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Gene: GNAS |
Gene summary for GNAS |
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Gene information | Species | Human | Gene symbol | GNAS | Gene ID | 2778 |
Gene name | GNAS complex locus | |
Gene Alias | AHO | |
Cytomap | 20q13.32 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | A0A0S2Z3H8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2778 | GNAS | GSM4909286 | Human | Breast | IDC | 6.71e-08 | -1.78e-01 | 0.1081 |
2778 | GNAS | GSM4909293 | Human | Breast | IDC | 2.50e-09 | 3.32e-01 | 0.1581 |
2778 | GNAS | GSM4909294 | Human | Breast | IDC | 4.70e-06 | -7.31e-02 | 0.2022 |
2778 | GNAS | GSM4909296 | Human | Breast | IDC | 1.66e-07 | 2.08e-02 | 0.1524 |
2778 | GNAS | GSM4909297 | Human | Breast | IDC | 3.87e-19 | -4.92e-01 | 0.1517 |
2778 | GNAS | GSM4909303 | Human | Breast | IDC | 1.60e-05 | 5.04e-01 | 0.0438 |
2778 | GNAS | GSM4909304 | Human | Breast | IDC | 6.31e-33 | 5.16e-01 | 0.1636 |
2778 | GNAS | GSM4909306 | Human | Breast | IDC | 1.30e-07 | -4.55e-01 | 0.1564 |
2778 | GNAS | GSM4909308 | Human | Breast | IDC | 6.55e-04 | -1.31e-01 | 0.158 |
2778 | GNAS | GSM4909311 | Human | Breast | IDC | 4.01e-46 | -4.84e-01 | 0.1534 |
2778 | GNAS | GSM4909312 | Human | Breast | IDC | 5.09e-14 | -4.55e-01 | 0.1552 |
2778 | GNAS | GSM4909313 | Human | Breast | IDC | 2.95e-02 | -2.66e-01 | 0.0391 |
2778 | GNAS | GSM4909316 | Human | Breast | IDC | 2.82e-03 | 2.20e-01 | 0.21 |
2778 | GNAS | GSM4909317 | Human | Breast | IDC | 2.69e-04 | 3.24e-01 | 0.1355 |
2778 | GNAS | GSM4909318 | Human | Breast | IDC | 1.61e-04 | 3.66e-01 | 0.2031 |
2778 | GNAS | GSM4909319 | Human | Breast | IDC | 4.03e-52 | -4.26e-01 | 0.1563 |
2778 | GNAS | GSM4909320 | Human | Breast | IDC | 1.39e-05 | -3.56e-01 | 0.1575 |
2778 | GNAS | GSM4909321 | Human | Breast | IDC | 1.74e-10 | -2.31e-01 | 0.1559 |
2778 | GNAS | brca3 | Human | Breast | Precancer | 8.88e-06 | -1.39e-01 | -0.0263 |
2778 | GNAS | M2 | Human | Breast | IDC | 3.36e-33 | 9.39e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00341099 | Breast | Precancer | homotypic cell-cell adhesion | 18/1080 | 90/18723 | 3.15e-06 | 1.03e-04 | 18 |
GO:00420609 | Breast | Precancer | wound healing | 48/1080 | 422/18723 | 5.48e-06 | 1.63e-04 | 48 |
GO:00508789 | Breast | Precancer | regulation of body fluid levels | 40/1080 | 379/18723 | 1.68e-04 | 2.77e-03 | 40 |
GO:00705278 | Breast | Precancer | platelet aggregation | 12/1080 | 67/18723 | 4.02e-04 | 5.43e-03 | 12 |
GO:00075995 | Breast | Precancer | hemostasis | 24/1080 | 222/18723 | 2.31e-03 | 2.15e-02 | 24 |
GO:00075965 | Breast | Precancer | blood coagulation | 23/1080 | 217/18723 | 3.61e-03 | 2.98e-02 | 23 |
GO:00508175 | Breast | Precancer | coagulation | 23/1080 | 222/18723 | 4.78e-03 | 3.64e-02 | 23 |
GO:0030168 | Breast | Precancer | platelet activation | 15/1080 | 123/18723 | 4.80e-03 | 3.64e-02 | 15 |
GO:003410913 | Breast | IDC | homotypic cell-cell adhesion | 20/1434 | 90/18723 | 1.20e-05 | 3.17e-04 | 20 |
GO:004206014 | Breast | IDC | wound healing | 55/1434 | 422/18723 | 7.27e-05 | 1.45e-03 | 55 |
GO:005087813 | Breast | IDC | regulation of body fluid levels | 50/1434 | 379/18723 | 1.12e-04 | 2.10e-03 | 50 |
GO:007052713 | Breast | IDC | platelet aggregation | 12/1434 | 67/18723 | 4.53e-03 | 3.49e-02 | 12 |
GO:005087823 | Breast | DCIS | regulation of body fluid levels | 50/1390 | 379/18723 | 5.17e-05 | 1.06e-03 | 50 |
GO:004206024 | Breast | DCIS | wound healing | 54/1390 | 422/18723 | 6.09e-05 | 1.22e-03 | 54 |
GO:003410923 | Breast | DCIS | homotypic cell-cell adhesion | 18/1390 | 90/18723 | 9.33e-05 | 1.71e-03 | 18 |
GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
GO:005087810 | Cervix | CC | regulation of body fluid levels | 78/2311 | 379/18723 | 3.20e-06 | 8.77e-05 | 78 |
GO:003410910 | Cervix | CC | homotypic cell-cell adhesion | 26/2311 | 90/18723 | 2.12e-05 | 3.82e-04 | 26 |
GO:00705279 | Cervix | CC | platelet aggregation | 19/2311 | 67/18723 | 3.42e-04 | 3.58e-03 | 19 |
GO:00508176 | Cervix | CC | coagulation | 45/2311 | 222/18723 | 5.08e-04 | 4.94e-03 | 45 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0491518 | Breast | Precancer | Estrogen signaling pathway | 28/684 | 138/8465 | 4.10e-06 | 5.39e-05 | 4.13e-05 | 28 |
hsa05031 | Breast | Precancer | Amphetamine addiction | 14/684 | 69/8465 | 1.05e-03 | 7.35e-03 | 5.63e-03 | 14 |
hsa0516316 | Breast | Precancer | Human cytomegalovirus infection | 32/684 | 225/8465 | 1.13e-03 | 7.57e-03 | 5.80e-03 | 32 |
hsa0496110 | Breast | Precancer | Endocrine and other factor-regulated calcium reabsorption | 11/684 | 53/8465 | 2.92e-03 | 1.81e-02 | 1.39e-02 | 11 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0491519 | Breast | Precancer | Estrogen signaling pathway | 28/684 | 138/8465 | 4.10e-06 | 5.39e-05 | 4.13e-05 | 28 |
hsa050311 | Breast | Precancer | Amphetamine addiction | 14/684 | 69/8465 | 1.05e-03 | 7.35e-03 | 5.63e-03 | 14 |
hsa0516317 | Breast | Precancer | Human cytomegalovirus infection | 32/684 | 225/8465 | 1.13e-03 | 7.57e-03 | 5.80e-03 | 32 |
hsa0496111 | Breast | Precancer | Endocrine and other factor-regulated calcium reabsorption | 11/684 | 53/8465 | 2.92e-03 | 1.81e-02 | 1.39e-02 | 11 |
hsa0501224 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0471424 | Breast | IDC | Thermogenesis | 75/867 | 232/8465 | 8.41e-21 | 3.04e-19 | 2.27e-19 | 75 |
hsa0491523 | Breast | IDC | Estrogen signaling pathway | 35/867 | 138/8465 | 2.55e-07 | 5.18e-06 | 3.88e-06 | 35 |
hsa0511022 | Breast | IDC | Vibrio cholerae infection | 17/867 | 50/8465 | 4.82e-06 | 6.82e-05 | 5.10e-05 | 17 |
hsa050312 | Breast | IDC | Amphetamine addiction | 18/867 | 69/8465 | 1.42e-04 | 1.36e-03 | 1.01e-03 | 18 |
hsa0516324 | Breast | IDC | Human cytomegalovirus infection | 39/867 | 225/8465 | 6.66e-04 | 5.41e-03 | 4.05e-03 | 39 |
hsa0497122 | Breast | IDC | Gastric acid secretion | 16/867 | 76/8465 | 3.80e-03 | 2.33e-02 | 1.74e-02 | 16 |
hsa049704 | Breast | IDC | Salivary secretion | 18/867 | 93/8465 | 5.69e-03 | 3.13e-02 | 2.34e-02 | 18 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GNAS | SNV | Missense_Mutation | c.1738G>A | p.Glu580Lys | p.E580K | Q5JWF2 | protein_coding | deleterious_low_confidence(0.01) | benign(0.003) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD | |
GNAS | SNV | Missense_Mutation | c.2407C>T | p.Arg803Cys | p.R803C | Q5JWF2 | protein_coding | deleterious(0.01) | benign(0.335) | TCGA-HF-7132-01 | Stomach | stomach adenocarcinoma | Male | Unknown | I/II | Chemotherapy | fluorouracil | SD | |
GNAS | SNV | Missense_Mutation | rs11554273 | c.2530N>T | p.Arg844Cys | p.R844C | Q5JWF2 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
GNAS | SNV | Missense_Mutation | c.844N>A | p.Gly282Ser | p.G282S | Q5JWF2 | protein_coding | tolerated_low_confidence(0.38) | benign(0.003) | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD | |
GNAS | SNV | Missense_Mutation | novel | c.1631N>A | p.Arg544Gln | p.R544Q | Q5JWF2 | protein_coding | tolerated_low_confidence(0.52) | benign(0.003) | TCGA-HU-A4HB-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | ts-1 | PD |
GNAS | SNV | Missense_Mutation | novel | c.2722C>T | p.Arg908Cys | p.R908C | Q5JWF2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-VQ-A8PO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GNAS | SNV | Missense_Mutation | novel | c.920N>A | p.Pro307His | p.P307H | Q5JWF2 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.869) | TCGA-VQ-A922-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
GNAS | SNV | Missense_Mutation | c.1894N>T | p.Arg632Cys | p.R632C | Q5JWF2 | protein_coding | tolerated_low_confidence(0.08) | possibly_damaging(0.566) | TCGA-VQ-AA6D-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | CR | |
GNAS | SNV | Missense_Mutation | rs201342585 | c.958N>A | p.Asp320Asn | p.D320N | Q5JWF2 | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(0.919) | TCGA-VQ-AA6J-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
GNAS | SNV | Missense_Mutation | rs137854533 | c.2610N>T | p.Gln870His | p.Q870H | Q5JWF2 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BJ-A3F0-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | GARCINONE E | GARCINONE E | ||
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | BAS 01152706 | CHEMBL2002487 | ||
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | N-(3,4-DICHLOROPHENYL)BENZAMIDE | CHEMBL560296 | ||
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | TETRAETHYLAMMONIUM CHLORIDE | TETRAETHYLAMMONIUM CHLORIDE | ||
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | TCMDC-125620 | CHEMBL530291 | ||
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | CISPLATIN | CISPLATIN | 19274060 | |
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | TCMDC-124353 | CHEMBL529918 | ||
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | FLUOROURACIL | FLUOROURACIL | 19274060 | |
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | NICLOSAMIDE | NICLOSAMIDE | ||
2778 | GNAS | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, G PROTEIN COUPLED RECEPTOR, DRUG RESISTANCE, TRANSPORTER | 9,10-PHENANTHRENEQUINONE | 9,10-PHENANTHRENEQUINONE |
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