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Gene: USP32 |
Gene summary for USP32 |
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Gene information | Species | Human | Gene symbol | USP32 | Gene ID | 84669 |
Gene name | ubiquitin specific peptidase 32 | |
Gene Alias | NY-REN-60 | |
Cytomap | 17q23.1-q23.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8NFA0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84669 | USP32 | CCI_1 | Human | Cervix | CC | 7.75e-06 | 7.71e-01 | 0.528 |
84669 | USP32 | CCI_2 | Human | Cervix | CC | 2.53e-07 | 9.00e-01 | 0.5249 |
84669 | USP32 | CCI_3 | Human | Cervix | CC | 4.92e-11 | 6.58e-01 | 0.516 |
84669 | USP32 | CCII_1 | Human | Cervix | CC | 3.73e-03 | 3.38e-01 | 0.3249 |
84669 | USP32 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.24e-07 | -4.41e-01 | 0.0155 |
84669 | USP32 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.25e-04 | -3.74e-01 | 0.096 |
84669 | USP32 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.66e-06 | -3.21e-01 | 0.0674 |
84669 | USP32 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.14e-02 | -1.92e-01 | 0.3859 |
84669 | USP32 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.08e-09 | -4.04e-01 | 0.3005 |
84669 | USP32 | A002-C-010 | Human | Colorectum | FAP | 5.99e-04 | -1.83e-01 | 0.242 |
84669 | USP32 | A001-C-207 | Human | Colorectum | FAP | 4.07e-03 | -2.58e-01 | 0.1278 |
84669 | USP32 | A015-C-203 | Human | Colorectum | FAP | 4.30e-25 | -3.67e-01 | -0.1294 |
84669 | USP32 | A015-C-204 | Human | Colorectum | FAP | 4.33e-03 | -2.18e-01 | -0.0228 |
84669 | USP32 | A014-C-040 | Human | Colorectum | FAP | 1.10e-03 | -2.29e-01 | -0.1184 |
84669 | USP32 | A002-C-201 | Human | Colorectum | FAP | 2.42e-13 | -3.69e-01 | 0.0324 |
84669 | USP32 | A002-C-203 | Human | Colorectum | FAP | 6.01e-05 | -2.04e-01 | 0.2786 |
84669 | USP32 | A001-C-119 | Human | Colorectum | FAP | 1.18e-04 | -2.44e-01 | -0.1557 |
84669 | USP32 | A001-C-108 | Human | Colorectum | FAP | 8.27e-12 | -2.35e-01 | -0.0272 |
84669 | USP32 | A002-C-205 | Human | Colorectum | FAP | 4.04e-19 | -3.87e-01 | -0.1236 |
84669 | USP32 | A001-C-104 | Human | Colorectum | FAP | 8.94e-04 | -2.26e-01 | 0.0184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007064612 | Esophagus | ESCC | protein modification by small protein removal | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:00165793 | Esophagus | ESCC | protein deubiquitination | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
GO:0070646 | Liver | NAFLD | protein modification by small protein removal | 29/1882 | 157/18723 | 9.11e-04 | 1.09e-02 | 29 |
GO:0016579 | Liver | NAFLD | protein deubiquitination | 26/1882 | 139/18723 | 1.35e-03 | 1.52e-02 | 26 |
GO:00706461 | Liver | HCC | protein modification by small protein removal | 91/7958 | 157/18723 | 6.50e-05 | 5.92e-04 | 91 |
GO:00165791 | Liver | HCC | protein deubiquitination | 78/7958 | 139/18723 | 8.13e-04 | 4.87e-03 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP32 | SNV | Missense_Mutation | c.747N>G | p.Asp249Glu | p.D249E | Q8NFA0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
USP32 | SNV | Missense_Mutation | novel | c.2749N>G | p.Ser917Gly | p.S917G | Q8NFA0 | protein_coding | deleterious(0.02) | benign(0.18) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
USP32 | SNV | Missense_Mutation | c.3669G>T | p.Glu1223Asp | p.E1223D | Q8NFA0 | protein_coding | deleterious(0.04) | benign(0.326) | TCGA-F1-6177-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
USP32 | SNV | Missense_Mutation | novel | c.2242N>G | p.Ser748Gly | p.S748G | Q8NFA0 | protein_coding | tolerated(0.25) | benign(0.018) | TCGA-HU-A4GH-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
USP32 | SNV | Missense_Mutation | c.1720T>C | p.Tyr574His | p.Y574H | Q8NFA0 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
USP32 | SNV | Missense_Mutation | rs145667783 | c.3586N>A | p.Ala1196Thr | p.A1196T | Q8NFA0 | protein_coding | deleterious(0.03) | possibly_damaging(0.757) | TCGA-VQ-A8PO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
USP32 | deletion | Frame_Shift_Del | novel | c.1277delN | p.Leu426Ter | p.L426* | Q8NFA0 | protein_coding | TCGA-B7-A5TJ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
USP32 | SNV | Missense_Mutation | novel | c.2193N>T | p.Lys731Asn | p.K731N | Q8NFA0 | protein_coding | deleterious(0.01) | possibly_damaging(0.634) | TCGA-DJ-A2QB-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP32 | SNV | Missense_Mutation | novel | c.1688C>A | p.Pro563Gln | p.P563Q | Q8NFA0 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-E8-A2EA-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP32 | SNV | Missense_Mutation | novel | c.3002N>C | p.Val1001Ala | p.V1001A | Q8NFA0 | protein_coding | tolerated(0.57) | benign(0) | TCGA-ET-A3BX-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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