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Gene: SLC8A1 |
Gene summary for SLC8A1 |
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Gene information | Species | Human | Gene symbol | SLC8A1 | Gene ID | 6546 |
Gene name | solute carrier family 8 member A1 | |
Gene Alias | NCX1 | |
Cytomap | 2p22.1 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | P32418 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6546 | SLC8A1 | HTA12-15-2 | Human | Pancreas | PDAC | 2.08e-13 | 8.43e-01 | 0.2315 |
6546 | SLC8A1 | HTA12-23-1 | Human | Pancreas | PDAC | 1.74e-14 | 1.13e+00 | 0.3405 |
6546 | SLC8A1 | HTA12-25-1 | Human | Pancreas | PDAC | 3.64e-05 | 5.43e-01 | 0.313 |
6546 | SLC8A1 | HTA12-26-1 | Human | Pancreas | PDAC | 2.45e-25 | 1.19e+00 | 0.3728 |
6546 | SLC8A1 | HTA12-29-1 | Human | Pancreas | PDAC | 1.30e-63 | 1.36e+00 | 0.3722 |
6546 | SLC8A1 | HTA12-30-1 | Human | Pancreas | PDAC | 3.91e-06 | 1.25e+00 | 0.3671 |
6546 | SLC8A1 | HTA12-32-1 | Human | Pancreas | PDAC | 1.46e-03 | 7.79e-01 | 0.3624 |
6546 | SLC8A1 | HTA12-9-2 | Human | Pancreas | PDAC | 2.67e-04 | 3.31e-01 | 0.0835 |
6546 | SLC8A1 | ATC11 | Human | Thyroid | ATC | 5.35e-04 | 4.03e-01 | 0.3386 |
6546 | SLC8A1 | ATC12 | Human | Thyroid | ATC | 2.74e-06 | 1.66e-01 | 0.34 |
6546 | SLC8A1 | ATC13 | Human | Thyroid | ATC | 2.71e-09 | 2.08e-01 | 0.34 |
6546 | SLC8A1 | ATC2 | Human | Thyroid | ATC | 2.49e-06 | 5.69e-01 | 0.34 |
6546 | SLC8A1 | ATC3 | Human | Thyroid | ATC | 4.97e-10 | 5.41e-01 | 0.338 |
6546 | SLC8A1 | ATC4 | Human | Thyroid | ATC | 1.33e-07 | 2.03e-01 | 0.34 |
6546 | SLC8A1 | ATC5 | Human | Thyroid | ATC | 5.88e-09 | 2.25e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697934 | Thyroid | ATC | response to oxidative stress | 246/6293 | 446/18723 | 2.98e-21 | 6.09e-19 | 246 |
GO:007048228 | Thyroid | ATC | response to oxygen levels | 193/6293 | 347/18723 | 1.83e-17 | 1.93e-15 | 193 |
GO:001056334 | Thyroid | ATC | negative regulation of phosphorus metabolic process | 234/6293 | 442/18723 | 2.30e-17 | 2.31e-15 | 234 |
GO:004593634 | Thyroid | ATC | negative regulation of phosphate metabolic process | 233/6293 | 441/18723 | 3.68e-17 | 3.47e-15 | 233 |
GO:000193333 | Thyroid | ATC | negative regulation of protein phosphorylation | 186/6293 | 342/18723 | 1.43e-15 | 1.08e-13 | 186 |
GO:003629328 | Thyroid | ATC | response to decreased oxygen levels | 177/6293 | 322/18723 | 1.81e-15 | 1.32e-13 | 177 |
GO:004232634 | Thyroid | ATC | negative regulation of phosphorylation | 203/6293 | 385/18723 | 5.30e-15 | 3.53e-13 | 203 |
GO:000166628 | Thyroid | ATC | response to hypoxia | 169/6293 | 307/18723 | 6.58e-15 | 4.12e-13 | 169 |
GO:000030234 | Thyroid | ATC | response to reactive oxygen species | 128/6293 | 222/18723 | 1.38e-13 | 7.00e-12 | 128 |
GO:004254233 | Thyroid | ATC | response to hydrogen peroxide | 92/6293 | 146/18723 | 3.12e-13 | 1.46e-11 | 92 |
GO:000150332 | Thyroid | ATC | ossification | 206/6293 | 408/18723 | 9.23e-13 | 3.95e-11 | 206 |
GO:005134834 | Thyroid | ATC | negative regulation of transferase activity | 144/6293 | 268/18723 | 7.63e-12 | 2.91e-10 | 144 |
GO:000166731 | Thyroid | ATC | ameboidal-type cell migration | 228/6293 | 475/18723 | 3.72e-11 | 1.22e-09 | 228 |
GO:007190025 | Thyroid | ATC | regulation of protein serine/threonine kinase activity | 176/6293 | 359/18723 | 8.35e-10 | 2.17e-08 | 176 |
GO:000646925 | Thyroid | ATC | negative regulation of protein kinase activity | 114/6293 | 212/18723 | 1.06e-09 | 2.69e-08 | 114 |
GO:003367325 | Thyroid | ATC | negative regulation of kinase activity | 122/6293 | 237/18723 | 9.19e-09 | 1.94e-07 | 122 |
GO:007145325 | Thyroid | ATC | cellular response to oxygen levels | 94/6293 | 177/18723 | 6.62e-08 | 1.17e-06 | 94 |
GO:0031667210 | Thyroid | ATC | response to nutrient levels | 212/6293 | 474/18723 | 2.37e-07 | 3.70e-06 | 212 |
GO:003629425 | Thyroid | ATC | cellular response to decreased oxygen levels | 85/6293 | 161/18723 | 3.86e-07 | 5.65e-06 | 85 |
GO:005123532 | Thyroid | ATC | maintenance of location | 152/6293 | 327/18723 | 7.84e-07 | 1.04e-05 | 152 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC8A1 | SNV | Missense_Mutation | c.641N>T | p.Ala214Val | p.A214V | P32418 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-78-7542-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLC8A1 | SNV | Missense_Mutation | novel | c.2204N>A | p.Leu735Gln | p.L735Q | P32418 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SLC8A1 | SNV | Missense_Mutation | novel | c.2737C>A | p.Leu913Ile | p.L913I | P32418 | protein_coding | tolerated(0.38) | benign(0.388) | TCGA-80-5608-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
SLC8A1 | SNV | Missense_Mutation | c.1897G>C | p.Glu633Gln | p.E633Q | P32418 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC8A1 | SNV | Missense_Mutation | rs758440605 | c.916G>T | p.Gly306Cys | p.G306C | P32418 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-91-6829-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLC8A1 | SNV | Missense_Mutation | novel | c.928C>A | p.Leu310Met | p.L310M | P32418 | protein_coding | tolerated(0.28) | benign(0.348) | TCGA-99-7458-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | tarceva | SD |
SLC8A1 | SNV | Missense_Mutation | c.1082N>T | p.Arg361Ile | p.R361I | P32418 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLC8A1 | SNV | Missense_Mutation | c.2542N>G | p.Pro848Ala | p.P848A | P32418 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-MP-A4SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC8A1 | SNV | Missense_Mutation | c.1493T>A | p.Val498Asp | p.V498D | P32418 | protein_coding | deleterious(0.01) | probably_damaging(0.913) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SLC8A1 | SNV | Missense_Mutation | rs760339904 | c.1038N>G | p.Ile346Met | p.I346M | P32418 | protein_coding | tolerated(0.1) | benign(0.031) | TCGA-21-5784-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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