![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DNAH5 |
Gene summary for DNAH5 |
![]() |
Gene information | Species | Human | Gene symbol | DNAH5 | Gene ID | 1767 |
Gene name | dynein axonemal heavy chain 5 | |
Gene Alias | CILD3 | |
Cytomap | 5p15.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8TE73 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1767 | DNAH5 | C04 | Human | Oral cavity | OSCC | 2.09e-35 | 1.82e+00 | 0.2633 |
1767 | DNAH5 | C21 | Human | Oral cavity | OSCC | 7.14e-04 | 1.57e-01 | 0.2678 |
1767 | DNAH5 | SYSMH2 | Human | Oral cavity | OSCC | 4.32e-07 | 6.58e-01 | 0.2326 |
1767 | DNAH5 | SYSMH3 | Human | Oral cavity | OSCC | 5.39e-16 | 7.09e-01 | 0.2442 |
1767 | DNAH5 | SYSMH5 | Human | Oral cavity | OSCC | 1.09e-26 | 1.05e+00 | 0.0647 |
1767 | DNAH5 | HTA12-25-1 | Human | Pancreas | PDAC | 2.50e-03 | 4.72e-01 | 0.313 |
1767 | DNAH5 | HTA12-26-1 | Human | Pancreas | PDAC | 4.34e-14 | 7.27e-01 | 0.3728 |
1767 | DNAH5 | HTA12-29-1 | Human | Pancreas | PDAC | 6.09e-12 | 3.98e-01 | 0.3722 |
1767 | DNAH5 | HTA12-32-1 | Human | Pancreas | PDAC | 1.20e-02 | 7.98e-01 | 0.3624 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00991113 | Oral cavity | OSCC | microtubule-based transport | 96/7305 | 190/18723 | 7.92e-04 | 4.27e-03 | 96 |
GO:0021591 | Oral cavity | OSCC | ventricular system development | 18/7305 | 29/18723 | 1.00e-02 | 3.49e-02 | 18 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501428 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa0501628 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
hsa0502228 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
hsa05014112 | Oral cavity | OSCC | Amyotrophic lateral sclerosis | 246/3704 | 364/8465 | 6.65e-21 | 1.11e-18 | 5.67e-19 | 246 |
hsa05016112 | Oral cavity | OSCC | Huntington disease | 204/3704 | 306/8465 | 1.70e-16 | 7.13e-15 | 3.63e-15 | 204 |
hsa05022112 | Oral cavity | OSCC | Pathways of neurodegeneration - multiple diseases | 292/3704 | 476/8465 | 1.60e-15 | 4.47e-14 | 2.28e-14 | 292 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAH5 | SNV | Missense_Mutation | novel | c.13739N>A | p.Arg4580Gln | p.R4580Q | Q8TE73 | protein_coding | tolerated(0.07) | benign(0.009) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DNAH5 | SNV | Missense_Mutation | rs200704983 | c.2945N>A | p.Arg982His | p.R982H | Q8TE73 | protein_coding | deleterious(0.01) | benign(0.068) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DNAH5 | SNV | Missense_Mutation | rs757897932 | c.9856G>A | p.Ala3286Thr | p.A3286T | Q8TE73 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DNAH5 | SNV | Missense_Mutation | novel | c.8389C>T | p.Leu2797Phe | p.L2797F | Q8TE73 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DNAH5 | SNV | Missense_Mutation | c.8165G>T | p.Arg2722Met | p.R2722M | Q8TE73 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DNAH5 | SNV | Missense_Mutation | rs143894811 | c.5929G>T | p.Ala1977Ser | p.A1977S | Q8TE73 | protein_coding | tolerated(0.14) | possibly_damaging(0.785) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DNAH5 | SNV | Missense_Mutation | novel | c.5737G>T | p.Asp1913Tyr | p.D1913Y | Q8TE73 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DNAH5 | SNV | Missense_Mutation | novel | c.3911A>G | p.Tyr1304Cys | p.Y1304C | Q8TE73 | protein_coding | deleterious(0.02) | probably_damaging(0.96) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DNAH5 | SNV | Missense_Mutation | novel | c.3679A>G | p.Ser1227Gly | p.S1227G | Q8TE73 | protein_coding | tolerated(0.14) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DNAH5 | SNV | Missense_Mutation | novel | c.3516G>T | p.Gln1172His | p.Q1172H | Q8TE73 | protein_coding | deleterious(0.04) | benign(0.003) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |