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Gene: FILIP1 |
Gene summary for FILIP1 |
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Gene information | Species | Human | Gene symbol | FILIP1 | Gene ID | 27145 |
Gene name | filamin A interacting protein 1 | |
Gene Alias | FILIP | |
Cytomap | 6q14.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q7Z7B0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27145 | FILIP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.98e-05 | 2.45e-01 | -0.1088 |
27145 | FILIP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.34e-06 | 2.28e-01 | -0.1954 |
27145 | FILIP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.15e-04 | 2.86e-01 | -0.059 |
27145 | FILIP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.19e-03 | 2.63e-01 | 0.096 |
27145 | FILIP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.16e-03 | 4.30e-01 | 0.0131 |
27145 | FILIP1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.10e-02 | 3.80e-01 | 0.0112 |
27145 | FILIP1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.42e-12 | 4.25e-01 | 0.3859 |
27145 | FILIP1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.47e-11 | 5.39e-01 | 0.2585 |
27145 | FILIP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.62e-04 | 2.32e-01 | 0.3005 |
27145 | FILIP1 | HCC2 | Human | Liver | HCC | 1.51e-07 | 1.39e+00 | 0.5341 |
27145 | FILIP1 | Pt13.b | Human | Liver | HCC | 2.81e-14 | 3.56e-01 | 0.0251 |
27145 | FILIP1 | S014 | Human | Liver | HCC | 5.55e-25 | 1.19e+00 | 0.2254 |
27145 | FILIP1 | S015 | Human | Liver | HCC | 4.93e-30 | 1.41e+00 | 0.2375 |
27145 | FILIP1 | S016 | Human | Liver | HCC | 1.06e-40 | 1.33e+00 | 0.2243 |
27145 | FILIP1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 3.59e-07 | 4.71e-01 | -0.2116 |
27145 | FILIP1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.14e-09 | 5.45e-01 | -0.2119 |
27145 | FILIP1 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 1.26e-02 | 7.47e-01 | -0.0296 |
27145 | FILIP1 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 2.59e-04 | 6.99e-01 | -0.0263 |
27145 | FILIP1 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 1.46e-02 | 6.04e-01 | -0.0961 |
27145 | FILIP1 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 3.07e-06 | 7.88e-01 | -0.0876 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FILIP1 | SNV | Missense_Mutation | novel | c.2308C>T | p.Leu770Phe | p.L770F | Q7Z7B0 | protein_coding | tolerated(0.22) | benign(0.003) | TCGA-KK-A8IA-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Hormone Therapy | lupron | SD |
FILIP1 | SNV | Missense_Mutation | novel | c.2936C>T | p.Ser979Phe | p.S979F | Q7Z7B0 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-VN-A88O-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
FILIP1 | SNV | Missense_Mutation | rs554789463 | c.2744N>T | p.Thr915Ile | p.T915I | Q7Z7B0 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-B7-5816-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FILIP1 | SNV | Missense_Mutation | c.1886T>C | p.Ile629Thr | p.I629T | Q7Z7B0 | protein_coding | deleterious(0.01) | benign(0.334) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FILIP1 | SNV | Missense_Mutation | c.563N>T | p.His188Leu | p.H188L | Q7Z7B0 | protein_coding | deleterious(0.01) | benign(0.173) | TCGA-BR-7197-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FILIP1 | SNV | Missense_Mutation | c.814N>G | p.Thr272Ala | p.T272A | Q7Z7B0 | protein_coding | tolerated(0.1) | benign(0.009) | TCGA-BR-7703-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FILIP1 | SNV | Missense_Mutation | c.3638G>A | p.Gly1213Asp | p.G1213D | Q7Z7B0 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.601) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
FILIP1 | SNV | Missense_Mutation | c.130A>G | p.Arg44Gly | p.R44G | Q7Z7B0 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR | |
FILIP1 | SNV | Missense_Mutation | rs112240066 | c.73G>A | p.Gly25Ser | p.G25S | Q7Z7B0 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FILIP1 | SNV | Missense_Mutation | c.320N>C | p.Lys107Thr | p.K107T | Q7Z7B0 | protein_coding | tolerated(0.26) | benign(0.173) | TCGA-D7-6526-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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