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Gene: NLRP8 |
Gene summary for NLRP8 |
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Gene information | Species | Human | Gene symbol | NLRP8 | Gene ID | 126205 |
Gene name | NLR family pyrin domain containing 8 | |
Gene Alias | CLR19.2 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q86W28 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
126205 | NLRP8 | HCC1 | Human | Liver | HCC | 3.12e-03 | 2.91e-01 | 0.5336 |
126205 | NLRP8 | HCC2 | Human | Liver | HCC | 8.19e-10 | 5.04e-01 | 0.5341 |
126205 | NLRP8 | HCC5 | Human | Liver | HCC | 5.72e-12 | 5.53e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NLRP8 | SNV | Missense_Mutation | novel | c.2085N>C | p.Leu695Phe | p.L695F | Q86W28 | protein_coding | tolerated(0.41) | benign(0.034) | TCGA-DQ-5629-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
NLRP8 | SNV | Missense_Mutation | novel | c.243G>T | p.Trp81Cys | p.W81C | Q86W28 | protein_coding | tolerated(0.15) | benign(0.063) | TCGA-F7-7848-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NLRP8 | SNV | Missense_Mutation | novel | c.1147N>C | p.Ala383Pro | p.A383P | Q86W28 | protein_coding | tolerated(0.07) | possibly_damaging(0.76) | TCGA-IQ-A61H-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NLRP8 | SNV | Missense_Mutation | rs759351908 | c.1282N>A | p.Val428Ile | p.V428I | Q86W28 | protein_coding | tolerated(0.28) | benign(0.177) | TCGA-P3-A6T7-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
NLRP8 | SNV | Missense_Mutation | novel | c.740A>G | p.Glu247Gly | p.E247G | Q86W28 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-P3-A6T8-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
NLRP8 | SNV | Missense_Mutation | novel | c.619N>A | p.Ala207Thr | p.A207T | Q86W28 | protein_coding | deleterious(0.01) | benign(0.003) | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NLRP8 | SNV | Missense_Mutation | rs149738419 | c.272N>A | p.Arg91His | p.R91H | Q86W28 | protein_coding | tolerated(0.33) | benign(0) | TCGA-RS-A6TP-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NLRP8 | SNV | Missense_Mutation | rs199475833 | c.284G>A | p.Arg95Gln | p.R95Q | Q86W28 | protein_coding | tolerated(0.22) | benign(0.058) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
NLRP8 | SNV | Missense_Mutation | rs779904625 | c.451C>T | p.Arg151Trp | p.R151W | Q86W28 | protein_coding | deleterious(0.01) | benign(0) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
NLRP8 | SNV | Missense_Mutation | rs755334461 | c.1544C>T | p.Ala515Val | p.A515V | Q86W28 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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