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Gene: STXBP5L |
Gene summary for STXBP5L |
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Gene information | Species | Human | Gene symbol | STXBP5L | Gene ID | 9515 |
Gene name | syntaxin binding protein 5L | |
Gene Alias | LLGL4 | |
Cytomap | 3q13.33 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B4DKF6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9515 | STXBP5L | CCI_1 | Human | Cervix | CC | 2.81e-21 | 1.75e+00 | 0.528 |
9515 | STXBP5L | CCI_3 | Human | Cervix | CC | 2.30e-55 | 2.23e+00 | 0.516 |
9515 | STXBP5L | HTA12-15-2 | Human | Pancreas | PDAC | 9.49e-17 | 1.04e+00 | 0.2315 |
9515 | STXBP5L | HTA12-16-2 | Human | Pancreas | PDAC | 1.71e-02 | 9.14e-01 | 0.0535 |
9515 | STXBP5L | HTA12-23-1 | Human | Pancreas | PDAC | 7.33e-25 | 1.54e+00 | 0.3405 |
9515 | STXBP5L | HTA12-25-1 | Human | Pancreas | PDAC | 9.43e-22 | 1.35e+00 | 0.313 |
9515 | STXBP5L | HTA12-26-1 | Human | Pancreas | PDAC | 7.79e-45 | 1.63e+00 | 0.3728 |
9515 | STXBP5L | HTA12-29-1 | Human | Pancreas | PDAC | 1.48e-110 | 1.73e+00 | 0.3722 |
9515 | STXBP5L | HTA12-30-1 | Human | Pancreas | PDAC | 5.66e-08 | 1.48e+00 | 0.3671 |
9515 | STXBP5L | HTA12-32-1 | Human | Pancreas | PDAC | 1.71e-15 | 1.77e+00 | 0.3624 |
9515 | STXBP5L | HTA12-9-1 | Human | Pancreas | PDAC | 1.32e-03 | 3.60e-01 | 0.1532 |
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Tissue | Expression Dynamics | Abbreviation |
Cervix | ![]() | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
N_HPV: HPV-infected normal cervix |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00171574 | Cervix | CC | regulation of exocytosis | 39/2311 | 202/18723 | 2.90e-03 | 1.93e-02 | 39 |
GO:00068873 | Cervix | CC | exocytosis | 59/2311 | 352/18723 | 8.74e-03 | 4.48e-02 | 59 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STXBP5L | SNV | Missense_Mutation | c.2623N>G | p.Gln875Glu | p.Q875E | Q9Y2K9 | protein_coding | tolerated(0.48) | benign(0.003) | TCGA-77-7141-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
STXBP5L | SNV | Missense_Mutation | rs772460530 | c.2788A>G | p.Arg930Gly | p.R930G | Q9Y2K9 | protein_coding | tolerated(0.11) | benign(0.04) | TCGA-85-6560-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
STXBP5L | SNV | Missense_Mutation | c.1382N>A | p.Pro461Gln | p.P461Q | Q9Y2K9 | protein_coding | tolerated(0.07) | probably_damaging(0.93) | TCGA-85-7697-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
STXBP5L | SNV | Missense_Mutation | c.1534G>A | p.Glu512Lys | p.E512K | Q9Y2K9 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
STXBP5L | SNV | Missense_Mutation | novel | c.3197N>A | p.Gly1066Glu | p.G1066E | Q9Y2K9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-90-A4EE-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
STXBP5L | SNV | Missense_Mutation | c.344T>C | p.Leu115Pro | p.L115P | Q9Y2K9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
STXBP5L | SNV | Missense_Mutation | novel | c.1567N>G | p.Cys523Gly | p.C523G | Q9Y2K9 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-NC-A5HD-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
STXBP5L | SNV | Missense_Mutation | c.262N>T | p.Gly88Trp | p.G88W | Q9Y2K9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-O2-A52V-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
STXBP5L | deletion | Frame_Shift_Del | c.3341delN | p.Gln1114HisfsTer9 | p.Q1114Hfs*9 | Q9Y2K9 | protein_coding | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
STXBP5L | insertion | Frame_Shift_Ins | novel | c.2073dupA | p.Pro692ThrfsTer22 | p.P692Tfs*22 | Q9Y2K9 | protein_coding | TCGA-NC-A5HT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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