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Gene: PRKD1 |
Gene summary for PRKD1 |
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Gene information | Species | Human | Gene symbol | PRKD1 | Gene ID | 5587 |
Gene name | protein kinase D1 | |
Gene Alias | CHDED | |
Cytomap | 14q12 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | F8WBA3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5587 | PRKD1 | AEH-subject1 | Human | Endometrium | AEH | 3.01e-12 | 3.58e-01 | -0.3059 |
5587 | PRKD1 | AEH-subject4 | Human | Endometrium | AEH | 2.72e-03 | 3.02e-01 | -0.2657 |
5587 | PRKD1 | AEH-subject5 | Human | Endometrium | AEH | 5.98e-04 | 2.86e-01 | -0.2953 |
5587 | PRKD1 | EEC-subject1 | Human | Endometrium | EEC | 1.75e-03 | 2.70e-01 | -0.2682 |
5587 | PRKD1 | RNA-P17T-P17T-2 | Human | Lung | IAC | 5.18e-04 | 6.70e-01 | 0.3371 |
5587 | PRKD1 | RNA-P17T-P17T-4 | Human | Lung | IAC | 7.57e-03 | 6.29e-01 | 0.343 |
5587 | PRKD1 | RNA-P17T-P17T-6 | Human | Lung | IAC | 4.91e-03 | 6.04e-01 | 0.3385 |
5587 | PRKD1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 4.47e-19 | 8.93e-01 | -0.2116 |
5587 | PRKD1 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 1.25e-07 | 8.28e-01 | -0.1941 |
5587 | PRKD1 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 2.19e-08 | 8.45e-01 | -0.2107 |
5587 | PRKD1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 6.51e-18 | 9.13e-01 | -0.2119 |
5587 | PRKD1 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 9.18e-03 | 5.86e-01 | -0.0961 |
5587 | PRKD1 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 7.80e-07 | 6.31e-01 | -0.0876 |
5587 | PRKD1 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 2.76e-06 | 7.19e-01 | -0.0822 |
5587 | PRKD1 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 2.18e-07 | 6.32e-01 | -0.0809 |
5587 | PRKD1 | RNA-P8T2-P8T2-3 | Human | Lung | AIS | 1.91e-04 | 8.96e-01 | -0.1284 |
5587 | PRKD1 | HTA12-15-2 | Human | Pancreas | PDAC | 4.41e-04 | 3.11e-01 | 0.2315 |
5587 | PRKD1 | HTA12-25-1 | Human | Pancreas | PDAC | 3.33e-07 | 5.55e-01 | 0.313 |
5587 | PRKD1 | HTA12-26-1 | Human | Pancreas | PDAC | 4.88e-07 | 4.50e-01 | 0.3728 |
5587 | PRKD1 | HTA12-29-1 | Human | Pancreas | PDAC | 1.02e-28 | 6.89e-01 | 0.3722 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003164716 | Endometrium | AEH | regulation of protein stability | 77/2100 | 298/18723 | 1.13e-12 | 2.26e-10 | 77 |
GO:000989616 | Endometrium | AEH | positive regulation of catabolic process | 104/2100 | 492/18723 | 9.38e-11 | 1.10e-08 | 104 |
GO:190495115 | Endometrium | AEH | positive regulation of establishment of protein localization | 74/2100 | 319/18723 | 7.05e-10 | 6.51e-08 | 74 |
GO:003133116 | Endometrium | AEH | positive regulation of cellular catabolic process | 91/2100 | 427/18723 | 9.15e-10 | 8.31e-08 | 91 |
GO:190382916 | Endometrium | AEH | positive regulation of cellular protein localization | 66/2100 | 276/18723 | 1.57e-09 | 1.36e-07 | 66 |
GO:000697916 | Endometrium | AEH | response to oxidative stress | 93/2100 | 446/18723 | 1.94e-09 | 1.64e-07 | 93 |
GO:007259410 | Endometrium | AEH | establishment of protein localization to organelle | 89/2100 | 422/18723 | 2.41e-09 | 1.90e-07 | 89 |
GO:005122215 | Endometrium | AEH | positive regulation of protein transport | 66/2100 | 303/18723 | 7.79e-08 | 3.99e-06 | 66 |
GO:006219716 | Endometrium | AEH | cellular response to chemical stress | 71/2100 | 337/18723 | 1.03e-07 | 5.05e-06 | 71 |
GO:00072296 | Endometrium | AEH | integrin-mediated signaling pathway | 32/2100 | 107/18723 | 1.24e-07 | 5.80e-06 | 32 |
GO:000166710 | Endometrium | AEH | ameboidal-type cell migration | 90/2100 | 475/18723 | 3.73e-07 | 1.57e-05 | 90 |
GO:00016498 | Endometrium | AEH | osteoblast differentiation | 52/2100 | 229/18723 | 4.74e-07 | 1.92e-05 | 52 |
GO:00506738 | Endometrium | AEH | epithelial cell proliferation | 84/2100 | 437/18723 | 4.88e-07 | 1.94e-05 | 84 |
GO:009013014 | Endometrium | AEH | tissue migration | 73/2100 | 365/18723 | 5.79e-07 | 2.20e-05 | 73 |
GO:009013214 | Endometrium | AEH | epithelium migration | 72/2100 | 360/18723 | 6.90e-07 | 2.55e-05 | 72 |
GO:001063114 | Endometrium | AEH | epithelial cell migration | 71/2100 | 357/18723 | 1.02e-06 | 3.52e-05 | 71 |
GO:003315710 | Endometrium | AEH | regulation of intracellular protein transport | 51/2100 | 229/18723 | 1.13e-06 | 3.75e-05 | 51 |
GO:00015038 | Endometrium | AEH | ossification | 78/2100 | 408/18723 | 1.54e-06 | 4.85e-05 | 78 |
GO:003238810 | Endometrium | AEH | positive regulation of intracellular transport | 46/2100 | 202/18723 | 1.96e-06 | 5.93e-05 | 46 |
GO:001063214 | Endometrium | AEH | regulation of epithelial cell migration | 60/2100 | 292/18723 | 2.31e-06 | 6.77e-05 | 60 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520826 | Endometrium | AEH | Chemical carcinogenesis - reactive oxygen species | 91/1197 | 223/8465 | 3.28e-23 | 1.33e-21 | 9.76e-22 | 91 |
hsa0401514 | Endometrium | AEH | Rap1 signaling pathway | 49/1197 | 210/8465 | 2.03e-04 | 1.78e-03 | 1.30e-03 | 49 |
hsa05208112 | Endometrium | AEH | Chemical carcinogenesis - reactive oxygen species | 91/1197 | 223/8465 | 3.28e-23 | 1.33e-21 | 9.76e-22 | 91 |
hsa0401515 | Endometrium | AEH | Rap1 signaling pathway | 49/1197 | 210/8465 | 2.03e-04 | 1.78e-03 | 1.30e-03 | 49 |
hsa0520827 | Endometrium | EEC | Chemical carcinogenesis - reactive oxygen species | 94/1237 | 223/8465 | 4.11e-24 | 1.93e-22 | 1.44e-22 | 94 |
hsa0401522 | Endometrium | EEC | Rap1 signaling pathway | 49/1237 | 210/8465 | 4.45e-04 | 3.47e-03 | 2.59e-03 | 49 |
hsa0520836 | Endometrium | EEC | Chemical carcinogenesis - reactive oxygen species | 94/1237 | 223/8465 | 4.11e-24 | 1.93e-22 | 1.44e-22 | 94 |
hsa0401532 | Endometrium | EEC | Rap1 signaling pathway | 49/1237 | 210/8465 | 4.45e-04 | 3.47e-03 | 2.59e-03 | 49 |
hsa0520816 | Lung | IAC | Chemical carcinogenesis - reactive oxygen species | 51/1053 | 223/8465 | 8.45e-06 | 2.14e-04 | 1.42e-04 | 51 |
hsa0401510 | Lung | IAC | Rap1 signaling pathway | 41/1053 | 210/8465 | 2.01e-03 | 1.07e-02 | 7.10e-03 | 41 |
hsa0520817 | Lung | IAC | Chemical carcinogenesis - reactive oxygen species | 51/1053 | 223/8465 | 8.45e-06 | 2.14e-04 | 1.42e-04 | 51 |
hsa0401511 | Lung | IAC | Rap1 signaling pathway | 41/1053 | 210/8465 | 2.01e-03 | 1.07e-02 | 7.10e-03 | 41 |
hsa0520823 | Lung | AIS | Chemical carcinogenesis - reactive oxygen species | 47/961 | 223/8465 | 1.63e-05 | 3.77e-04 | 2.41e-04 | 47 |
hsa0401521 | Lung | AIS | Rap1 signaling pathway | 41/961 | 210/8465 | 3.23e-04 | 3.38e-03 | 2.16e-03 | 41 |
hsa0520833 | Lung | AIS | Chemical carcinogenesis - reactive oxygen species | 47/961 | 223/8465 | 1.63e-05 | 3.77e-04 | 2.41e-04 | 47 |
hsa0401531 | Lung | AIS | Rap1 signaling pathway | 41/961 | 210/8465 | 3.23e-04 | 3.38e-03 | 2.16e-03 | 41 |
hsa0520828 | Prostate | BPH | Chemical carcinogenesis - reactive oxygen species | 114/1718 | 223/8465 | 3.05e-25 | 1.44e-23 | 8.91e-24 | 114 |
hsa0401516 | Prostate | BPH | Rap1 signaling pathway | 61/1718 | 210/8465 | 1.40e-03 | 5.85e-03 | 3.62e-03 | 61 |
hsa05208113 | Prostate | BPH | Chemical carcinogenesis - reactive oxygen species | 114/1718 | 223/8465 | 3.05e-25 | 1.44e-23 | 8.91e-24 | 114 |
hsa0401517 | Prostate | BPH | Rap1 signaling pathway | 61/1718 | 210/8465 | 1.40e-03 | 5.85e-03 | 3.62e-03 | 61 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRKD1 | SNV | Missense_Mutation | c.991G>A | p.Glu331Lys | p.E331K | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | ||
PRKD1 | SNV | Missense_Mutation | c.880N>C | p.Tyr294His | p.Y294H | protein_coding | tolerated(0.64) | benign(0.007) | TCGA-BR-A4QL-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | CR | ||
PRKD1 | SNV | Missense_Mutation | c.526A>C | p.Lys176Gln | p.K176Q | protein_coding | deleterious(0.04) | probably_damaging(0.956) | TCGA-BR-A4QM-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD | ||
PRKD1 | SNV | Missense_Mutation | c.2686N>C | p.Ser896Arg | p.S896R | protein_coding | tolerated_low_confidence(0.52) | benign(0.091) | TCGA-CD-8534-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
PRKD1 | SNV | Missense_Mutation | c.2686N>C | p.Ser896Arg | p.S896R | protein_coding | tolerated_low_confidence(0.52) | benign(0.091) | TCGA-CD-8535-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | docetaxel | CR | ||
PRKD1 | SNV | Missense_Mutation | rs373748041 | c.434N>A | p.Arg145His | p.R145H | protein_coding | tolerated(0.06) | possibly_damaging(0.585) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
PRKD1 | SNV | Missense_Mutation | c.1579N>A | p.Val527Ile | p.V527I | protein_coding | tolerated(0.44) | benign(0) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD | ||
PRKD1 | SNV | Missense_Mutation | c.2402T>C | p.Ile801Thr | p.I801T | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
PRKD1 | SNV | Missense_Mutation | rs780784905 | c.409G>A | p.Ala137Thr | p.A137T | protein_coding | tolerated(0.06) | possibly_damaging(0.476) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PRKD1 | SNV | Missense_Mutation | c.2159N>G | p.Val720Gly | p.V720G | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | 178102596 | ||
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | SOPHORETIN | QUERCETIN | |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | 249565728 | ||
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | 328083472 | ||
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | RESVERATROL | RESVERATROL | 11008129 | |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | CHEMBL494089 | GSK-690693 | |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | 348353640 | ||
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | VASOPRESSIN | VASOPRESSIN | 11514571 | |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | CHEMBL608533 | MIDOSTAURIN | |
5587 | PRKD1 | DRUGGABLE GENOME, KINASE, ENZYME, TRANSCRIPTION FACTOR, SERINE THREONINE KINASE | inhibitor | 328083471 |
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