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Gene: SLITRK4 |
Gene summary for SLITRK4 |
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Gene information | Species | Human | Gene symbol | SLITRK4 | Gene ID | 139065 |
Gene name | SLIT and NTRK like family member 4 | |
Gene Alias | SLITRK4 | |
Cytomap | Xq27.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q8IW52 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
139065 | SLITRK4 | PTC03 | Human | Thyroid | PTC | 1.79e-02 | 2.26e-01 | 0.1784 |
139065 | SLITRK4 | PTC05 | Human | Thyroid | PTC | 2.31e-02 | 1.34e-01 | 0.2065 |
139065 | SLITRK4 | ATC11 | Human | Thyroid | ATC | 1.60e-07 | 6.27e-01 | 0.3386 |
139065 | SLITRK4 | ATC3 | Human | Thyroid | ATC | 1.86e-15 | 8.59e-01 | 0.338 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:006156419 | Thyroid | PTC | axon development | 199/5968 | 467/18723 | 5.27e-07 | 8.53e-06 | 199 |
GO:0034329111 | Thyroid | PTC | cell junction assembly | 180/5968 | 420/18723 | 1.17e-06 | 1.69e-05 | 180 |
GO:000740918 | Thyroid | PTC | axonogenesis | 178/5968 | 418/18723 | 2.17e-06 | 2.91e-05 | 178 |
GO:005196214 | Thyroid | PTC | positive regulation of nervous system development | 117/5968 | 272/18723 | 6.72e-05 | 5.89e-04 | 117 |
GO:00519608 | Thyroid | PTC | regulation of nervous system development | 177/5968 | 443/18723 | 1.72e-04 | 1.32e-03 | 177 |
GO:190188817 | Thyroid | PTC | regulation of cell junction assembly | 88/5968 | 204/18723 | 4.50e-04 | 2.97e-03 | 88 |
GO:00508089 | Thyroid | PTC | synapse organization | 161/5968 | 426/18723 | 5.11e-03 | 2.36e-02 | 161 |
GO:00508074 | Thyroid | PTC | regulation of synapse organization | 84/5968 | 211/18723 | 8.72e-03 | 3.64e-02 | 84 |
GO:00508032 | Thyroid | PTC | regulation of synapse structure or activity | 86/5968 | 218/18723 | 1.05e-02 | 4.23e-02 | 86 |
GO:006156423 | Thyroid | ATC | axon development | 220/6293 | 467/18723 | 6.85e-10 | 1.80e-08 | 220 |
GO:000740919 | Thyroid | ATC | axonogenesis | 197/6293 | 418/18723 | 5.09e-09 | 1.13e-07 | 197 |
GO:003432924 | Thyroid | ATC | cell junction assembly | 187/6293 | 420/18723 | 1.71e-06 | 2.08e-05 | 187 |
GO:005196014 | Thyroid | ATC | regulation of nervous system development | 195/6293 | 443/18723 | 2.62e-06 | 3.06e-05 | 195 |
GO:005196221 | Thyroid | ATC | positive regulation of nervous system development | 126/6293 | 272/18723 | 8.17e-06 | 8.27e-05 | 126 |
GO:190188818 | Thyroid | ATC | regulation of cell junction assembly | 94/6293 | 204/18723 | 1.38e-04 | 9.65e-04 | 94 |
GO:005080712 | Thyroid | ATC | regulation of synapse organization | 87/6293 | 211/18723 | 1.20e-02 | 4.27e-02 | 87 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLITRK4 | SNV | Missense_Mutation | c.1634N>T | p.Trp545Leu | p.W545L | Q8IW52 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-8120-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLITRK4 | SNV | Missense_Mutation | novel | c.463N>A | p.His155Asn | p.H155N | Q8IW52 | protein_coding | tolerated(0.42) | benign(0.241) | TCGA-44-A479-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SLITRK4 | SNV | Missense_Mutation | novel | c.859N>A | p.Pro287Thr | p.P287T | Q8IW52 | protein_coding | tolerated(0.08) | benign(0.065) | TCGA-49-AAR4-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxol | PD |
SLITRK4 | SNV | Missense_Mutation | c.654N>G | p.Ser218Arg | p.S218R | Q8IW52 | protein_coding | deleterious(0) | benign(0.258) | TCGA-49-AAR9-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SLITRK4 | SNV | Missense_Mutation | c.2361N>A | p.Asp787Glu | p.D787E | Q8IW52 | protein_coding | tolerated(0.52) | benign(0.007) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
SLITRK4 | SNV | Missense_Mutation | c.107A>T | p.Glu36Val | p.E36V | Q8IW52 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD | |
SLITRK4 | SNV | Missense_Mutation | c.2386G>T | p.Gly796Cys | p.G796C | Q8IW52 | protein_coding | tolerated(0.2) | benign(0.053) | TCGA-50-5933-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR | |
SLITRK4 | SNV | Missense_Mutation | novel | c.2261N>G | p.Asp754Gly | p.D754G | Q8IW52 | protein_coding | deleterious(0.03) | benign(0.01) | TCGA-50-5935-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLITRK4 | SNV | Missense_Mutation | c.380T>C | p.Phe127Ser | p.F127S | Q8IW52 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-50-5941-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unspecific | Cisplatin | Complete Response | |
SLITRK4 | SNV | Missense_Mutation | c.320G>A | p.Ser107Asn | p.S107N | Q8IW52 | protein_coding | tolerated(0.05) | benign(0.119) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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