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Gene: FLRT2 |
Gene summary for FLRT2 |
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Gene information | Species | Human | Gene symbol | FLRT2 | Gene ID | 23768 |
Gene name | fibronectin leucine rich transmembrane protein 2 | |
Gene Alias | FLRT2 | |
Cytomap | 14q31.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O43155 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23768 | FLRT2 | P2T-E | Human | Esophagus | ESCC | 2.80e-04 | 5.03e-02 | 0.1177 |
23768 | FLRT2 | P5T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.53e-01 | 0.1327 |
23768 | FLRT2 | P10T-E | Human | Esophagus | ESCC | 1.85e-53 | 1.02e+00 | 0.116 |
23768 | FLRT2 | P11T-E | Human | Esophagus | ESCC | 6.84e-03 | 2.47e-01 | 0.1426 |
23768 | FLRT2 | P12T-E | Human | Esophagus | ESCC | 9.58e-20 | 4.57e-01 | 0.1122 |
23768 | FLRT2 | P15T-E | Human | Esophagus | ESCC | 5.23e-03 | 1.10e-01 | 0.1149 |
23768 | FLRT2 | P21T-E | Human | Esophagus | ESCC | 3.99e-05 | 1.35e-01 | 0.1617 |
23768 | FLRT2 | P24T-E | Human | Esophagus | ESCC | 1.41e-02 | 2.23e-01 | 0.1287 |
23768 | FLRT2 | P28T-E | Human | Esophagus | ESCC | 1.08e-16 | 4.83e-01 | 0.1149 |
23768 | FLRT2 | P31T-E | Human | Esophagus | ESCC | 6.47e-25 | 4.61e-01 | 0.1251 |
23768 | FLRT2 | P32T-E | Human | Esophagus | ESCC | 1.31e-17 | 3.98e-01 | 0.1666 |
23768 | FLRT2 | P37T-E | Human | Esophagus | ESCC | 6.65e-25 | 6.23e-01 | 0.1371 |
23768 | FLRT2 | P40T-E | Human | Esophagus | ESCC | 4.57e-02 | 9.13e-02 | 0.109 |
23768 | FLRT2 | P49T-E | Human | Esophagus | ESCC | 1.20e-13 | 1.31e+00 | 0.1768 |
23768 | FLRT2 | P52T-E | Human | Esophagus | ESCC | 5.22e-03 | 1.34e-01 | 0.1555 |
23768 | FLRT2 | P83T-E | Human | Esophagus | ESCC | 3.69e-14 | 6.62e-01 | 0.1738 |
23768 | FLRT2 | P91T-E | Human | Esophagus | ESCC | 8.92e-03 | 6.00e-01 | 0.1828 |
23768 | FLRT2 | P107T-E | Human | Esophagus | ESCC | 2.21e-12 | 4.93e-01 | 0.171 |
23768 | FLRT2 | C04 | Human | Oral cavity | OSCC | 8.49e-21 | 1.45e+00 | 0.2633 |
23768 | FLRT2 | C21 | Human | Oral cavity | OSCC | 4.08e-40 | 1.21e+00 | 0.2678 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00301984 | Esophagus | ESCC | extracellular matrix organization | 171/8552 | 301/18723 | 6.08e-05 | 4.67e-04 | 171 |
GO:00430624 | Esophagus | ESCC | extracellular structure organization | 171/8552 | 302/18723 | 7.73e-05 | 5.76e-04 | 171 |
GO:00452294 | Esophagus | ESCC | external encapsulating structure organization | 172/8552 | 304/18723 | 7.80e-05 | 5.80e-04 | 172 |
GO:006156415 | Esophagus | ESCC | axon development | 251/8552 | 467/18723 | 2.41e-04 | 1.49e-03 | 251 |
GO:003432918 | Esophagus | ESCC | cell junction assembly | 227/8552 | 420/18723 | 3.06e-04 | 1.83e-03 | 227 |
GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
GO:00519625 | Esophagus | ESCC | positive regulation of nervous system development | 149/8552 | 272/18723 | 1.50e-03 | 7.06e-03 | 149 |
GO:000740915 | Esophagus | ESCC | axonogenesis | 219/8552 | 418/18723 | 3.14e-03 | 1.31e-02 | 219 |
GO:00717115 | Esophagus | ESCC | basement membrane organization | 22/8552 | 31/18723 | 3.90e-03 | 1.58e-02 | 22 |
GO:190188810 | Esophagus | ESCC | regulation of cell junction assembly | 109/8552 | 204/18723 | 1.53e-02 | 4.96e-02 | 109 |
GO:00519624 | Oral cavity | OSCC | positive regulation of nervous system development | 135/7305 | 272/18723 | 2.20e-04 | 1.44e-03 | 135 |
GO:00301983 | Oral cavity | OSCC | extracellular matrix organization | 146/7305 | 301/18723 | 4.67e-04 | 2.77e-03 | 146 |
GO:00452293 | Oral cavity | OSCC | external encapsulating structure organization | 147/7305 | 304/18723 | 5.30e-04 | 3.08e-03 | 147 |
GO:00430623 | Oral cavity | OSCC | extracellular structure organization | 146/7305 | 302/18723 | 5.59e-04 | 3.23e-03 | 146 |
GO:00519605 | Oral cavity | OSCC | regulation of nervous system development | 205/7305 | 443/18723 | 9.80e-04 | 5.11e-03 | 205 |
GO:00717114 | Oral cavity | OSCC | basement membrane organization | 20/7305 | 31/18723 | 3.57e-03 | 1.49e-02 | 20 |
GO:003432916 | Oral cavity | OSCC | cell junction assembly | 190/7305 | 420/18723 | 4.99e-03 | 1.96e-02 | 190 |
GO:006156410 | Oral cavity | OSCC | axon development | 207/7305 | 467/18723 | 1.01e-02 | 3.51e-02 | 207 |
GO:003432923 | Oral cavity | NEOLP | cell junction assembly | 88/2005 | 420/18723 | 4.18e-10 | 3.44e-08 | 88 |
GO:00301982 | Oral cavity | NEOLP | extracellular matrix organization | 64/2005 | 301/18723 | 5.66e-08 | 2.24e-06 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FLRT2 | SNV | Missense_Mutation | rs201981148 | c.1649N>T | p.Ala550Val | p.A550V | O43155 | protein_coding | tolerated(0.08) | possibly_damaging(0.638) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
FLRT2 | SNV | Missense_Mutation | c.1684T>G | p.Phe562Val | p.F562V | O43155 | protein_coding | tolerated(0.39) | possibly_damaging(0.589) | TCGA-CG-4469-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | SD | |
FLRT2 | SNV | Missense_Mutation | c.1238N>A | p.Gly413Asp | p.G413D | O43155 | protein_coding | tolerated(0.42) | benign(0) | TCGA-D7-5578-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
FLRT2 | SNV | Missense_Mutation | rs201981148 | c.1649C>T | p.Ala550Val | p.A550V | O43155 | protein_coding | tolerated(0.08) | possibly_damaging(0.638) | TCGA-FP-7916-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
FLRT2 | SNV | Missense_Mutation | rs766170020 | c.122G>A | p.Arg41His | p.R41H | O43155 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-FP-A9TM-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
FLRT2 | SNV | Missense_Mutation | novel | c.1679N>T | p.Ser560Ile | p.S560I | O43155 | protein_coding | deleterious(0.02) | benign(0.165) | TCGA-HF-A5NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD |
FLRT2 | SNV | Missense_Mutation | rs181491350 | c.839N>A | p.Arg280Gln | p.R280Q | O43155 | protein_coding | deleterious(0) | benign(0.375) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
FLRT2 | SNV | Missense_Mutation | c.506N>C | p.Asn169Thr | p.N169T | O43155 | protein_coding | deleterious(0) | possibly_damaging(0.54) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FLRT2 | SNV | Missense_Mutation | rs765614375 | c.623N>A | p.Arg208His | p.R208H | O43155 | protein_coding | deleterious(0.01) | benign(0.093) | TCGA-HU-A4GX-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | SD |
FLRT2 | SNV | Missense_Mutation | c.1750N>T | p.Arg584Trp | p.R584W | O43155 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-HU-A4H3-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | ts-1 | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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