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Gene: SMC1A |
Gene summary for SMC1A |
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Gene information | Species | Human | Gene symbol | SMC1A | Gene ID | 8243 |
Gene name | structural maintenance of chromosomes 1A | |
Gene Alias | CDLS2 | |
Cytomap | Xp11.22 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | G8JLG1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8243 | SMC1A | HTA11_347_2000001011 | Human | Colorectum | AD | 8.17e-09 | 3.95e-01 | -0.1954 |
8243 | SMC1A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.36e-07 | 4.79e-01 | 0.281 |
8243 | SMC1A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.89e-05 | 3.58e-01 | 0.3859 |
8243 | SMC1A | A002-C-205 | Human | Colorectum | FAP | 4.14e-04 | 2.79e-01 | -0.1236 |
8243 | SMC1A | LZE2T | Human | Esophagus | ESCC | 1.53e-13 | 1.14e+00 | 0.082 |
8243 | SMC1A | LZE4T | Human | Esophagus | ESCC | 3.29e-05 | 2.30e-01 | 0.0811 |
8243 | SMC1A | LZE5T | Human | Esophagus | ESCC | 2.36e-03 | 6.58e-01 | 0.0514 |
8243 | SMC1A | LZE7T | Human | Esophagus | ESCC | 4.96e-11 | 7.67e-01 | 0.0667 |
8243 | SMC1A | LZE8T | Human | Esophagus | ESCC | 9.48e-07 | 3.55e-01 | 0.067 |
8243 | SMC1A | LZE20T | Human | Esophagus | ESCC | 3.21e-08 | 2.63e-01 | 0.0662 |
8243 | SMC1A | LZE22T | Human | Esophagus | ESCC | 2.41e-03 | 6.17e-01 | 0.068 |
8243 | SMC1A | LZE24T | Human | Esophagus | ESCC | 8.62e-30 | 7.72e-01 | 0.0596 |
8243 | SMC1A | LZE21T | Human | Esophagus | ESCC | 2.73e-02 | 4.69e-01 | 0.0655 |
8243 | SMC1A | LZE6T | Human | Esophagus | ESCC | 2.30e-04 | 2.90e-01 | 0.0845 |
8243 | SMC1A | P1T-E | Human | Esophagus | ESCC | 4.99e-07 | 4.01e-01 | 0.0875 |
8243 | SMC1A | P2T-E | Human | Esophagus | ESCC | 2.76e-101 | 1.97e+00 | 0.1177 |
8243 | SMC1A | P4T-E | Human | Esophagus | ESCC | 9.57e-24 | 6.26e-01 | 0.1323 |
8243 | SMC1A | P5T-E | Human | Esophagus | ESCC | 1.53e-21 | 5.19e-01 | 0.1327 |
8243 | SMC1A | P8T-E | Human | Esophagus | ESCC | 2.28e-36 | 8.10e-01 | 0.0889 |
8243 | SMC1A | P9T-E | Human | Esophagus | ESCC | 1.51e-18 | 4.68e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007051 | Colorectum | AD | spindle organization | 58/3918 | 184/18723 | 4.71e-04 | 5.20e-03 | 58 |
GO:1902850 | Colorectum | AD | microtubule cytoskeleton organization involved in mitosis | 48/3918 | 147/18723 | 5.87e-04 | 6.21e-03 | 48 |
GO:0090307 | Colorectum | AD | mitotic spindle assembly | 25/3918 | 65/18723 | 9.12e-04 | 8.71e-03 | 25 |
GO:0007052 | Colorectum | AD | mitotic spindle organization | 40/3918 | 120/18723 | 1.03e-03 | 9.61e-03 | 40 |
GO:0007064 | Colorectum | AD | mitotic sister chromatid cohesion | 13/3918 | 28/18723 | 2.22e-03 | 1.75e-02 | 13 |
GO:0007062 | Colorectum | AD | sister chromatid cohesion | 23/3918 | 62/18723 | 2.51e-03 | 1.92e-02 | 23 |
GO:0051225 | Colorectum | AD | spindle assembly | 37/3918 | 117/18723 | 4.32e-03 | 2.96e-02 | 37 |
GO:0140014 | Colorectum | AD | mitotic nuclear division | 78/3918 | 287/18723 | 6.48e-03 | 4.05e-02 | 78 |
GO:00070511 | Colorectum | MSS | spindle organization | 53/3467 | 184/18723 | 4.23e-04 | 5.19e-03 | 53 |
GO:19028501 | Colorectum | MSS | microtubule cytoskeleton organization involved in mitosis | 44/3467 | 147/18723 | 5.17e-04 | 5.98e-03 | 44 |
GO:00070521 | Colorectum | MSS | mitotic spindle organization | 36/3467 | 120/18723 | 1.52e-03 | 1.39e-02 | 36 |
GO:00903071 | Colorectum | MSS | mitotic spindle assembly | 22/3467 | 65/18723 | 2.33e-03 | 1.90e-02 | 22 |
GO:00070621 | Colorectum | MSS | sister chromatid cohesion | 20/3467 | 62/18723 | 6.63e-03 | 4.38e-02 | 20 |
GO:00512251 | Colorectum | MSS | spindle assembly | 33/3467 | 117/18723 | 6.68e-03 | 4.38e-02 | 33 |
GO:01400141 | Colorectum | MSS | mitotic nuclear division | 70/3467 | 287/18723 | 7.48e-03 | 4.72e-02 | 70 |
GO:00070641 | Colorectum | MSS | mitotic sister chromatid cohesion | 11/3467 | 28/18723 | 8.30e-03 | 5.00e-02 | 11 |
GO:0019827 | Colorectum | FAP | stem cell population maintenance | 33/2622 | 131/18723 | 4.61e-04 | 5.39e-03 | 33 |
GO:0098727 | Colorectum | FAP | maintenance of cell number | 33/2622 | 134/18723 | 7.09e-04 | 7.64e-03 | 33 |
GO:00070642 | Colorectum | FAP | mitotic sister chromatid cohesion | 11/2622 | 28/18723 | 8.55e-04 | 8.79e-03 | 11 |
GO:00070512 | Colorectum | FAP | spindle organization | 41/2622 | 184/18723 | 1.50e-03 | 1.34e-02 | 41 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04110 | Colorectum | FAP | Cell cycle | 37/1404 | 157/8465 | 1.44e-02 | 4.77e-02 | 2.90e-02 | 37 |
hsa041101 | Colorectum | FAP | Cell cycle | 37/1404 | 157/8465 | 1.44e-02 | 4.77e-02 | 2.90e-02 | 37 |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa041146 | Esophagus | ESCC | Oocyte meiosis | 77/4205 | 131/8465 | 2.19e-02 | 4.80e-02 | 2.46e-02 | 77 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa0411411 | Esophagus | ESCC | Oocyte meiosis | 77/4205 | 131/8465 | 2.19e-02 | 4.80e-02 | 2.46e-02 | 77 |
hsa041102 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa041103 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa04114 | Oral cavity | OSCC | Oocyte meiosis | 74/3704 | 131/8465 | 2.13e-03 | 5.75e-03 | 2.92e-03 | 74 |
hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa041141 | Oral cavity | OSCC | Oocyte meiosis | 74/3704 | 131/8465 | 2.13e-03 | 5.75e-03 | 2.92e-03 | 74 |
hsa0411022 | Oral cavity | LP | Cell cycle | 70/2418 | 157/8465 | 1.17e-05 | 8.27e-05 | 5.33e-05 | 70 |
hsa0411032 | Oral cavity | LP | Cell cycle | 70/2418 | 157/8465 | 1.17e-05 | 8.27e-05 | 5.33e-05 | 70 |
hsa0411041 | Oral cavity | EOLP | Cell cycle | 42/1218 | 157/8465 | 3.20e-05 | 1.61e-04 | 9.52e-05 | 42 |
hsa041142 | Oral cavity | EOLP | Oocyte meiosis | 33/1218 | 131/8465 | 7.09e-04 | 2.69e-03 | 1.59e-03 | 33 |
hsa0411051 | Oral cavity | EOLP | Cell cycle | 42/1218 | 157/8465 | 3.20e-05 | 1.61e-04 | 9.52e-05 | 42 |
hsa041143 | Oral cavity | EOLP | Oocyte meiosis | 33/1218 | 131/8465 | 7.09e-04 | 2.69e-03 | 1.59e-03 | 33 |
hsa0411061 | Oral cavity | NEOLP | Cell cycle | 37/1112 | 157/8465 | 2.29e-04 | 1.58e-03 | 9.95e-04 | 37 |
hsa041144 | Oral cavity | NEOLP | Oocyte meiosis | 31/1112 | 131/8465 | 6.64e-04 | 3.52e-03 | 2.21e-03 | 31 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SMC1A | SNV | Missense_Mutation | novel | c.2879N>G | p.Glu960Gly | p.E960G | Q14683 | protein_coding | tolerated(0.16) | benign(0.001) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SMC1A | SNV | Missense_Mutation | c.2106G>T | p.Gln702His | p.Q702H | Q14683 | protein_coding | tolerated(0.09) | possibly_damaging(0.838) | TCGA-98-A53B-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SMC1A | SNV | Missense_Mutation | novel | c.2940N>C | p.Glu980Asp | p.E980D | Q14683 | protein_coding | tolerated(0.1) | possibly_damaging(0.534) | TCGA-CN-6023-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | erbitux | SD |
SMC1A | SNV | Missense_Mutation | novel | c.897C>G | p.Ile299Met | p.I299M | Q14683 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-CQ-5334-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SMC1A | SNV | Missense_Mutation | novel | c.1796N>A | p.Arg599His | p.R599H | Q14683 | protein_coding | tolerated(0.16) | benign(0.037) | TCGA-CV-7429-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
SMC1A | SNV | Missense_Mutation | c.1525C>G | p.Arg509Gly | p.R509G | Q14683 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-VP-A87E-01 | Prostate | prostate adenocarcinoma | Male | <65 | 6 | Unknown | Unknown | SD | |
SMC1A | SNV | Missense_Mutation | c.1211N>G | p.Gln404Arg | p.Q404R | Q14683 | protein_coding | deleterious(0.04) | possibly_damaging(0.679) | TCGA-BR-4363-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SMC1A | SNV | Missense_Mutation | c.1486C>T | p.Arg496Cys | p.R496C | Q14683 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SMC1A | SNV | Missense_Mutation | c.1277N>A | p.Arg426Gln | p.R426Q | Q14683 | protein_coding | tolerated(0.15) | benign(0.024) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SMC1A | SNV | Missense_Mutation | c.578C>T | p.Ala193Val | p.A193V | Q14683 | protein_coding | tolerated(0.09) | possibly_damaging(0.733) | TCGA-BR-A4IY-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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