GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004586222 | Liver | HCC | positive regulation of proteolysis | 232/7958 | 372/18723 | 5.66e-15 | 3.98e-13 | 232 |
GO:004328112 | Liver | HCC | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 125/7958 | 209/18723 | 3.12e-07 | 5.42e-06 | 125 |
GO:200011612 | Liver | HCC | regulation of cysteine-type endopeptidase activity | 137/7958 | 235/18723 | 6.91e-07 | 1.08e-05 | 137 |
GO:005254722 | Liver | HCC | regulation of peptidase activity | 247/7958 | 461/18723 | 8.28e-07 | 1.27e-05 | 247 |
GO:005254822 | Liver | HCC | regulation of endopeptidase activity | 230/7958 | 432/18723 | 3.58e-06 | 4.68e-05 | 230 |
GO:001095212 | Liver | HCC | positive regulation of peptidase activity | 110/7958 | 197/18723 | 1.04e-04 | 8.98e-04 | 110 |
GO:00705551 | Liver | HCC | response to interleukin-1 | 80/7958 | 143/18723 | 7.95e-04 | 4.77e-03 | 80 |
GO:003461211 | Liver | HCC | response to tumor necrosis factor | 132/7958 | 253/18723 | 1.14e-03 | 6.48e-03 | 132 |
GO:001095012 | Liver | HCC | positive regulation of endopeptidase activity | 96/7958 | 179/18723 | 1.68e-03 | 8.79e-03 | 96 |
GO:004328012 | Liver | HCC | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 70/7958 | 129/18723 | 4.58e-03 | 1.97e-02 | 70 |
GO:200105612 | Liver | HCC | positive regulation of cysteine-type endopeptidase activity | 79/7958 | 148/18723 | 4.82e-03 | 2.03e-02 | 79 |
GO:00713471 | Liver | HCC | cellular response to interleukin-1 | 61/7958 | 113/18723 | 8.98e-03 | 3.46e-02 | 61 |
GO:007135611 | Liver | HCC | cellular response to tumor necrosis factor | 115/7958 | 229/18723 | 1.08e-02 | 3.99e-02 | 115 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ST18 | SNV | Missense_Mutation | | c.109N>T | p.Ala37Ser | p.A37S | O60284 | protein_coding | tolerated(0.07) | benign(0.015) | TCGA-46-6026-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD |
ST18 | SNV | Missense_Mutation | | c.1454C>A | p.Ser485Tyr | p.S485Y | O60284 | protein_coding | deleterious(0) | benign(0.323) | TCGA-51-4081-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
ST18 | SNV | Missense_Mutation | novel | c.82N>G | p.Leu28Val | p.L28V | O60284 | protein_coding | tolerated(0.25) | benign(0.333) | TCGA-56-7223-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ST18 | SNV | Missense_Mutation | novel | c.189C>A | p.His63Gln | p.H63Q | O60284 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-56-A49D-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ST18 | SNV | Missense_Mutation | novel | c.1702N>A | p.Glu568Lys | p.E568K | O60284 | protein_coding | tolerated(0.08) | probably_damaging(0.969) | TCGA-56-A5DR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ST18 | SNV | Missense_Mutation | novel | c.1030G>T | p.Val344Phe | p.V344F | O60284 | protein_coding | tolerated(0.25) | possibly_damaging(0.798) | TCGA-56-A62T-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
ST18 | SNV | Missense_Mutation | | c.849C>A | p.Ser283Arg | p.S283R | O60284 | protein_coding | tolerated(0.31) | benign(0) | TCGA-56-A62T-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR |
ST18 | SNV | Missense_Mutation | novel | c.673G>T | p.Asp225Tyr | p.D225Y | O60284 | protein_coding | tolerated(0.05) | benign(0) | TCGA-60-2703-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ST18 | SNV | Missense_Mutation | novel | c.2782C>A | p.His928Asn | p.H928N | O60284 | protein_coding | tolerated(0.09) | benign(0.046) | TCGA-60-2714-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
ST18 | SNV | Missense_Mutation | novel | c.688C>A | p.Leu230Ile | p.L230I | O60284 | protein_coding | tolerated(0.56) | benign(0) | TCGA-60-2714-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |