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Gene: AKAP11 |
Gene summary for AKAP11 |
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Gene information | Species | Human | Gene symbol | AKAP11 | Gene ID | 11215 |
Gene name | A-kinase anchoring protein 11 | |
Gene Alias | AKAP-11 | |
Cytomap | 13q14.11 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9UKA4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11215 | AKAP11 | HCC1_Meng | Human | Liver | HCC | 4.53e-51 | 2.93e-02 | 0.0246 |
11215 | AKAP11 | HCC2_Meng | Human | Liver | HCC | 7.46e-25 | 2.05e-01 | 0.0107 |
11215 | AKAP11 | HCC1 | Human | Liver | HCC | 2.18e-06 | 4.20e+00 | 0.5336 |
11215 | AKAP11 | HCC2 | Human | Liver | HCC | 1.74e-09 | 4.09e+00 | 0.5341 |
11215 | AKAP11 | S028 | Human | Liver | HCC | 1.81e-09 | 4.87e-01 | 0.2503 |
11215 | AKAP11 | S029 | Human | Liver | HCC | 9.88e-03 | 3.58e-01 | 0.2581 |
11215 | AKAP11 | Dong_P1 | Human | Prostate | Tumor | 1.12e-08 | 6.22e-02 | 0.035 |
11215 | AKAP11 | Dong_P3 | Human | Prostate | Tumor | 2.20e-11 | 1.44e-01 | 0.0278 |
11215 | AKAP11 | GSM5353215_PA_AUG_PB_1B_S2 | Human | Prostate | Tumor | 4.82e-02 | 5.35e-01 | 0.1557 |
11215 | AKAP11 | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 1.53e-04 | 6.82e-01 | 0.159 |
11215 | AKAP11 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 8.91e-11 | 5.24e-01 | 0.1633 |
11215 | AKAP11 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 4.61e-08 | 4.25e-01 | 0.1608 |
11215 | AKAP11 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 7.65e-07 | 4.23e-01 | 0.1604 |
11215 | AKAP11 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 4.64e-02 | 2.23e-01 | 0.1621 |
11215 | AKAP11 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 3.13e-03 | 3.56e-01 | 0.1602 |
11215 | AKAP11 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 2.18e-02 | 3.09e-01 | 0.1569 |
11215 | AKAP11 | male-WTA | Human | Thyroid | PTC | 6.70e-32 | 2.42e-01 | 0.1037 |
11215 | AKAP11 | PTC01 | Human | Thyroid | PTC | 1.64e-09 | 1.09e-01 | 0.1899 |
11215 | AKAP11 | PTC03 | Human | Thyroid | PTC | 5.71e-04 | 1.73e-01 | 0.1784 |
11215 | AKAP11 | PTC04 | Human | Thyroid | PTC | 2.05e-09 | 2.17e-01 | 0.1927 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003086512 | Liver | HCC | cortical cytoskeleton organization | 47/7958 | 61/18723 | 4.03e-08 | 8.69e-07 | 47 |
GO:003086612 | Liver | HCC | cortical actin cytoskeleton organization | 30/7958 | 40/18723 | 3.04e-05 | 3.12e-04 | 30 |
GO:00360103 | Liver | HCC | protein localization to endosome | 19/7958 | 24/18723 | 2.80e-04 | 2.02e-03 | 19 |
GO:005087822 | Liver | HCC | regulation of body fluid levels | 191/7958 | 379/18723 | 1.06e-03 | 6.11e-03 | 191 |
GO:003086515 | Prostate | Tumor | cortical cytoskeleton organization | 24/3246 | 61/18723 | 3.91e-05 | 4.52e-04 | 24 |
GO:005087818 | Prostate | Tumor | regulation of body fluid levels | 91/3246 | 379/18723 | 5.37e-04 | 3.91e-03 | 91 |
GO:003086613 | Prostate | Tumor | cortical actin cytoskeleton organization | 15/3246 | 40/18723 | 1.91e-03 | 1.11e-02 | 15 |
GO:003601011 | Prostate | Tumor | protein localization to endosome | 10/3246 | 24/18723 | 4.46e-03 | 2.20e-02 | 10 |
GO:0030865110 | Thyroid | PTC | cortical cytoskeleton organization | 38/5968 | 61/18723 | 9.77e-07 | 1.46e-05 | 38 |
GO:003086616 | Thyroid | PTC | cortical actin cytoskeleton organization | 25/5968 | 40/18723 | 6.51e-05 | 5.72e-04 | 25 |
GO:003086523 | Thyroid | ATC | cortical cytoskeleton organization | 41/6293 | 61/18723 | 8.28e-08 | 1.43e-06 | 41 |
GO:003086617 | Thyroid | ATC | cortical actin cytoskeleton organization | 28/6293 | 40/18723 | 2.77e-06 | 3.19e-05 | 28 |
GO:0050878112 | Thyroid | ATC | regulation of body fluid levels | 149/6293 | 379/18723 | 1.08e-02 | 3.90e-02 | 149 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AKAP11 | SNV | Missense_Mutation | novel | c.5451N>A | p.Met1817Ile | p.M1817I | Q9UKA4 | protein_coding | tolerated(0.19) | benign(0.052) | TCGA-64-1678-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
AKAP11 | SNV | Missense_Mutation | novel | c.299G>C | p.Cys100Ser | p.C100S | Q9UKA4 | protein_coding | deleterious(0.02) | possibly_damaging(0.827) | TCGA-69-7974-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
AKAP11 | SNV | Missense_Mutation | c.4744C>G | p.Leu1582Val | p.L1582V | Q9UKA4 | protein_coding | tolerated(0.13) | possibly_damaging(0.84) | TCGA-78-7154-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
AKAP11 | SNV | Missense_Mutation | novel | c.3912N>T | p.Leu1304Phe | p.L1304F | Q9UKA4 | protein_coding | tolerated(0.43) | benign(0.329) | TCGA-86-7701-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | etoposide | PD |
AKAP11 | SNV | Missense_Mutation | novel | c.5008N>T | p.Ser1670Cys | p.S1670C | Q9UKA4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-86-8279-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR |
AKAP11 | SNV | Missense_Mutation | novel | c.1525A>T | p.Thr509Ser | p.T509S | Q9UKA4 | protein_coding | tolerated(0.75) | benign(0.005) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
AKAP11 | SNV | Missense_Mutation | c.410G>T | p.Arg137Met | p.R137M | Q9UKA4 | protein_coding | deleterious(0.01) | probably_damaging(0.912) | TCGA-97-A4M7-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AKAP11 | SNV | Missense_Mutation | c.5360N>G | p.Asp1787Gly | p.D1787G | Q9UKA4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-MP-A4SY-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
AKAP11 | SNV | Missense_Mutation | novel | c.1192C>G | p.Pro398Ala | p.P398A | Q9UKA4 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-21-1081-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
AKAP11 | SNV | Missense_Mutation | novel | c.2726A>G | p.Lys909Arg | p.K909R | Q9UKA4 | protein_coding | tolerated(0.44) | benign(0.015) | TCGA-22-1000-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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