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Gene: SCAF11 |
Gene summary for SCAF11 |
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Gene information | Species | Human | Gene symbol | SCAF11 | Gene ID | 9169 |
Gene name | SR-related CTD associated factor 11 | |
Gene Alias | CASP11 | |
Cytomap | 12q12 | |
Gene Type | protein-coding | GO ID | GO:0000245 | UniProtAcc | Q99590 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9169 | SCAF11 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.53e-09 | -4.08e-01 | 0.0155 |
9169 | SCAF11 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.97e-19 | 6.80e-01 | -0.1954 |
9169 | SCAF11 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.05e-07 | 1.10e+00 | 0.3487 |
9169 | SCAF11 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.97e-07 | 6.41e-01 | 0.281 |
9169 | SCAF11 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.26e-08 | -3.92e-01 | 0.3005 |
9169 | SCAF11 | A015-C-203 | Human | Colorectum | FAP | 4.10e-32 | -1.74e-01 | -0.1294 |
9169 | SCAF11 | A015-C-204 | Human | Colorectum | FAP | 3.12e-04 | -1.56e-02 | -0.0228 |
9169 | SCAF11 | A014-C-040 | Human | Colorectum | FAP | 3.58e-04 | -7.83e-02 | -0.1184 |
9169 | SCAF11 | A002-C-201 | Human | Colorectum | FAP | 7.88e-11 | -2.01e-01 | 0.0324 |
9169 | SCAF11 | A001-C-119 | Human | Colorectum | FAP | 4.60e-06 | 1.16e-01 | -0.1557 |
9169 | SCAF11 | A001-C-108 | Human | Colorectum | FAP | 2.20e-12 | 7.20e-02 | -0.0272 |
9169 | SCAF11 | A002-C-205 | Human | Colorectum | FAP | 2.66e-21 | -8.51e-02 | -0.1236 |
9169 | SCAF11 | A001-C-104 | Human | Colorectum | FAP | 1.36e-03 | 1.95e-02 | 0.0184 |
9169 | SCAF11 | A015-C-006 | Human | Colorectum | FAP | 7.63e-15 | 8.63e-03 | -0.0994 |
9169 | SCAF11 | A015-C-106 | Human | Colorectum | FAP | 4.37e-07 | -2.55e-02 | -0.0511 |
9169 | SCAF11 | A002-C-114 | Human | Colorectum | FAP | 4.16e-17 | -7.34e-02 | -0.1561 |
9169 | SCAF11 | A015-C-104 | Human | Colorectum | FAP | 7.11e-33 | -7.00e-02 | -0.1899 |
9169 | SCAF11 | A001-C-014 | Human | Colorectum | FAP | 2.30e-13 | -9.82e-03 | 0.0135 |
9169 | SCAF11 | A002-C-016 | Human | Colorectum | FAP | 1.07e-22 | -8.09e-02 | 0.0521 |
9169 | SCAF11 | A015-C-002 | Human | Colorectum | FAP | 1.33e-11 | 2.80e-02 | -0.0763 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:0022618 | Colorectum | AD | ribonucleoprotein complex assembly | 92/3918 | 220/18723 | 1.49e-12 | 2.60e-10 | 92 |
GO:0071826 | Colorectum | AD | ribonucleoprotein complex subunit organization | 94/3918 | 227/18723 | 1.70e-12 | 2.87e-10 | 94 |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:0000245 | Colorectum | AD | spliceosomal complex assembly | 33/3918 | 79/18723 | 2.15e-05 | 4.33e-04 | 33 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:00003772 | Colorectum | MSS | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003982 | Colorectum | MSS | mRNA splicing, via spliceosome | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003752 | Colorectum | MSS | RNA splicing, via transesterification reactions | 122/3467 | 324/18723 | 2.75e-16 | 8.58e-14 | 122 |
GO:00718262 | Colorectum | MSS | ribonucleoprotein complex subunit organization | 90/3467 | 227/18723 | 6.88e-14 | 1.78e-11 | 90 |
GO:00226182 | Colorectum | MSS | ribonucleoprotein complex assembly | 88/3467 | 220/18723 | 7.12e-14 | 1.78e-11 | 88 |
GO:00226132 | Colorectum | MSS | ribonucleoprotein complex biogenesis | 144/3467 | 463/18723 | 2.76e-11 | 3.67e-09 | 144 |
GO:00002451 | Colorectum | MSS | spliceosomal complex assembly | 31/3467 | 79/18723 | 1.33e-05 | 3.07e-04 | 31 |
GO:00226183 | Colorectum | MSI-H | ribonucleoprotein complex assembly | 62/1319 | 220/18723 | 7.13e-22 | 8.32e-19 | 62 |
GO:00718263 | Colorectum | MSI-H | ribonucleoprotein complex subunit organization | 63/1319 | 227/18723 | 8.08e-22 | 8.32e-19 | 63 |
GO:00226133 | Colorectum | MSI-H | ribonucleoprotein complex biogenesis | 95/1319 | 463/18723 | 1.04e-21 | 8.32e-19 | 95 |
GO:00083803 | Colorectum | MSI-H | RNA splicing | 82/1319 | 434/18723 | 1.22e-16 | 4.53e-14 | 82 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCAF11 | SNV | Missense_Mutation | c.4055N>T | p.Ala1352Val | p.A1352V | Q99590 | protein_coding | deleterious(0.05) | possibly_damaging(0.813) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SCAF11 | SNV | Missense_Mutation | c.3158N>G | p.Glu1053Gly | p.E1053G | Q99590 | protein_coding | tolerated(0.09) | benign(0.072) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SCAF11 | SNV | Missense_Mutation | c.1895N>C | p.Val632Ala | p.V632A | Q99590 | protein_coding | tolerated(0.37) | benign(0.005) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SCAF11 | SNV | Missense_Mutation | c.619N>C | p.Tyr207His | p.Y207H | Q99590 | protein_coding | tolerated(0.55) | benign(0) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SCAF11 | SNV | Missense_Mutation | c.683G>T | p.Arg228Ile | p.R228I | Q99590 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
SCAF11 | SNV | Missense_Mutation | c.217G>A | p.Glu73Lys | p.E73K | Q99590 | protein_coding | tolerated(0.13) | possibly_damaging(0.771) | TCGA-CD-8535-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | docetaxel | CR | |
SCAF11 | SNV | Missense_Mutation | c.1390T>C | p.Tyr464His | p.Y464H | Q99590 | protein_coding | tolerated(1) | benign(0) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SCAF11 | SNV | Missense_Mutation | c.1177N>C | p.Ser393Pro | p.S393P | Q99590 | protein_coding | deleterious(0.02) | probably_damaging(0.982) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SCAF11 | SNV | Missense_Mutation | c.3941N>C | p.Met1314Thr | p.M1314T | Q99590 | protein_coding | tolerated(0.17) | benign(0.007) | TCGA-F1-A448-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | CR | |
SCAF11 | SNV | Missense_Mutation | novel | c.973N>T | p.Arg325Cys | p.R325C | Q99590 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-HU-8244-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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