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Gene: DIP2B |
Gene summary for DIP2B |
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Gene information | Species | Human | Gene symbol | DIP2B | Gene ID | 57609 |
Gene name | disco interacting protein 2 homolog B | |
Gene Alias | DIP2B | |
Cytomap | 12q13.12 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q7Z3H2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57609 | DIP2B | CCI_1 | Human | Cervix | CC | 9.65e-16 | 1.76e+00 | 0.528 |
57609 | DIP2B | CCI_2 | Human | Cervix | CC | 6.99e-17 | 1.54e+00 | 0.5249 |
57609 | DIP2B | CCI_3 | Human | Cervix | CC | 2.44e-19 | 1.75e+00 | 0.516 |
57609 | DIP2B | sample3 | Human | Cervix | CC | 3.24e-02 | 1.72e-01 | 0.1387 |
57609 | DIP2B | T3 | Human | Cervix | CC | 9.64e-04 | 1.60e-01 | 0.1389 |
57609 | DIP2B | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.02e-12 | -4.95e-01 | 0.0155 |
57609 | DIP2B | HTA11_347_2000001011 | Human | Colorectum | AD | 6.93e-08 | 5.22e-01 | -0.1954 |
57609 | DIP2B | HTA11_866_3004761011 | Human | Colorectum | AD | 1.99e-07 | -4.42e-01 | 0.096 |
57609 | DIP2B | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.60e-02 | -5.39e-01 | 0.2585 |
57609 | DIP2B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.51e-15 | -5.76e-01 | 0.3005 |
57609 | DIP2B | F007 | Human | Colorectum | FAP | 6.95e-04 | -2.62e-01 | 0.1176 |
57609 | DIP2B | A001-C-207 | Human | Colorectum | FAP | 1.09e-03 | -2.35e-01 | 0.1278 |
57609 | DIP2B | A015-C-203 | Human | Colorectum | FAP | 3.74e-42 | -7.16e-01 | -0.1294 |
57609 | DIP2B | A015-C-204 | Human | Colorectum | FAP | 1.18e-11 | -4.69e-01 | -0.0228 |
57609 | DIP2B | A014-C-040 | Human | Colorectum | FAP | 5.40e-09 | -6.08e-01 | -0.1184 |
57609 | DIP2B | A002-C-201 | Human | Colorectum | FAP | 1.19e-26 | -6.66e-01 | 0.0324 |
57609 | DIP2B | A002-C-203 | Human | Colorectum | FAP | 5.96e-07 | -2.82e-01 | 0.2786 |
57609 | DIP2B | A001-C-119 | Human | Colorectum | FAP | 6.03e-08 | -2.81e-01 | -0.1557 |
57609 | DIP2B | A001-C-108 | Human | Colorectum | FAP | 4.03e-22 | -3.68e-01 | -0.0272 |
57609 | DIP2B | A002-C-205 | Human | Colorectum | FAP | 3.70e-34 | -6.06e-01 | -0.1236 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00109757 | Cervix | CC | regulation of neuron projection development | 88/2311 | 445/18723 | 4.26e-06 | 1.09e-04 | 88 |
GO:00160498 | Cervix | CC | cell growth | 92/2311 | 482/18723 | 1.16e-05 | 2.49e-04 | 92 |
GO:00325359 | Cervix | CC | regulation of cellular component size | 76/2311 | 383/18723 | 1.66e-05 | 3.21e-04 | 76 |
GO:00615647 | Cervix | CC | axon development | 89/2311 | 467/18723 | 1.71e-05 | 3.27e-04 | 89 |
GO:00074097 | Cervix | CC | axonogenesis | 78/2311 | 418/18723 | 1.14e-04 | 1.43e-03 | 78 |
GO:00015588 | Cervix | CC | regulation of cell growth | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
GO:00507705 | Cervix | CC | regulation of axonogenesis | 34/2311 | 154/18723 | 4.87e-04 | 4.76e-03 | 34 |
GO:00313456 | Cervix | CC | negative regulation of cell projection organization | 39/2311 | 186/18723 | 5.86e-04 | 5.57e-03 | 39 |
GO:00486386 | Cervix | CC | regulation of developmental growth | 61/2311 | 330/18723 | 7.69e-04 | 6.85e-03 | 61 |
GO:00605606 | Cervix | CC | developmental growth involved in morphogenesis | 46/2311 | 234/18723 | 8.82e-04 | 7.63e-03 | 46 |
GO:00519603 | Cervix | CC | regulation of nervous system development | 77/2311 | 443/18723 | 1.13e-03 | 9.30e-03 | 77 |
GO:00507676 | Cervix | CC | regulation of neurogenesis | 65/2311 | 364/18723 | 1.33e-03 | 1.05e-02 | 65 |
GO:00486756 | Cervix | CC | axon extension | 26/2311 | 120/18723 | 2.80e-03 | 1.87e-02 | 26 |
GO:19901385 | Cervix | CC | neuron projection extension | 34/2311 | 172/18723 | 3.52e-03 | 2.27e-02 | 34 |
GO:00109775 | Cervix | CC | negative regulation of neuron projection development | 28/2311 | 137/18723 | 4.74e-03 | 2.83e-02 | 28 |
GO:00485886 | Cervix | CC | developmental cell growth | 42/2311 | 234/18723 | 7.88e-03 | 4.15e-02 | 42 |
GO:00182054 | Cervix | CC | peptidyl-lysine modification | 62/2311 | 376/18723 | 1.04e-02 | 4.97e-02 | 62 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
GO:0001558 | Colorectum | AD | regulation of cell growth | 124/3918 | 414/18723 | 7.67e-06 | 1.86e-04 | 124 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DIP2B | SNV | Missense_Mutation | novel | c.2671G>C | p.Val891Leu | p.V891L | Q9P265 | protein_coding | deleterious(0.05) | benign(0.309) | TCGA-T3-A92M-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
DIP2B | SNV | Missense_Mutation | rs138370328 | c.4528G>A | p.Gly1510Ser | p.G1510S | Q9P265 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
DIP2B | SNV | Missense_Mutation | c.1708N>A | p.Gly570Ser | p.G570S | Q9P265 | protein_coding | tolerated(0.47) | benign(0.253) | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
DIP2B | SNV | Missense_Mutation | c.1715N>C | p.Phe572Ser | p.F572S | Q9P265 | protein_coding | deleterious(0) | benign(0.065) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DIP2B | SNV | Missense_Mutation | c.4637N>T | p.Pro1546Leu | p.P1546L | Q9P265 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DIP2B | SNV | Missense_Mutation | rs777760335 | c.3532N>A | p.Ala1178Thr | p.A1178T | Q9P265 | protein_coding | tolerated(0.12) | benign(0.26) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DIP2B | SNV | Missense_Mutation | c.839T>G | p.Leu280Arg | p.L280R | Q9P265 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
DIP2B | SNV | Missense_Mutation | c.4249C>A | p.His1417Asn | p.H1417N | Q9P265 | protein_coding | tolerated(0.08) | probably_damaging(0.974) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
DIP2B | SNV | Missense_Mutation | c.2498N>C | p.Leu833Ser | p.L833S | Q9P265 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DIP2B | SNV | Missense_Mutation | c.253T>C | p.Tyr85His | p.Y85H | Q9P265 | protein_coding | tolerated(0.54) | benign(0.003) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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