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Gene: PDZRN4 |
Gene summary for PDZRN4 |
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Gene information | Species | Human | Gene symbol | PDZRN4 | Gene ID | 29951 |
Gene name | PDZ domain containing ring finger 4 | |
Gene Alias | LNX4 | |
Cytomap | 12q12 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | B4DGD1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29951 | PDZRN4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.88e-04 | 1.77e-01 | 0.0155 |
29951 | PDZRN4 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.59e-03 | 1.74e-01 | -0.1954 |
29951 | PDZRN4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.27e-03 | 1.61e-01 | -0.1207 |
29951 | PDZRN4 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.66e-04 | 1.46e-01 | -0.1464 |
29951 | PDZRN4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.94e-04 | 2.35e-01 | -0.059 |
29951 | PDZRN4 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.25e-03 | 3.90e-01 | -0.1706 |
29951 | PDZRN4 | HTA11_546_2000001011 | Human | Colorectum | AD | 7.42e-04 | 2.15e-01 | -0.0842 |
29951 | PDZRN4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.33e-82 | 3.95e+00 | 0.281 |
29951 | PDZRN4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.21e-19 | 5.26e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDZRN4 | SNV | Missense_Mutation | novel | c.2062N>T | p.Arg688Trp | p.R688W | Q6ZMN7 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-98-8022-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PDZRN4 | SNV | Missense_Mutation | novel | c.2689G>T | p.Gly897Trp | p.G897W | Q6ZMN7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NC-A5HE-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
PDZRN4 | SNV | Missense_Mutation | novel | c.2690G>T | p.Gly897Val | p.G897V | Q6ZMN7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NC-A5HE-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
PDZRN4 | SNV | Missense_Mutation | novel | c.1244N>A | p.Gly415Asp | p.G415D | Q6ZMN7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NC-A5HO-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | CR |
PDZRN4 | SNV | Missense_Mutation | novel | c.854N>G | p.Lys285Arg | p.K285R | Q6ZMN7 | protein_coding | tolerated(0.26) | benign(0.01) | TCGA-NC-A5HP-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD |
PDZRN4 | insertion | Frame_Shift_Ins | novel | c.1302_1302+1insAAAATCTGCAACA | p.Val435LysfsTer6 | p.V435Kfs*6 | Q6ZMN7 | protein_coding | TCGA-86-A4D0-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR | ||
PDZRN4 | deletion | Frame_Shift_Del | novel | c.1587delN | p.Lys531SerfsTer25 | p.K531Sfs*25 | Q6ZMN7 | protein_coding | TCGA-63-A5MW-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
PDZRN4 | SNV | Missense_Mutation | novel | c.2029N>A | p.Glu677Lys | p.E677K | Q6ZMN7 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-BA-6870-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
PDZRN4 | SNV | Missense_Mutation | novel | c.2539G>C | p.Ala847Pro | p.A847P | Q6ZMN7 | protein_coding | deleterious(0.05) | probably_damaging(0.979) | TCGA-BA-A6DA-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PDZRN4 | SNV | Missense_Mutation | rs868597327 | c.2207N>T | p.Ser736Phe | p.S736F | Q6ZMN7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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