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Gene: ZNF568 |
Gene summary for ZNF568 |
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Gene information | Species | Human | Gene symbol | ZNF568 | Gene ID | 374900 |
Gene name | zinc finger protein 568 | |
Gene Alias | ZFP568 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A2VDJ6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
374900 | ZNF568 | HCC2 | Human | Liver | HCC | 1.10e-05 | 1.43e+00 | 0.5341 |
374900 | ZNF568 | Pt13.b | Human | Liver | HCC | 4.21e-03 | 3.92e-02 | 0.0251 |
374900 | ZNF568 | S014 | Human | Liver | HCC | 5.93e-22 | 7.23e-01 | 0.2254 |
374900 | ZNF568 | S015 | Human | Liver | HCC | 1.74e-12 | 7.71e-01 | 0.2375 |
374900 | ZNF568 | S016 | Human | Liver | HCC | 3.92e-26 | 7.19e-01 | 0.2243 |
374900 | ZNF568 | PTC05 | Human | Thyroid | PTC | 5.22e-03 | 1.75e-01 | 0.2065 |
374900 | ZNF568 | PTC06 | Human | Thyroid | PTC | 3.40e-07 | 1.83e-01 | 0.2057 |
374900 | ZNF568 | PTC07 | Human | Thyroid | PTC | 1.77e-04 | 1.51e-01 | 0.2044 |
374900 | ZNF568 | ATC13 | Human | Thyroid | ATC | 1.08e-114 | 2.16e+00 | 0.34 |
374900 | ZNF568 | ATC5 | Human | Thyroid | ATC | 2.93e-110 | 2.27e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000170111 | Liver | HCC | in utero embryonic development | 204/7958 | 367/18723 | 2.44e-07 | 4.30e-06 | 204 |
GO:000189211 | Liver | HCC | embryonic placenta development | 50/7958 | 82/18723 | 5.62e-04 | 3.61e-03 | 50 |
GO:000189011 | Liver | HCC | placenta development | 81/7958 | 144/18723 | 5.91e-04 | 3.75e-03 | 81 |
GO:00606694 | Liver | HCC | embryonic placenta morphogenesis | 19/7958 | 26/18723 | 1.57e-03 | 8.23e-03 | 19 |
GO:006145811 | Liver | HCC | reproductive system development | 205/7958 | 427/18723 | 1.16e-02 | 4.27e-02 | 205 |
GO:0001701111 | Thyroid | PTC | in utero embryonic development | 175/5968 | 367/18723 | 1.40e-10 | 4.73e-09 | 175 |
GO:000189224 | Thyroid | PTC | embryonic placenta development | 44/5968 | 82/18723 | 3.51e-05 | 3.30e-04 | 44 |
GO:0061458112 | Thyroid | PTC | reproductive system development | 173/5968 | 427/18723 | 8.70e-05 | 7.23e-04 | 173 |
GO:0048608111 | Thyroid | PTC | reproductive structure development | 170/5968 | 424/18723 | 1.86e-04 | 1.41e-03 | 170 |
GO:0001890112 | Thyroid | PTC | placenta development | 66/5968 | 144/18723 | 3.06e-04 | 2.14e-03 | 66 |
GO:006066917 | Thyroid | PTC | embryonic placenta morphogenesis | 16/5968 | 26/18723 | 1.75e-03 | 9.51e-03 | 16 |
GO:000170126 | Thyroid | ATC | in utero embryonic development | 183/6293 | 367/18723 | 6.62e-11 | 2.11e-09 | 183 |
GO:006145827 | Thyroid | ATC | reproductive system development | 193/6293 | 427/18723 | 3.32e-07 | 4.92e-06 | 193 |
GO:004860825 | Thyroid | ATC | reproductive structure development | 190/6293 | 424/18723 | 8.40e-07 | 1.11e-05 | 190 |
GO:000189026 | Thyroid | ATC | placenta development | 70/6293 | 144/18723 | 1.33e-04 | 9.33e-04 | 70 |
GO:0001892111 | Thyroid | ATC | embryonic placenta development | 42/6293 | 82/18723 | 7.34e-04 | 4.11e-03 | 42 |
GO:00485688 | Thyroid | ATC | embryonic organ development | 172/6293 | 427/18723 | 2.08e-03 | 9.84e-03 | 172 |
GO:006066918 | Thyroid | ATC | embryonic placenta morphogenesis | 15/6293 | 26/18723 | 9.95e-03 | 3.63e-02 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF568 | SNV | Missense_Mutation | novel | c.1583N>C | p.Val528Ala | p.V528A | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | |
ZNF568 | deletion | Frame_Shift_Del | novel | c.936_946delNNNNNNNNNNN | p.Lys313SerfsTer7 | p.K313Sfs*7 | Q3ZCX4 | protein_coding | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | ||
ZNF568 | SNV | Missense_Mutation | novel | c.1148N>C | p.Ser383Thr | p.S383T | Q3ZCX4 | protein_coding | tolerated(0.54) | possibly_damaging(0.88) | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF568 | insertion | Frame_Shift_Ins | novel | c.1146_1147insTTTGATTTCTG | p.Ser383PhefsTer4 | p.S383Ffs*4 | Q3ZCX4 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
ZNF568 | insertion | Frame_Shift_Ins | novel | c.1920_1921insGAAGG | p.His641GlufsTer8 | p.H641Efs*8 | Q3ZCX4 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
ZNF568 | insertion | In_Frame_Ins | novel | c.1921_1922insTTT | p.His641delinsLeuTyr | p.H641delinsLY | Q3ZCX4 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
374900 | ZNF568 | NA | opioids |
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