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Gene: CRYBG3 |
Gene summary for CRYBG3 |
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Gene information | Species | Human | Gene symbol | CRYBG3 | Gene ID | 131544 |
Gene name | crystallin beta-gamma domain containing 3 | |
Gene Alias | DKFZp667G2110 | |
Cytomap | 3q11.2 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | Q68DQ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
131544 | CRYBG3 | LZE2T | Human | Esophagus | ESCC | 3.17e-04 | 5.04e-01 | 0.082 |
131544 | CRYBG3 | LZE4T | Human | Esophagus | ESCC | 2.32e-03 | 6.26e-02 | 0.0811 |
131544 | CRYBG3 | LZE5T | Human | Esophagus | ESCC | 1.34e-04 | 4.07e-01 | 0.0514 |
131544 | CRYBG3 | LZE8T | Human | Esophagus | ESCC | 3.04e-09 | 4.49e-01 | 0.067 |
131544 | CRYBG3 | LZE20T | Human | Esophagus | ESCC | 6.34e-03 | 1.61e-01 | 0.0662 |
131544 | CRYBG3 | LZE24T | Human | Esophagus | ESCC | 1.66e-14 | 2.78e-01 | 0.0596 |
131544 | CRYBG3 | P1T-E | Human | Esophagus | ESCC | 4.95e-13 | 3.73e-01 | 0.0875 |
131544 | CRYBG3 | P2T-E | Human | Esophagus | ESCC | 1.16e-08 | 1.36e-01 | 0.1177 |
131544 | CRYBG3 | P4T-E | Human | Esophagus | ESCC | 3.47e-11 | 2.64e-01 | 0.1323 |
131544 | CRYBG3 | P5T-E | Human | Esophagus | ESCC | 5.99e-10 | 1.85e-01 | 0.1327 |
131544 | CRYBG3 | P8T-E | Human | Esophagus | ESCC | 7.43e-28 | 5.12e-01 | 0.0889 |
131544 | CRYBG3 | P9T-E | Human | Esophagus | ESCC | 3.08e-15 | 4.84e-01 | 0.1131 |
131544 | CRYBG3 | P10T-E | Human | Esophagus | ESCC | 1.11e-20 | 2.73e-01 | 0.116 |
131544 | CRYBG3 | P11T-E | Human | Esophagus | ESCC | 1.47e-03 | 1.93e-01 | 0.1426 |
131544 | CRYBG3 | P12T-E | Human | Esophagus | ESCC | 2.50e-06 | 1.71e-01 | 0.1122 |
131544 | CRYBG3 | P17T-E | Human | Esophagus | ESCC | 8.68e-03 | 1.32e-01 | 0.1278 |
131544 | CRYBG3 | P20T-E | Human | Esophagus | ESCC | 6.49e-17 | 3.59e-01 | 0.1124 |
131544 | CRYBG3 | P21T-E | Human | Esophagus | ESCC | 1.80e-19 | 4.62e-01 | 0.1617 |
131544 | CRYBG3 | P22T-E | Human | Esophagus | ESCC | 3.07e-13 | 2.37e-01 | 0.1236 |
131544 | CRYBG3 | P23T-E | Human | Esophagus | ESCC | 3.90e-17 | 5.67e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CRYBG3 | SNV | Missense_Mutation | novel | c.2688N>T | p.Glu896Asp | p.E896D | Q68DQ2 | protein_coding | tolerated_low_confidence(0.07) | benign(0.028) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
CRYBG3 | SNV | Missense_Mutation | novel | c.5909N>C | p.Ile1970Thr | p.I1970T | Q68DQ2 | protein_coding | deleterious(0) | benign(0.216) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
CRYBG3 | SNV | Missense_Mutation | novel | c.6648N>T | p.Lys2216Asn | p.K2216N | Q68DQ2 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
CRYBG3 | SNV | Missense_Mutation | novel | c.2426N>T | p.Thr809Ile | p.T809I | Q68DQ2 | protein_coding | tolerated(0.18) | benign(0.028) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CRYBG3 | SNV | Missense_Mutation | novel | c.3254N>A | p.Ser1085Tyr | p.S1085Y | Q68DQ2 | protein_coding | deleterious(0.03) | benign(0.315) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CRYBG3 | SNV | Missense_Mutation | novel | c.3624N>G | p.Phe1208Leu | p.F1208L | Q68DQ2 | protein_coding | tolerated(0.23) | benign(0.071) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CRYBG3 | SNV | Missense_Mutation | novel | c.7514N>C | p.Asn2505Thr | p.N2505T | Q68DQ2 | protein_coding | tolerated(0.13) | benign(0.09) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CRYBG3 | SNV | Missense_Mutation | novel | c.3059N>A | p.Ser1020Tyr | p.S1020Y | Q68DQ2 | protein_coding | tolerated(0.1) | benign(0.038) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CRYBG3 | SNV | Missense_Mutation | novel | c.5593N>A | p.Ala1865Thr | p.A1865T | Q68DQ2 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CRYBG3 | SNV | Missense_Mutation | novel | c.6403N>C | p.Lys2135Gln | p.K2135Q | Q68DQ2 | protein_coding | tolerated(0.33) | possibly_damaging(0.678) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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