 | 451/18723 | 3.35e-09 | 2.23e-07 | 147 |
GO:0046700 | Colorectum | AD | heterocycle catabolic process | 145/3918 | 445/18723 | 4.37e-09 | 2.84e-07 | 145 |
GO:0019439 | Colorectum | AD | aromatic compound catabolic process | 146/3918 | 467/18723 | 7.48e-08 | 3.84e-06 | 146 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0030099 | Colorectum | AD | myeloid cell differentiation | 119/3918 | 381/18723 | 1.24e-06 | 4.01e-05 | 119 |
GO:0006486 | Colorectum | AD | protein glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0043413 | Colorectum | AD | macromolecule glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0070085 | Colorectum | AD | glycosylation | 67/3918 | 240/18723 | 5.78e-03 | 3.67e-02 | 67 |
GO:00442701 | Colorectum | SER | cellular nitrogen compound catabolic process | 99/2897 | 451/18723 | 1.46e-04 | 2.86e-03 | 99 |
GO:00467001 | Colorectum | SER | heterocycle catabolic process | 97/2897 | 445/18723 | 2.20e-04 | 3.89e-03 | 97 |
GO:19013611 | Colorectum | SER | organic cyclic compound catabolic process | 104/2897 | 495/18723 | 5.46e-04 | 7.63e-03 | 104 |
GO:00194391 | Colorectum | SER | aromatic compound catabolic process | 98/2897 | 467/18723 | 8.09e-04 | 1.01e-02 | 98 |
GO:00300991 | Colorectum | SER | myeloid cell differentiation | 80/2897 | 381/18723 | 2.28e-03 | 2.18e-02 | 80 |
GO:00442702 | Colorectum | MSS | cellular nitrogen compound catabolic process | 141/3467 | 451/18723 | 2.95e-11 | 3.83e-09 | 141 |
GO:00467002 | Colorectum | MSS | heterocycle catabolic process | 139/3467 | 445/18723 | 4.37e-11 | 5.05e-09 | 139 |
GO:19013612 | Colorectum | MSS | organic cyclic compound catabolic process | 148/3467 | 495/18723 | 3.47e-10 | 3.18e-08 | 148 |
GO:00194392 | Colorectum | MSS | aromatic compound catabolic process | 140/3467 | 467/18723 | 8.56e-10 | 6.85e-08 | 140 |
GO:00300992 | Colorectum | MSS | myeloid cell differentiation | 110/3467 | 381/18723 | 4.48e-07 | 1.75e-05 | 110 |
GO:0016570 | Colorectum | MSS | histone modification | 113/3467 | 463/18723 | 8.37e-04 | 8.68e-03 | 113 |
GO:00442704 | Colorectum | FAP | cellular nitrogen compound catabolic process | 101/2622 | 451/18723 | 7.42e-07 | 3.44e-05 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TET2 | insertion | Frame_Shift_Ins | novel | c.3014dupA | p.Val1006GlyfsTer3 | p.V1006Gfs*3 | Q6N021 | protein_coding | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | ||
TET2 | insertion | Frame_Shift_Ins | novel | c.1786_1787insTCTTGCTCTTTGTT | p.Ser597LeufsTer9 | p.S597Lfs*9 | Q6N021 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
TET2 | insertion | In_Frame_Ins | novel | c.1890_1891insATC | p.Lys630_Ser631insIle | p.K630_S631insI | Q6N021 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
54790 | TET2 | CLINICALLY ACTIONABLE, ENZYME | Azacitidine | AZACITIDINE | 25224413,21494260 | |
54790 | TET2 | CLINICALLY ACTIONABLE, ENZYME | N/A | 24507812,23099237,24994606,26769228,24524305,25224413,25412851,19666869 | ||
54790 | TET2 | CLINICALLY ACTIONABLE, ENZYME | hydrochlorothiazide | HYDROCHLOROTHIAZIDE | ||
54790 | TET2 | CLINICALLY ACTIONABLE, ENZYME | Decitabine | DECITABINE | 25224413 |
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