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Gene: MAST2 |
Gene summary for MAST2 |
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Gene information | Species | Human | Gene symbol | MAST2 | Gene ID | 23139 |
Gene name | microtubule associated serine/threonine kinase 2 | |
Gene Alias | MAST205 | |
Cytomap | 1p34.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q6P0Q8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23139 | MAST2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.38e-17 | -6.27e-01 | 0.0155 |
23139 | MAST2 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.58e-06 | 5.60e-01 | -0.1954 |
23139 | MAST2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.03e-03 | 5.85e-01 | -0.1526 |
23139 | MAST2 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.29e-11 | -5.77e-01 | 0.096 |
23139 | MAST2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.36e-10 | -5.24e-01 | 0.0674 |
23139 | MAST2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.09e-04 | -5.58e-01 | 0.0588 |
23139 | MAST2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.47e-20 | -6.15e-01 | 0.294 |
23139 | MAST2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.02e-18 | -6.06e-01 | 0.3005 |
23139 | MAST2 | F007 | Human | Colorectum | FAP | 1.90e-05 | -4.71e-01 | 0.1176 |
23139 | MAST2 | A002-C-010 | Human | Colorectum | FAP | 2.81e-06 | -3.76e-01 | 0.242 |
23139 | MAST2 | A001-C-207 | Human | Colorectum | FAP | 3.97e-04 | -2.58e-01 | 0.1278 |
23139 | MAST2 | A015-C-203 | Human | Colorectum | FAP | 1.09e-28 | -4.50e-01 | -0.1294 |
23139 | MAST2 | A015-C-204 | Human | Colorectum | FAP | 3.06e-09 | -3.49e-01 | -0.0228 |
23139 | MAST2 | A014-C-040 | Human | Colorectum | FAP | 2.68e-07 | -6.08e-01 | -0.1184 |
23139 | MAST2 | A002-C-201 | Human | Colorectum | FAP | 5.70e-17 | -4.48e-01 | 0.0324 |
23139 | MAST2 | A002-C-203 | Human | Colorectum | FAP | 8.18e-04 | -2.97e-01 | 0.2786 |
23139 | MAST2 | A001-C-119 | Human | Colorectum | FAP | 1.63e-08 | -4.14e-01 | -0.1557 |
23139 | MAST2 | A001-C-108 | Human | Colorectum | FAP | 1.87e-23 | -4.35e-01 | -0.0272 |
23139 | MAST2 | A002-C-205 | Human | Colorectum | FAP | 1.11e-24 | -5.31e-01 | -0.1236 |
23139 | MAST2 | A001-C-104 | Human | Colorectum | FAP | 3.91e-05 | -3.51e-01 | 0.0184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0018105 | Colorectum | AD | peptidyl-serine phosphorylation | 88/3918 | 315/18723 | 1.73e-03 | 1.43e-02 | 88 |
GO:0018209 | Colorectum | AD | peptidyl-serine modification | 92/3918 | 338/18723 | 3.19e-03 | 2.36e-02 | 92 |
GO:00181051 | Colorectum | SER | peptidyl-serine phosphorylation | 66/2897 | 315/18723 | 5.47e-03 | 4.06e-02 | 66 |
GO:00181052 | Colorectum | MSS | peptidyl-serine phosphorylation | 81/3467 | 315/18723 | 8.92e-04 | 9.12e-03 | 81 |
GO:00182091 | Colorectum | MSS | peptidyl-serine modification | 84/3467 | 338/18723 | 2.12e-03 | 1.79e-02 | 84 |
GO:00181053 | Colorectum | FAP | peptidyl-serine phosphorylation | 71/2622 | 315/18723 | 2.51e-05 | 5.82e-04 | 71 |
GO:00182092 | Colorectum | FAP | peptidyl-serine modification | 73/2622 | 338/18723 | 8.47e-05 | 1.51e-03 | 73 |
GO:00181054 | Colorectum | CRC | peptidyl-serine phosphorylation | 61/2078 | 315/18723 | 9.88e-06 | 3.31e-04 | 61 |
GO:00182093 | Colorectum | CRC | peptidyl-serine modification | 62/2078 | 338/18723 | 4.67e-05 | 1.10e-03 | 62 |
GO:00182099 | Esophagus | ESCC | peptidyl-serine modification | 196/8552 | 338/18723 | 3.07e-06 | 3.47e-05 | 196 |
GO:001810515 | Esophagus | ESCC | peptidyl-serine phosphorylation | 184/8552 | 315/18723 | 3.22e-06 | 3.61e-05 | 184 |
GO:00181055 | Liver | NAFLD | peptidyl-serine phosphorylation | 63/1882 | 315/18723 | 7.45e-08 | 6.60e-06 | 63 |
GO:00182094 | Liver | NAFLD | peptidyl-serine modification | 64/1882 | 338/18723 | 4.65e-07 | 2.89e-05 | 64 |
GO:001810511 | Liver | HCC | peptidyl-serine phosphorylation | 169/7958 | 315/18723 | 3.86e-05 | 3.81e-04 | 169 |
GO:001820911 | Liver | HCC | peptidyl-serine modification | 177/7958 | 338/18723 | 1.45e-04 | 1.17e-03 | 177 |
GO:00181056 | Lung | IAC | peptidyl-serine phosphorylation | 69/2061 | 315/18723 | 1.48e-08 | 1.87e-06 | 69 |
GO:00182095 | Lung | IAC | peptidyl-serine modification | 70/2061 | 338/18723 | 1.23e-07 | 1.10e-05 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAST2 | insertion | Frame_Shift_Ins | novel | c.2171_2172insT | p.Gly727TrpfsTer14 | p.G727Wfs*14 | Q6P0Q8 | protein_coding | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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