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Gene: CNTN1 |
Gene summary for CNTN1 |
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Gene information | Species | Human | Gene symbol | CNTN1 | Gene ID | 1272 |
Gene name | contactin 1 | |
Gene Alias | F3 | |
Cytomap | 12q12 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q12860 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1272 | CNTN1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.78e-12 | 7.55e-01 | -0.2116 |
1272 | CNTN1 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 5.12e-03 | 6.63e-01 | -0.1941 |
1272 | CNTN1 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 5.63e-05 | 6.19e-01 | -0.2107 |
1272 | CNTN1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 8.69e-11 | 7.87e-01 | -0.2119 |
1272 | CNTN1 | HTA12-15-2 | Human | Pancreas | PDAC | 4.41e-04 | 3.40e-01 | 0.2315 |
1272 | CNTN1 | HTA12-23-1 | Human | Pancreas | PDAC | 8.00e-12 | 8.99e-01 | 0.3405 |
1272 | CNTN1 | HTA12-25-1 | Human | Pancreas | PDAC | 2.04e-11 | 7.12e-01 | 0.313 |
1272 | CNTN1 | HTA12-26-1 | Human | Pancreas | PDAC | 5.25e-22 | 9.08e-01 | 0.3728 |
1272 | CNTN1 | HTA12-29-1 | Human | Pancreas | PDAC | 1.15e-54 | 1.13e+00 | 0.3722 |
1272 | CNTN1 | HTA12-30-1 | Human | Pancreas | PDAC | 1.14e-02 | 8.18e-01 | 0.3671 |
1272 | CNTN1 | HTA12-9-2 | Human | Pancreas | PDAC | 1.65e-02 | 2.54e-01 | 0.0835 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001097512 | Lung | AIS | regulation of neuron projection development | 69/1849 | 445/18723 | 1.05e-04 | 2.53e-03 | 69 |
GO:003134612 | Lung | AIS | positive regulation of cell projection organization | 57/1849 | 353/18723 | 1.38e-04 | 3.05e-03 | 57 |
GO:000202811 | Lung | AIS | regulation of sodium ion transport | 21/1849 | 90/18723 | 1.44e-04 | 3.13e-03 | 21 |
GO:0018212 | Lung | AIS | peptidyl-tyrosine modification | 56/1849 | 378/18723 | 1.35e-03 | 1.68e-02 | 56 |
GO:0018108 | Lung | AIS | peptidyl-tyrosine phosphorylation | 55/1849 | 375/18723 | 1.87e-03 | 2.08e-02 | 55 |
GO:001095912 | Lung | AIS | regulation of metal ion transport | 58/1849 | 406/18723 | 2.63e-03 | 2.67e-02 | 58 |
GO:00072193 | Lung | AIS | Notch signaling pathway | 29/1849 | 172/18723 | 2.93e-03 | 2.92e-02 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
CNTN1 | NRCAM | CNTN1_NRCAM | CNTN | HNSCC | Precancer |
CNTN1 | NRCAM | CNTN1_NRCAM | CNTN | Skin | AK |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CNTN1 | SNV | Missense_Mutation | c.851G>T | p.Ser284Ile | p.S284I | Q12860 | protein_coding | tolerated(0.08) | possibly_damaging(0.693) | TCGA-77-7141-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CNTN1 | SNV | Missense_Mutation | c.697N>A | p.Pro233Thr | p.P233T | Q12860 | protein_coding | tolerated(0.73) | benign(0.003) | TCGA-85-6561-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD | |
CNTN1 | SNV | Missense_Mutation | novel | c.2372N>C | p.Gly791Ala | p.G791A | Q12860 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-85-8287-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CNTN1 | SNV | Missense_Mutation | rs773622747 | c.2932N>A | p.Ala978Thr | p.A978T | Q12860 | protein_coding | tolerated(0.27) | benign(0.088) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CNTN1 | SNV | Missense_Mutation | novel | c.650N>A | p.Ser217Tyr | p.S217Y | Q12860 | protein_coding | tolerated(1) | probably_damaging(0.954) | TCGA-NC-A5HM-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CNTN1 | SNV | Missense_Mutation | novel | c.733N>A | p.Val245Ile | p.V245I | Q12860 | protein_coding | deleterious(0.04) | benign(0.131) | TCGA-O2-A52N-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CNTN1 | SNV | Missense_Mutation | novel | c.983N>T | p.Gln328Leu | p.Q328L | Q12860 | protein_coding | deleterious(0.01) | possibly_damaging(0.496) | TCGA-O2-A5IB-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
CNTN1 | insertion | Frame_Shift_Ins | novel | c.477_478insA | p.Pro160ThrfsTer8 | p.P160Tfs*8 | Q12860 | protein_coding | TCGA-55-8094-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
CNTN1 | SNV | Missense_Mutation | novel | c.1739N>A | p.Arg580Lys | p.R580K | Q12860 | protein_coding | tolerated(0.79) | benign(0.241) | TCGA-CN-6013-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
CNTN1 | SNV | Missense_Mutation | novel | c.31G>T | p.Val11Leu | p.V11L | Q12860 | protein_coding | tolerated(1) | benign(0) | TCGA-CN-6024-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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