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Gene: HFM1 |
Gene summary for HFM1 |
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Gene information | Species | Human | Gene symbol | HFM1 | Gene ID | 164045 |
Gene name | helicase for meiosis 1 | |
Gene Alias | MER3 | |
Cytomap | 1p22.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A2PYH4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
164045 | HFM1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.45e-05 | 2.00e-01 | 0.0155 |
164045 | HFM1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.26e-17 | 5.40e-01 | -0.1808 |
164045 | HFM1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.01e-08 | 9.04e-01 | 0.0216 |
164045 | HFM1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.15e-13 | 7.32e-01 | -0.0811 |
164045 | HFM1 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.43e-12 | 3.38e-01 | -0.1088 |
164045 | HFM1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.48e-33 | 6.14e-01 | -0.1954 |
164045 | HFM1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.83e-04 | 3.96e-01 | -0.2602 |
164045 | HFM1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.35e-10 | 8.74e-01 | -0.2196 |
164045 | HFM1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.53e-16 | 5.38e-01 | -0.1207 |
164045 | HFM1 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.55e-13 | 5.24e-01 | -0.1526 |
164045 | HFM1 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.32e-21 | 4.69e-01 | -0.1464 |
164045 | HFM1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.14e-46 | 9.64e-01 | -0.1001 |
164045 | HFM1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.90e-33 | 8.84e-01 | -0.059 |
164045 | HFM1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.07e-21 | 9.63e-01 | -0.1706 |
164045 | HFM1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.40e-05 | 3.55e-01 | -0.2061 |
164045 | HFM1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.64e-18 | 8.85e-01 | -0.1462 |
164045 | HFM1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.76e-10 | 4.07e-01 | -0.0842 |
164045 | HFM1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.89e-04 | 3.96e-01 | -0.00410000000000005 |
164045 | HFM1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.61e-02 | 2.62e-01 | -0.0179 |
164045 | HFM1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.40e-18 | 5.33e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032392 | Colorectum | AD | DNA geometric change | 31/3918 | 90/18723 | 2.02e-03 | 1.63e-02 | 31 |
GO:00323921 | Colorectum | MSS | DNA geometric change | 29/3467 | 90/18723 | 1.26e-03 | 1.20e-02 | 29 |
GO:0032508 | Colorectum | MSS | DNA duplex unwinding | 25/3467 | 84/18723 | 8.27e-03 | 4.99e-02 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HFM1 | SNV | Missense_Mutation | c.2687C>T | p.Ser896Leu | p.S896L | A2PYH4 | protein_coding | deleterious(0.02) | benign(0.406) | TCGA-NJ-A55O-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HFM1 | SNV | Missense_Mutation | novel | c.1847T>C | p.Leu616Ser | p.L616S | A2PYH4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
HFM1 | SNV | Missense_Mutation | c.1138C>A | p.His380Asn | p.H380N | A2PYH4 | protein_coding | tolerated(0.31) | benign(0.022) | TCGA-22-4599-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HFM1 | SNV | Missense_Mutation | c.1936A>T | p.Thr646Ser | p.T646S | A2PYH4 | protein_coding | tolerated(0.2) | benign(0.153) | TCGA-22-4607-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HFM1 | SNV | Missense_Mutation | c.2146N>C | p.Val716Leu | p.V716L | A2PYH4 | protein_coding | tolerated(1) | benign(0) | TCGA-22-5473-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
HFM1 | SNV | Missense_Mutation | c.3359N>T | p.Ser1120Leu | p.S1120L | A2PYH4 | protein_coding | tolerated(0.11) | benign(0.075) | TCGA-37-3789-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HFM1 | SNV | Missense_Mutation | novel | c.1273C>G | p.Leu425Val | p.L425V | A2PYH4 | protein_coding | deleterious(0.04) | probably_damaging(0.93) | TCGA-37-A5EL-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | temodal | PD |
HFM1 | SNV | Missense_Mutation | novel | c.3931N>T | p.Leu1311Phe | p.L1311F | A2PYH4 | protein_coding | tolerated_low_confidence(0.96) | benign(0) | TCGA-56-7222-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
HFM1 | SNV | Missense_Mutation | novel | c.3793N>A | p.Glu1265Lys | p.E1265K | A2PYH4 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.836) | TCGA-60-2696-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HFM1 | SNV | Missense_Mutation | c.3271N>G | p.Thr1091Ala | p.T1091A | A2PYH4 | protein_coding | tolerated(0.13) | benign(0.053) | TCGA-60-2724-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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